Fig. 2

Skin autofluorescence, as measured by the autofluorescence reader AGE reader mu connect (Diagnoptics, NL). Local creams should not have been applied for 12 h. The examinee places the forearm of his/her dominant upper limb on the silicone armrest of the device. In this armrest, there is a small examination window for selection of a skin area. The elbow should be aligned with the edge of the armrest and no movements should be made during measurement. The examiner switches on the device using the power button. Activation is performed through the menu on the touch screen. AGEs result is shown on the screen. Approximate measurement duration is 30 s. Interpretation of results may be facilitated by available age- and sex-adjusted normative data