Table 4 Genotypic relationship between IL-6 (-174) G/C and IL-10 (-1082) G/A gene polymorphism and the odds of developing T2DM, North West Ethiopia, 2018 (n = 150)
Genotype | T2DM (N = 75) N (%) | Controls (N = 75) N (%) | P-value | OR (95%CI) |
|---|---|---|---|---|
IL-6 (−174) | ||||
GG | 38 (50.7) | 16 (23.3) | 4.61 (2.07–10.54) | |
GC | 20 (26.7) | 26 (34.7) | 0.001* | 1.49 (0.65–3.411) |
CC | 17 (22.7) | 33 (44) | - (ref) | |
IL-10 (−1082) | ||||
AA | 6 (8) | 12 (16) | 0.30 (0.101–0.892) | |
AG | 24 (32) | 36 (48) | 0.012* | 0.40 (0.198–0.808) |
GG | 45 (60) | 27 (36) | - (ref) | |