Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

Table 3 Effect of high risk factors for type 2 diabetes mellitus on NXK6.1 Ins⁺ cells and NKX6.1cyt Ins + cells per islet in pancreas

	NXK6.1^Nuc-Ins⁺ cells /islet	NXK6.1^Nuc-Ins⁺ /ins⁺ (%)	NXK6.1^cytIns⁻ cells /islet	NXK6.1^cytIns⁻ cells /islet (%)
HbA1c (%)
< 5.7%	10.45 ± 0.91	16.31 ± 1.15	2.95 ± 0.55	3.57 ± 0.69
5.7–6.4%	9.00 ± 1.67	16.68 ± 2.40	2.04 ± 0.91	2.84 ± 1.15
Age (years)
30–39	9.32 ± 4.20	13.19 ± 3.56	3.05 ± 1.16	3.66 ± 1.38
40–49	11.63 ± 0.92	18.20 ± 1.16	2.71 ± 0.82	3.24 ± 1.00
50–59	8.95 ± 1.29	15.72 ± 2.02	2.16 ± 0.58	3.00 ± 0.81
60–79	8.57 ± 2.07	14.40 ± 4.03	4.67 ± 2.07	5.34 ± 2.64
BMI (kg/m2)
< 23	12.64 ± 1.64	18.46 ± 1.35	3.10 ± 0.87	3.80 ± 1.15
23–25	9.69 ± 1.71	15.90 ± 2.21	3.65 ± 1.81	4.39 ± 2.21
25–30	9.41 ± 1.24	15.92 ± 1.96	2.45 ± 0.69	3.05 ± 0.85
≥ 30	8.18 ± 1.85	14.40 ± 2.73	1.98 ± 0.53	2.61 ± 0.67

Data are shown as mean ± SEM. No significant difference was observed between different groups

ISSN: 1472-6823