From: Identification of hub genes related to the progression of type 1 diabetes by computational analysis
Regulation | Node | Degree | Betweenness | Stress | Closeness |
---|---|---|---|---|---|
Up | EGFR | 1343 | 0.514227 | 4.35E+08 | 0.441893 |
Up | GRIN2B | 195 | 0.008701 | 14,535,992 | 0.282164 |
Up | GJA1 | 170 | 0.03151 | 64,939,702 | 0.31364 |
Up | CAP2 | 108 | 0.004218 | 888,128 | 0.325945 |
Up | MIF | 99 | 0.025028 | 7,627,912 | 0.362124 |
Up | DCC | 98 | 0.009465 | 15,166,420 | 0.286956 |
Up | PRL | 89 | 0.001208 | 656,482 | 0.239894 |
Up | EYA1 | 72 | 0.003864 | 4,335,792 | 0.271944 |
Up | RGS4 | 63 | 0.003414 | 1,243,420 | 0.31129 |
Up | GRIA4 | 55 | 0.001352 | 431,502 | 0.292547 |
Up | CCL19 | 50 | 0.001236 | 1,457,894 | 0.1951 |
Up | DKK1 | 50 | 0.003569 | 4,044,234 | 0.25252 |
Up | PLN | 43 | 0.003324 | 524,170 | 0.286083 |
Up | GPR37 | 41 | 0.021208 | 9,337,328 | 0.303261 |
Up | LRP2 | 39 | 0.023544 | 9,018,868 | 0.307583 |
Up | PTHLH | 38 | 0.001269 | 1,103,574 | 0.257729 |
Up | PPFIA2 | 33 | 0.002618 | 3,942,042 | 0.269956 |
Up | KIF1A | 31 | 0.011317 | 2,986,868 | 0.345485 |
Up | HOXB7 | 31 | 0.002165 | 2,106,446 | 0.268893 |
Up | MYOT | 28 | 0.003103 | 475,758 | 0.275841 |
Up | OTX2 | 28 | 0.003016 | 868,076 | 0.271263 |
Up | NPPC | 27 | 0.003211 | 986,326 | 0.247419 |
Up | KRT20 | 26 | 0.005296 | 5,544,830 | 0.279444 |
Up | MRPL12 | 25 | 0.050618 | 70,486,194 | 0.310399 |
Up | NPBWR1 | 23 | 4.01E-04 | 207,170 | 0.174777 |
Up | TRHR | 22 | 4.10E-04 | 210,106 | 0.238152 |
Up | CCL13 | 20 | 0.003552 | 1,650,164 | 0.263645 |
Up | MFAP2 | 19 | 0.002005 | 451,990 | 0.228053 |
Up | TRIM55 | 18 | 0.021705 | 17,474,648 | 0.300609 |
Up | NEUROG3 | 18 | 0.011467 | 9,544,416 | 0.269256 |
Up | NRAP | 18 | 0.001974 | 406,892 | 0.285085 |
Up | PTPRT | 18 | 0.00104 | 208,946 | 0.324523 |
Up | OSR1 | 17 | 4.56E-04 | 195,068 | 0.226447 |
Up | EFS | 17 | 0.003557 | 2,975,070 | 0.285232 |
Up | HBZ | 17 | 0.006623 | 4,433,868 | 0.287818 |
Up | KCNK4 | 16 | 4.01E-04 | 117,736 | 0.247125 |
Up | AVP | 16 | 0.006488 | 3,769,102 | 0.26391 |
Up | SOX18 | 16 | 8.04E-04 | 761,526 | 0.244028 |
Up | NACA2 | 15 | 0.002639 | 3,304,692 | 0.274822 |
Up | SRXN1 | 15 | 0.005715 | 9,265,020 | 0.276852 |
Up | UTF1 | 13 | 1 | 12 | 1 |
Up | RNF180 | 13 | 4.01E-04 | 186,722 | 0.235697 |
Up | KRT38 | 12 | 0.011531 | 15,515,646 | 0.273676 |
Up | FAP | 12 | 0.005985 | 10,442,836 | 0.259379 |
Up | GULP1 | 12 | 0.001542 | 1,584,446 | 0.281416 |
Up | IL17B | 12 | 4.02E-04 | 151,558 | 0.24843 |
Up | CRHR2 | 11 | 0.002005 | 1,044,220 | 0.245978 |
Up | RFPL4A | 10 | 9.09E-06 | 2638 | 0.1894 |
Up | SNAP91 | 10 | 0.001514 | 2,227,728 | 0.265994 |
Up | ADGRL4 | 10 | 0 | 0 | 0 |
Up | FBXO10 | 10 | 0.002727 | 598,280 | 0.287801 |
Up | CST6 | 9 | 0.009382 | 6,670,420 | 0.28234 |
Up | PADI3 | 9 | 0.003682 | 1,684,994 | 0.267321 |
Up | LIPF | 9 | 0.002462 | 1,222,458 | 0.239008 |
Up | CA10 | 8 | 0.00882 | 3,036,648 | 0.251628 |
Up | EPB41L4B | 8 | 0.00328 | 3,044,266 | 0.280229 |
Up | OR51E2 | 8 | 0.002481 | 1,735,460 | 0.249674 |
Up | RIMS4 | 8 | 4.46E-04 | 187,102 | 0.255497 |
Up | MYT1L | 8 | 1.71E-04 | 156,968 | 0.255523 |
Up | C4orf48 | 7 | 4.02E-04 | 410,864 | 0.238654 |
Up | EMILIN3 | 7 | 0.002789 | 890,368 | 0.2335 |
Up | CSNK1A1L | 6 | 0.002373 | 3,707,900 | 0.264526 |
Up | ATP1A4 | 6 | 0.001778 | 1,343,858 | 0.269795 |
Up | OR6C70 | 6 | 0 | 0 | 1 |
Up | MEIOB | 6 | 1.19E-04 | 55,294 | 0.237857 |
Up | UPK1B | 5 | 0.001266 | 639,316 | 0.238883 |
Up | TEX15 | 5 | 8.47E-04 | 384,696 | 0.261104 |
Up | CAMK1G | 5 | 0.001061 | 955,066 | 0.263353 |
Up | FOXQ1 | 5 | 0.02441 | 34,422,300 | 0.29497 |
Up | MYH13 | 4 | 0.007248 | 6,307,480 | 0.276193 |
Up | MYH6 | 4 | 0.006387 | 8,432,142 | 0.276223 |
Up | SPATA22 | 4 | 0.001497 | 616,922 | 0.255628 |
Up | TRHDE | 4 | 0.004478 | 568,880 | 0.325562 |
Up | CCDC144A | 4 | 0.001246 | 906,138 | 0.212789 |
Up | PCDHB10 | 4 | 8.03E-04 | 313,938 | 0.212698 |
Up | CNMD | 4 | 0.001108 | 411,030 | 0.251134 |
Up | ABRA | 4 | 0.001639 | 940,076 | 0.263019 |
Up | MS4A5 | 4 | 0 | 0 | 0.246088 |
Up | DNAH3 | 3 | 5.51E-04 | 333,004 | 0.269839 |
Up | MTRNR2L1 | 3 | 9.66E-04 | 646,606 | 0.269168 |
Up | KPNA7 | 3 | 4.63E-04 | 356,676 | 0.259541 |
Up | CBLN2 | 3 | 0 | 0 | 1 |
Up | FSIP2 | 3 | 4.14E-04 | 158,112 | 0.250276 |
Up | SPATA16 | 3 | 0 | 0 | 0.237426 |
Up | ZNF214 | 2 | 0.004409 | 2,022,086 | 0.235753 |
Up | CCDC140 | 2 | 4.01E-04 | 96,422 | 0.215353 |
Up | UGT2A3 | 2 | 8.95E-04 | 518,942 | 0.239952 |
Up | FAM71D | 2 | 4.04E-04 | 236,600 | 0.24016 |
Up | GOLGA6B | 2 | 0 | 0 | 0.221585 |
Up | C2orf73 | 2 | 8.02E-04 | 393,150 | 0.236301 |
Up | GOLGA8G | 2 | 0 | 0 | 1 |
Up | SMCO1 | 1 | 4.28E-04 | 175,370 | 0.225341 |
Up | ANKRD30B | 1 | 0 | 0 | 1 |
Up | FCAMR | 1 | 0 | 0 | 0.225719 |
Up | HFM1 | 1 | 8.96E-05 | 46,366 | 0.226673 |
Up | BTBD18 | 1 | 0 | 0 | 0.306486 |
Up | ACSBG2 | 1 | 4.02E-04 | 116,692 | 0.247358 |
Up | KRT39 | 1 | 0 | 0 | 0.251806 |
Up | G6PC | 1 | 0.001203 | 289,260 | 0.215428 |
Up | RBM46 | 1 | 1.99E-06 | 1374 | 0.252879 |
Up | PCDHB2 | 1 | 0 | 0 | 1 |
Up | AS3MT | 1 | 0 | 0 | 0.210364 |
Up | RAD21L1 | 1 | 0 | 0 | 1 |
Up | CAPN9 | 1 | 2.61E-06 | 2714 | 0.211893 |
Up | FABP6 | 1 | 0 | 0 | 1 |
Down | POLR2A | 512 | 0.095104 | 2E+08 | 0.3738 |
Down | PRKACA | 350 | 0.104658 | 44,280,174 | 0.378052 |
Down | GABARAP | 322 | 0.144708 | 36,234,824 | 0.358401 |
Down | TLN1 | 223 | 0.027406 | 67,578,124 | 0.35998 |
Down | PXN | 173 | 0.029203 | 29,047,866 | 0.360318 |
Down | HIP1 | 146 | 0.007469 | 12,022,620 | 0.347944 |
Down | GAB2 | 118 | 0.014217 | 38,718,180 | 0.340041 |
Down | SYVN1 | 114 | 0.025941 | 12,050,404 | 0.307887 |
Down | KCNIP2 | 110 | 0.002849 | 14,186,360 | 0.253084 |
Down | ARHGAP1 | 106 | 0.011263 | 27,047,958 | 0.348406 |
Down | NECTIN1 | 102 | 0.003189 | 17,978,038 | 0.252469 |
Down | RGL2 | 88 | 0.003069 | 3,605,218 | 0.263534 |
Down | ASF1B | 85 | 0.00926 | 21,237,598 | 0.2861 |
Down | IGF2R | 78 | 0.010589 | 26,691,414 | 0.303021 |
Down | SLC9A1 | 75 | 0.009561 | 24,396,634 | 0.292461 |
Down | VPS37C | 75 | 0.006908 | 5,646,832 | 0.29327 |
Down | MEFV | 72 | 0.001361 | 31,003,730 | 0.301081 |
Down | CDKN2A | 72 | 0.051693 | 14,128,370 | 0.321613 |
Down | MAP1A | 63 | 0.008662 | 3,403,950 | 0.291879 |
Down | ARF3 | 60 | 0.004127 | 11,523,596 | 0.287784 |
Down | CIITA | 59 | 0.006319 | 10,301,788 | 0.302892 |
Down | WDTC1 | 57 | 0.005909 | 19,161,622 | 0.278569 |
Down | MICALL1 | 53 | 0.005986 | 7,902,576 | 0.285919 |
Down | ITGAX | 53 | 0.001212 | 13,088,030 | 0.238757 |
Down | SORBS3 | 51 | 0.016308 | 10,468,808 | 0.314749 |
Down | DSP | 47 | 0.039735 | 2,314,856 | 0.347581 |
Down | BAZ2A | 45 | 0.004013 | 13,101,300 | 0.289472 |
Down | MAPRE3 | 44 | 0.006813 | 4,554,084 | 0.28533 |
Down | CRTC2 | 44 | 0.004812 | 11,994,716 | 0.296709 |
Down | PADI4 | 43 | 0.002174 | 7,728,076 | 0.275765 |
Down | SPINT1 | 42 | 0.001717 | 6,257,478 | 0.263492 |
Down | ARHGEF5 | 40 | 0.003561 | 7,025,544 | 0.336483 |
Down | LASP1 | 40 | 0.021943 | 9,410,452 | 0.31303 |
Down | PDZD3 | 39 | 0.005273 | 6,150,510 | 0.249549 |
Down | HIVEP3 | 39 | 0.001859 | 4,355,942 | 0.26672 |
Down | TNFRSF21 | 36 | 0.001781 | 3,131,524 | 0.274883 |
Down | SOGA1 | 36 | 0.005248 | 10,217,032 | 0.291623 |
Down | MBD6 | 34 | 0.002017 | 1,737,436 | 0.231979 |
Down | ATP6V0D1 | 33 | 0.026324 | 1,957,202 | 0.303649 |
Down | IQCN | 32 | 0.015047 | 5,650,026 | 0.283239 |
Down | IL17RA | 30 | 0.020601 | 4,651,714 | 0.286807 |
Down | ABTB2 | 29 | 0.001793 | 4,772,698 | 0.279695 |
Down | INCA1 | 29 | 0.011463 | 2,924,018 | 0.276668 |
Down | MAST3 | 28 | 0.019115 | 4,567,048 | 0.308592 |
Down | BEST1 | 28 | 4.42E-04 | 3,684,990 | 0.260082 |
Down | PRSS21 | 28 | 0.001117 | 5,817,460 | 0.25749 |
Down | TPCN2 | 27 | 0.014228 | 4,144,602 | 0.284792 |
Down | LAG3 | 26 | 4.41E-06 | 6,746,636 | 0.238038 |
Down | GMIP | 24 | 8.12E-04 | 3,636,310 | 0.263896 |
Down | CLEC4C | 24 | 4.01E-04 | 725,910 | 0.175956 |
Down | TAGLN | 23 | 0.016019 | 4,532,938 | 0.283771 |
Down | FAM219A | 20 | 0.008105 | 916,962 | 0.287867 |
Down | NCR1 | 20 | 0.002234 | 349,872 | 0.271381 |
Down | PRRC2A | 18 | 0.015874 | 2,767,592 | 0.307261 |
Down | KCNMB1 | 18 | 8.42E-04 | 2,984,594 | 0.257118 |
Down | EIF3CL | 17 | 0.003808 | 1,129,844 | 0.284272 |
Down | H6PD | 17 | 5.55E-04 | 3,133,402 | 0.259123 |
Down | MMP25 | 17 | 4.01E-04 | 2,598,252 | 0.238837 |
Down | ENTPD2 | 16 | 1 | 2,170,770 | 1 |
Down | DYSF | 16 | 0.009592 | 704,606 | 0.292839 |
Down | LGALS9 | 16 | 0.01981 | 1,417,206 | 0.288134 |
Down | DPEP2 | 16 | 0.007617 | 1,500,838 | 0.260885 |
Down | POMZP3 | 14 | 8.35E-05 | 836,800 | 0.254857 |
Down | EXTL3 | 13 | 0.004948 | 611,924 | 0.27899 |
Down | EPHX1 | 13 | 0.006221 | 2,003,020 | 0.279491 |
Down | C15orf39 | 12 | 0.00794 | 610,110 | 0.291793 |
Down | PLXNA2 | 12 | 0.009415 | 1,162,970 | 0.277268 |
Down | PLPPR2 | 12 | 0.006567 | 1,448,934 | 0.253961 |
Down | MYADM | 11 | 0.007222 | 952,256 | 0.283771 |
Down | GTPBP1 | 11 | 0.005922 | 1,877,862 | 0.299976 |
Down | ADGRE5 | 10 | 0.014659 | 888,184 | 0.289203 |
Down | SULT1A2 | 10 | 0.00172 | 1,783,464 | 0.247973 |
Down | INKA2 | 10 | 0.00214 | 1,184,052 | 0.279616 |
Down | NDST1 | 10 | 0.001942 | 1,716,840 | 0.257383 |
Down | TTLL3 | 9 | 0.002348 | 134,132 | 0.261694 |
Down | DRICH1 | 9 | 0.002408 | 1,799,342 | 0.237302 |
Down | APOL2 | 9 | 0.007736 | 489,254 | 0.289489 |
Down | ZNF70 | 9 | 0.001286 | 3,985,632 | 0.223763 |
Down | ASPRV1 | 9 | 0.00395 | 1,038,668 | 0.290552 |
Down | PLXNA4 | 8 | 0.001243 | 473,354 | 0.262534 |
Down | FAM160A1 | 8 | 4.10E-04 | 882,848 | 0.241043 |
Down | PLBD2 | 8 | 0.002764 | 1,265,098 | 0.278057 |
Down | RNF122 | 8 | 0.001044 | 1,049,362 | 0.265329 |
Down | PAQR6 | 8 | 4.10E-04 | 868,456 | 0.23693 |
Down | CHKB | 7 | 0 | 602,254 | 0.217363 |
Down | CRISPLD2 | 7 | 3.80E-06 | 943,864 | 0.256153 |
Down | DUSP18 | 7 | 0.002971 | 325,170 | 0.315506 |
Down | TRANK1 | 7 | 4.02E-04 | 801,248 | 0.245821 |
Down | TP53INP2 | 6 | 1.70E-07 | 703,508 | 0.247198 |
Down | ARAP3 | 6 | 4.92E-04 | 286,916 | 0.268169 |
Down | TNFAIP2 | 6 | 0.001439 | 633,692 | 0.254324 |
Down | APOL1 | 5 | 6.25E-04 | 48,364 | 0.233895 |
Down | PRR16 | 5 | 0.001298 | 158,878 | 0.26692 |
Down | ITIH4 | 5 | 4.46E-04 | 356,728 | 0.266806 |
Down | SIGLEC14 | 5 | 0 | 273,222 | 1 |
Down | C5AR2 | 5 | 0.019084 | 54,700 | 0.270983 |
Down | DTX4 | 5 | 8.06E-04 | 445,430 | 0.256483 |
Down | SCAMP5 | 5 | 0.002526 | 469,900 | 0.229016 |
Down | SH3D21 | 5 | 1.03E-04 | 675,458 | 0.314928 |
Down | LY6G5B | 4 | 6.87E-04 | 43,440 | 0.259947 |
Down | TMEM121B | 4 | 0 | 217,638 | 0.1804 |
Down | AOC3 | 4 | 0.002207 | 251,106 | 0.268748 |
Down | DAAM2 | 3 | 0.00264 | 78,488 | 0.259838 |
Down | ZBTB3 | 3 | 0.006264 | 225,562 | 0.267838 |
Down | LCNL1 | 3 | 9.23E-05 | 198,214 | 0.235286 |
Down | RIMS3 | 2 | 4.16E-04 | 11,332 | 0.223944 |
Down | ZNF385A | 2 | 6.60E-04 | 3498 | 0.264948 |
Down | RIPOR1 | 2 | 6.43E-04 | 1512 | 0.277964 |
Down | KDM6B | 2 | 0.003441 | 321,702 | 0.271411 |
Down | PAPLN | 2 | 0.001857 | 53,928 | 0.244759 |
Down | RAB36 | 2 | 4.01E-04 | 4276 | 0.188797 |
Down | NOMO2 | 2 | 5.94E-04 | 78 | 0.280182 |
Down | AOC2 | 2 | 5.51E-04 | 3886 | 0.250113 |
Down | PROSER3 | 2 | 4.60E-05 | 2 | 0.23941 |
Down | WDFY4 | 2 | 2.38E-06 | 184,474 | 0.236975 |
Down | ATG16L2 | 2 | 0.001016 | 322,434 | 0.299651 |
Down | RAPGEFL1 | 2 | 7.68E-05 | 9928 | 0.260599 |
Down | CPNE9 | 1 | 9.19E-05 | 0 | 0.23639 |
Down | RSKR | 1 | 4.69E-06 | 0 | 0.247739 |
Down | RGL3 | 1 | 0 | 0 | 0.234621 |
Down | SHISA4 | 1 | 0 | 0 | 1 |
Down | TMEM63C | 1 | 0 | 0 | 0.24945 |
Down | NPIPB3 | 1 | 8.84E-06 | 0 | 0.229639 |
Down | CLEC17A | 1 | 0 | 0 | 0.209331 |
Down | TIFAB | 1 | 0 | 0 | 1 |
Down | OSCAR | 1 | 0 | 0 | 1 |
Down | AGAP9 | 1 | 0 | 0 | 0.236256 |