Skip to main content
Fig. 1 | BMC Endocrine Disorders

Fig. 1

From: Skin AGEs and diabetic neuropathy

Fig. 1

The contribution of AGEs to the pathogenesis of diabetic neuropathy. A major mechanism includes activation of the polyol pathway, leading to NADPH depletion and increased production of reactive oxygen species (ROS). The latter contribute to AGEs accumulation. AGEs act via the receptor of advanced glycation end products (RAGE), promote neural inflammation, impair neuronal electrical activity and induce unfavourable gene changes. These perturbations, along with direct neuronal toxicity from intracellular sorbitol accumulation, culminate in diabetic neuropathy. AGEs: advanced glycation end products; NADPH: Nicotinamide adenine dinucleotide phosphate; RAGE: receptor of advanced glycation end products; ROS: reactive oxygen species

Back to article page