Skip to main content
Fig. 4 | BMC Endocrine Disorders

Fig. 4

From: Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis

Fig. 4

Overexpressed NEU1 reversed the effects of upregulated miR-23b-3p in obesity-induced IR of mice. a Body weight of mice after obesity-induced IR model construction and injection of lentivirus carriers for miR-23b-3p mimic and NEU1 overexpression plasmid was measured. b Fat percent of mice after obesity-induced IR model construction and injection of lentivirus carriers for miR-23b-3p mimic and NEU1 overexpression plasmid was calculated. c-d Levels of fasting blood glucose (c) and fasting insulin (d) after obesity-induced IR model construction and injection of lentivirus carriers for miR-23b-3p mimic and NEU1 overexpression plasmid were determined. e-f AUC of mice for OGTT (e) and ITT (f) after obesity-induced IR model construction and injection of lentivirus carriers for miR-23b-3p mimic and NEU1 overexpression plasmid was quantified. All experiments have been performed in triplicate and data were expressed as mean ± standard deviation (SD). *P < 0.05, **P < 0.01, ***P < 0.001, vs. Control; ^P < 0.05, ^^P < 0.01, ^^^P < 0.001, vs. MC; ##P < 0.01, ###P < 0.001, vs. NC; ΔP < 0.05, ΔΔP < 0.01, ΔΔΔP < 0.001, vs. M; ξξP < 0.01, ξξξP < 0.001, vs. NEU1

Back to article page