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Table 3 Points system and associated risks for central precocious puberty in the training and validation sample

From: Clinical risk score for central precocious puberty among girls with precocious pubertal development: a cross sectional study

CPP risk category

Points total

Estimate of risk (95% CI) a

No. with CPP/ Total No. of patients in training sample (%)

No. with CPP/ Total No. of patients in validation sample (%)

Low risk

0

0.01 (0.01, 0.03)

0/0 (−)

0/1 (0.0)

1

0.01 (0.01, 0.04)

0/1 (0.0)

0/3 (0.0)

2

0.02 (0.01, 0.05)

0/3 (0.0)

0/0 (−)

3

0.03 (0.01, 0.07)

0/4 (0.0)

0/6 (0.0)

4

0.04 (0.02, 0.08)

0/2 (0.0)

0/5 (0.0)

5

0.05 (0.02, 0.10)

1/3 (33.3)

0/1 (0.0)

6

0.07 (0.04, 0.13)

0/6 (0.0)

0/3 (0.0)

7

0.09 (0.05, 0.16)

0/3 (0.0)

0/3 (0.0)

8

0.12 (0.08, 0.20)

1/9 (12.5)

0/6 (0.0)

9

0.16 (0.11, 0.24)

2/9 (22.2)

0/11 (0.0)

Medium risk

10

0.21 (0.15, 0.29)

4/19 (21.1)

3/19 (15.8)

11

0.27 (0.21, 0.35)

5/21 (23.8)

10/19 (52.6)

12

0.34 (0.27, 0.42)

7/28 (25.0)

13/37 (35.1)

13

0.42 (0.35, 0.49)

10/24 (41.7)

7/19 (36.8)

14

0.50 (0.43, 0.57)

16/29 (55.2)

17/35 (48.6)

15

0.58 (0.51, 0.65)

14/25 (56.0)

17/32 (53.1)

16

0.66 (0.58, 0.72)

15/19 (79.0)

14/14 (100.0)

17

0.72 (0.65, 0.79)

9/11 (81.8)

14/17 (82.4)

18

0.78 (0.70, 0.85)

13/15 (86.7)

5/6 (83.3)

19

0.83 (0.76, 0.89)

7/10 (70.0)

12/12 (100.0)

High risk

20

0.87 (0.80, 0.92)

9/10 (90.0)

6/6 (100.0)

21

0.91 (0.84, 0.95)

8/9 (88.9)

7/8 (87.5)

22

0.93 (0.87, 0.96)

3/3 (100.0)

5/6 (83.3)

23

0.95 (0.90, 0.98)

6/8 (75.0)

4/5 (80.0)

24

0.96 (0.92, 0.98)

10/11 (90.9)

6/7 (85.7)

25

0.97 (0.93, 0.99)

5/5 (100.0)

3/3 (100.0)

26

0.98 (0.95, 0.99)

8/8 (100.0)

5/5 (100.0)

27

0.99 (0.96, 0.99)

2/2 (100.0)

4/4 (100.0)

28

0.99 (0.97, 1.00)

4/4 (100.0)

3/3 (100.0)

29

0.99 (0.97, 1.00)

3/3 (100.0)

1/1 (100.0)

30

0.99 (0.98, 1.00)

2/2 (100.0)

1/1 (100.0)

31

1.00 (0.98, 1.00)

6/6 (100.0)

7/7 (100.0)

32

1.00 (0.99, 1.00)

0/0 (−)

0/0 (−)

33

1.00 (0.99, 1.00)

2/2 (100.0)

8/8 (100.0)

  1. a \( \hat{p}=\frac{1}{1+\exp \left(-{\sum}_{i=0}^p{\beta}_i{X}_i\right)} \), \( {\sum}_{i=0}^p{\beta}_i{X}_i \) = − 6.42 + 0.45*0.5 + 1.63*0.1 + 0.66*1 + 0.85*1 + B*(Point total)
  2. We define the constant B for the points system (the number of regression units that will correspond to one point) as the increase in risk of CPP associated with a 0.2 (IU/L) increase in basal LH: B = 0.2*1.63 = 0.326
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BMC Endocrine Disorders

ISSN: 1472-6823

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