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Table 4 The enriched pathway terms of the up and down regulated differentially expressed genes

From: Investigation of candidate genes and mechanisms underlying obesity associated type 2 diabetes mellitus using bioinformatics analysis and screening of small drug molecules

Pathway ID

Pathway Name

P-value

FDR B&H

FDR B&Y

Bonferroni

Gene Count

Gene

Up regulated genes

 1269340

Hemostasis

4.28E-06

7.47E-04

5.11E-03

2.24E-03

22

GNG8,TRPC6,CEACAM6,CABLES1,SERPINE2,FGA,KCNMB1,FGB,HRG,PLA2G4A,MMP1,FGG,VEGFC,GRB14,APOB,APOH,ZFPM2,TGFB3,ORM1,TIMP1,CD63,PRKAR1B

 1269741

Cell Cycle

8.91E-04

2.12E-02

1.45E-01

4.67E-01

17

CETN2,MND1,MCM10,GINS1,TYMS,H2BC17,H4C14,BUB1,H2BC11,UBE2C,H4C15,CENPU,E2F1,CCNB1,DMC1,CENPI,H2AJ

 1269507

Signaling by Rho GTPases

1.14E-02

8.42E-02

5.76E-01

1.00E+00

11

PPP1R14A,TAX1BP3,H2BC17,H4C14,BUB1,WASF1,H2BC11,H4C15,CENPU,CENPI,H2AJ

 1269203

Innate Immune System

7.89E-02

2.91E-01

1.00E+00

1.00E+00

21

CEACAM6,DEFA1,GLA,HP,VNN1,FGA,FGB,FGG,WASF1,PGLYRP1,APOB,RET,LCN2,POLR3G,DERA,ORM1,MS4A3,CYSTM1,CD63,PRKAR1B,MCEMP1

 1270001

Metabolism of lipids and lipoproteins

1.52E-01

3.82E-01

1.00E+00

1.00E+00

13

ACER2,ACOT7,ME1,GLA,SPHK1,PLA2G4A,FHL2,PLAAT1,G0S2,THEM5,APOA2,APOB,SMPD1

 1268677

Metabolism of proteins

3.37E-01

5.01E-01

1.00E+00

1.00E+00

21

GNG8,CETN2,FN3K,H2AC13,H2BC17,VNN1,SPHK1,H4C14,MITF,FGA,MMP1,RAB32,METTL22,DYNC1I1,H2BC11,ADAMTS1,UBE2C,H4C15,ADAMTS5,IGFBP2,AOPEP

Down regulated genes

 1269171

Adaptive Immune System

1.59E-03

8.64E-02

5.87E-01

7.96E-01

20

HLA-DMB,HLA-DPA1,HLA-DRA,TNRC6B,ITGA4,NR4A1,BLK,KLHL3,PTPRC,MRC2,FBXO7,RNF213,BTLA,CBLB,CD4,CD22,CLEC2D,CD79A,CTSB,RNF182

 1269903

Transmembrane transport of small molecules

1.39E-02

1.95E-01

1.00E+00

1.00E+00

15

ABCA2,SLC38A5,SLC38A1,SLC24A4,ABCD2,GNG7,ATP13A1,SLC7A6,MCOLN1,SLC2A1,RHAG,SLC4A1,TFRC,SLC14A1,ATP2B1

 1269203

Innate Immune System

8.82E-02

4.76E-01

1.00E+00

1.00E+00

21

RPS6KA5,SPTA1,TNRC6B,NR4A1,ADA2,FGL2,PTPRC,CAMK4,DUSP2,NLRP1,CNKSR2,CR1,EEF1A1,TXNIP,EEF2,CD4,IGF2R,CD44,HBB,CTSB,NCKAP1L

 1269876

Vesicle-mediated transport

1.54E-01

5.50E-01

1.00E+00

1.00E+00

11

SPTA1,SEC16A,COL7A1,AAK1,TFRC,CD4,IGF2R,LRP1,HBA1,HBA2,HBB

 1268854

Disease

3.21E-01

6.43E-01

1.00E+00

1.00E+00

12

RPL23A,RPL27A,RPL37,NR4A1,NOTCH2,CNKSR2,EEF2,CD4,VCAN,NEURL1,RPL13A,RPL10

 1268677

Metabolism of proteins

5.53E-01

7.60E-01

1.00E+00

1.00E+00

19

RPL23A,RPL27A,RPL37,SPTA1,MGAT4A,NEU3,ADA2,TUBB1,YOD1,SEC16A,GNG7,KLK1,COL7A1,OGT,EEF1A1,EEF2,RPL13A,RPL10,SORL1