Skip to main content
Fig. 2 | BMC Endocrine Disorders

Fig. 2

From: Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus

Fig. 2

Effects of regulatory variants on GATA4 gene promoter activity. a. GATA4 gene promoter activities in HEK-293 cells. b. GATA4 gene promoter activities in INS-1 cells. The cultured cells were transfected with expression vector, and dual-luciferase reporter assay was performed. Wild type GATA4 gene promoter activity was set as 100%. The relative activity of variant GATA4 gene promoters was obtained. Lanes 1, pGL3-basic; 2, pGL3-WT; 3, pGL3-31,403 T; 4, pGL3-31487G; 5, pGL3-31566C; 6, pGL3-31567G; 7, pGL3-32,124 T. WT, wild type. *, P < 0.01

Back to article page