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Table 2 Correlation between the gene expression of SIRT2, FBXW5 and CPT1B analyzed with quantitative PCR (QPCR) with the QPCR expression values of SIRT2, FBXW5, CPT1B, key genes involved in transport and mitochondrial uptake and oxidation of fatty acids in skeletal muscle (FABP3 and MLYCD) and genes with central roles in regulating mitochondrial biogenesis and oxidative phosphorylation in muscle (PPARGC1A and ESRRA). Significant correlation was determined using Spearman’s rank correlation coefficient test

From: Relationship between insulin sensitivity and gene expression in human skeletal muscle

  SIRT2 FBXW5 CPT1B
SIRT2 Spearman’s rank correlation coefficient 0.81 0.71
P <  0.001 <  0.001
n 36 35
FBXW5 Spearman’s rank correlation coefficient 0.81 0.60
P <  0.001 <  0.001
n 36 35
CPT1B Spearman’s rank correlation coefficient 0.71 0.60
P <  0.001 <  0.001
n 35 35
FABP3 Spearman’s rank correlation coefficient 0.54 0.49 0.75
P 0.001 0.003 <  0.001
n 35 35 37
MLYCD Spearman’s rank correlation coefficient 0.66 0.59 0.76
P <  0.001 <  0.001 <  0.001
n 35 35 37
PPARGC1A Spearman’s rank correlation coefficient 0.44 0.46 0.66
P 0.009 0.005 <  0.001
n 35 35 37
ESRRA Spearman’s rank correlation coefficient 0.67 0.66 0.69
P <  0.001 <  0.001 <  0.001
n 32 32 32
  1. Abbreviations: SIRT2, sirtuin 2; FBXW5, F-box and WD repeat domain containing 5; CPT1B, carnitine palmitoyltransferase 1B; PPARGC1A (PGC1α), peroxisome proliferator-activated receptor gamma coactivator 1-alpha; ESRRA, estrogen-related receptor alpha; MLYCD, malonyl-CoA decarboxylase; FABP3, fatty acid binding protein 3