Table 1 Clinical and Biochemical Characteristics of the Study Population
TOTAL | Normal BMI | Overweight (BMI ≥ 25) | Obese (BMI ≥ 30) | p-value+ |
|---|---|---|---|---|
(n, %) | (2057, 38.4%) | (2152, 40.2%) | (1144, 21.4%) | |
Age (year) | 36 ± 14 | 42 ± 14 | 45 ± 13 | < 0.001 |
TSH (mU/L) | 1.56 (1.68) | 1.59 (1.66) | 1.69 (1.81) | < 0.001 |
FT4 (ng/dL) | 1.25 (0.24) | 1.20 (0.24) | 1.17 (0.24) | < 0.001 |
TPOAb (IU/ml) | 5.43 (7.94) | 5.60 (8.60) | 6.34 (12.11) | < 0.001 |
Waist Circumference | < 0.001 | |||
WC | 77.0 (11.0) | 90 (10) | 101 (9) | |
Abnormal WC ratio | 6.8% | 55.5% | 92.3% | |
Smoking Status | < 0.001 | |||
Ever | 358 (17.4%) | 313 (14.5%) | 121 (10.6%) | |
Never | 1699 (82.6%) | 1839 (85.5%) | 1023 (89.4%) | |
TPOAb positivity | < 0.001 | |||
Yes | 239 (11.6%) 1818 | 299 (13.9%) | 198 (17.3%) | |
NO | (88.4%) | 1853 (86.1%) | 946 (82.7%) | |
Thyroid Status | < 0.001 | |||
Euthyroid | 1787 (86.9%) | 1837 (85.5%) | 963 (84.2%) | |
Subclinical hypothyroidism | 146 (7.1%) | 144 (6.7%) | 87 (7.6%) | |
overt hypothyroidism | 23 (1.1%) | 48 (2.2%) | 46 (4.0%) | |
Total hypothyroidism | 169 (8.2%) | 192 (8.8%) | 133 (11.6%) | |
Subclinical hyperthyroidism | 57 (2.8%) | 85 (3.9%) | 31 (2.7%) | |
overt hyperthyroidism | 44 (2.1%) | 38 (1.8%) | 17 (1.5%) | |
Total hyperthyroidism | 101 (4.9%) | 123 (5.7%) | 48 (4.2%) | |
FEMALE (3079, 57.5%) | (1068, 34.7%) | (1196, 38.8%) | (815, 26.5%) | |
Age (year) | 33 ± 12 | 41 ± 13 | 45 ± 12 | < 0.001 |
TSH (mU/L) | 1.78 (1.99) | 1.87 (2.16) | 1.85 (2.07) | 0.497 |
FT4 (ng/dL) | 1.20 (0.22) | 1.15 (0.23) | 1.14 (0.24) | < 0.001 |
TPOAb (IU/ml) | 5.81 (10.52) | 6.33 (12.64) | 6.86 (17.25) | < 0.001 |
Waist Circumference | < 0.001 | |||
WC | 75 (10) | 87 (11) | 100 (12) | |
Abnormal WC ratio | 3.9% | 39.4% | 89.7% | |
Smoking Status | 0.875 | |||
Ever smoker | 36 (3.4%) | 45 (3.8%) | 30 (3.7%) | |
Never smoker | 1032 (96.6%) | 1151 (96.2%) | 785 (96.3%) | |
TPOAb positivity | 0.004 | |||
Yes | 154 (14.4%) | 209 (17.5%) | 165 (20.2%) | |
NO | 914 (85.6%) | 987 (82.5%) | 650 (79.8%) | |
Thyroid Status | 0.008 | |||
Euthyroid | 882 (82.6%) | 971 (81.2%) | 663 (81.3%) | |
Subclinical hypothyroidism | 110 (10.3%) | 113 (9.4%) | 78 (9.6%) | |
Overt hypothyroidism | 20 (1.9%) | 39 (3.3%) | 41 (5.0%) | |
Total hypothyroidism | 130 (12.2%) | 152 (12.7%) | 120 (14.6%) | |
Subclinical hyperthyroidism | 33 (3.1%) | 51 (4.3%) | 20 (2.5%) | |
Overt hyperthyroidism | 23 (2.2%) | 22 (1.8%) | 13 (1.6%) | |
Total hyperthyroidism | 56 (5.3%) | 73 (6.1%) | 33 (4.1%) | |
MALE (2274, 42.5%) | (989, 43.5%) | (956, 42.0%) | (329, 14.5%) | |
Age (year) | 39 ± 16 | 44 ± 14 | 43 ± 14 | < 0.001 |
TSH (mU/L) | 1.41 (1.29) | 1.38 (1.21) | 1.46 (1.36) | 0.570 |
FT4 (ng/dL) | 1.29 (0.25) | 1.25 (0.23) | 1.24 (0.25) | < 0.001 |
TPOAb (IU/ml) | 5.24 (6.45) | 5.08 (5.67) | 5.08 (7.80) | 0.845 |
Waist Circumference | < 0.001 | |||
WC | 80 (10) | 94 (8) | 104 (9) | |
Abnormal WC ratio | 9.8% | 75.6% | 98.8% | |
Smoking Status | 0.058 | |||
Ever smoker | 322 (32.6%) | 268 (28.0%) | 91 (27.7%) | |
Never smoker | 667 (67.4%) | 688 (72.0%) | 238 (72.3%) | |
TPOAb positivity | 0.686 | |||
Yes | 85 (8.6%) | 90 (9.4%) | 33 (10.0%) | |
NO | 904 (91.4%) | 866 (90.6%) | 296 (90.0%) | |
Thyroid Status | 0.275 | |||
Euthyroid | 905 (91.5%) | 866 (90.6%) | 300 (91.2%) | |
Subclinical hypothyroidism | 36 (3.6%) | 31 (3.2%) | 9 (2.7%) | |
Overt hypothyroidism | 3 (0.3%) | 9 (0.9%) | 5 (1.5%) | |
Total hypothyroidism | 39 (3.9%) | 40 (4.21%) | 14 (4.3%) | |
Subclinical hyperthyroidism | 24 (2.4%) | 34 (3.6%) | 11 (3.3%) | |
Overt hyperthyroidism | 21 (2.1%) | 16 (1.7%) | 4 (1.2%) | |
Total hyperthyroidism | 45 (4.5%) | 50 (5.3%) | 15 (4.6%) | |