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Table 3 Effect of high risk factors for type 2 diabetes mellitus on NXK6.1 Ins+ cells and NKX6.1cyt Ins + cells per islet in pancreas

From: Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

  NXK6.1Nuc-Ins+ cells /islet NXK6.1Nuc-Ins+ /ins+ (%) NXK6.1cytIns cells /islet NXK6.1cytIns cells /islet (%)
HbA1c (%)
  < 5.7% 10.45 ± 0.91 16.31 ± 1.15 2.95 ± 0.55 3.57 ± 0.69
 5.7–6.4% 9.00 ± 1.67 16.68 ± 2.40 2.04 ± 0.91 2.84 ± 1.15
Age (years)
 30–39 9.32 ± 4.20 13.19 ± 3.56 3.05 ± 1.16 3.66 ± 1.38
 40–49 11.63 ± 0.92 18.20 ± 1.16 2.71 ± 0.82 3.24 ± 1.00
 50–59 8.95 ± 1.29 15.72 ± 2.02 2.16 ± 0.58 3.00 ± 0.81
 60–79 8.57 ± 2.07 14.40 ± 4.03 4.67 ± 2.07 5.34 ± 2.64
BMI (kg/m2)
  < 23 12.64 ± 1.64 18.46 ± 1.35 3.10 ± 0.87 3.80 ± 1.15
 23–25 9.69 ± 1.71 15.90 ± 2.21 3.65 ± 1.81 4.39 ± 2.21
 25–30 9.41 ± 1.24 15.92 ± 1.96 2.45 ± 0.69 3.05 ± 0.85
  ≥ 30 8.18 ± 1.85 14.40 ± 2.73 1.98 ± 0.53 2.61 ± 0.67
  1. Data are shown as mean ± SEM. No significant difference was observed between different groups