Table 2 Correlation between the gene expression of SIRT2, FBXW5 and CPT1B analyzed with quantitative PCR (QPCR) with the QPCR expression values of SIRT2, FBXW5, CPT1B, key genes involved in transport and mitochondrial uptake and oxidation of fatty acids in skeletal muscle (FABP3 and MLYCD) and genes with central roles in regulating mitochondrial biogenesis and oxidative phosphorylation in muscle (PPARGC1A and ESRRA). Significant correlation was determined using Spearman’s rank correlation coefficient test

SIRT2

Spearman’s rank correlation coefficient

–

0.81

0.71

P

–

<  0.001

<  0.001

n

–

36

35

FBXW5

Spearman’s rank correlation coefficient

0.81

–

0.60

P

<  0.001

–

<  0.001

n

36

–

35

CPT1B

Spearman’s rank correlation coefficient

0.71

0.60

–

P

<  0.001

<  0.001

–

n

35

35

–

FABP3

Spearman’s rank correlation coefficient

0.54

0.49

0.75

P

0.001

0.003

<  0.001

n

35

35

37

MLYCD

Spearman’s rank correlation coefficient

0.66

0.59

0.76

P

<  0.001

<  0.001

<  0.001

n

35

35

37

PPARGC1A

Spearman’s rank correlation coefficient

0.44

0.46

0.66

P

0.009

0.005

<  0.001

n

35

35

37

ESRRA

Spearman’s rank correlation coefficient

0.67

0.66

0.69

P

<  0.001

<  0.001

<  0.001

n

32

32

32