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Table 3 Results of crude and adjusted logistic regression analysis of infertility by thyroid function and TPOAb status

From: The association between subclinical hypothyroidism and TPOAb positivity with infertility in a population-based study: Tehran thyroid study (TTS)

Female

Male

Crude models

 

*OR of infertility (95%CI)

P_value

*OR of infertility (95%CI)

P_value

 FT4 (ng/dl)

0.997 (0.602–1.650)

0.991

0.189 (0.056, 0.637)

* 0.007

 TSH (mU/L)

1.015 (0.976–1.054)

0.458

1.028 (1.001, 1.055)

* 0.042

 TPOAb (IU/ml)

0.999 (0.998–1.000)

0.222

1.00 (0.996, 1.003)

0.833

 TPOAb

Positive

1.0 (0.8,1.35)

0.953

0.7 (0.3,1. 5)

0.392

Negative

(ref)

 

(ref)

 

Age-and-BMI-Adjusted models

 FT4 (ng/dl)

1.003 (0.600–1.676)

0.991

0.280 (0.081, 0,967)

* 0.044

 TSH (mU/L)

1.012 (0.974–1.052)

0.536

1.025 (0.998, 1.052)

0.070

 TPOAb (IU/ml)

0.999 (0. 998–1.000)

0.194

1.00 (0.996, 1.003)

0.874

 TPOAb

Positive

0.97 (0.7,1.35)

0.888

0.7 (0.3,1.6)

0.416

Negative

(ref)

 

(ref)

 

ΨMulti-Adjusted models

 FT4 (ng/dl)

1.007 (0.596–1.702)

0.978

0.265 (0.075, 0.940)

* 0.040

 TSH (mU/L)

1.012 (0.973–1.052)

0.552

1.026 (0.999, 1.053)

0.061

 TPOAb (IU/ml)

0.999 (0.998–1.000)

0.196

1.00 (0. 997, 1.003)

0.915

 TPOAb

Positive

0.983 (0.694–1.393)

0.924

0.778 (0.304,1.992)

0.610

Negative

(ref)

 

(ref)

 
  1. *significant p-value < 0.05
  2. ΨAdjusted by Age, education, BMI, Smoking, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Fasting blood Sugar (FBS)