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Table 4 Summary of mean difference with 95% confidence intervals (CI) between neonatal head-circumference and pediatric cognitive outcomes in pregnant women with subclinical hypothyroidism treated with and without levothyroxine

From: Levothyroxine and the risk of adverse pregnancy outcomes in women with subclinical hypothyroidism: a systematic review and meta-analysis

Outcomes

Unit of measure

No. of Studies

Pooled Sample

Mean Difference

(95% CI)

Neonatal

 Neonatal head circumference (at birth)

cm

2

1031

−0.042 (−0.67 to 0.58)

Pediatric

 Child Behaviour Checklist T-score at 3

years old

percentile

2

1409

−0.50 (−4.5 to 3.5)

 IQ at 3 to 5 years old

percentile

2

1443

0.94 (−23 to 25)