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Fig. 2 | BMC Endocrine Disorders

Fig. 2

From: Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes

Fig. 2

Representative immunofluorescence images of pancreatic sections of non-diabetic (ND) subjects and T2DM subjects. a Representative images of immunostaining with Insulin and NKX6.1 in the pancreatic sections of non-diabetic (ND) subjects and T2DM subjects. White arrows marked dedifferentiated β cells with NKX6.1 dislocation. Scale bar: 20 μm, Red: NKX6.1, Green: Ins, Blue: DAPI. b Quantification of NKX6.1Nuc-Ins+ cell count and percentage in β cells. c Quantification of NKX6.1cytIns− cell count and percentage per islet. d Correlation between NKX6.1Nuc-Ins+ cells per islet with HbA1c in T2DM subjects (Simple linear regression). n = 40 for non-diabetic (ND) subjects; n = 20 for T2DM subjects. Data were shown as mean ± SEM. *P < 0.05. ***P < 0.001

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BMC Endocrine Disorders

ISSN: 1472-6823

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