From: Role of Artesunate on cardiovascular complications in rats with type 1 diabetes mellitus
Group | Mean optical density (MOD) | ||||
---|---|---|---|---|---|
RAGE | NF-κB | MMP9 | MMP1 | CD68 | |
Healthy | 1.972 ± 0.181 | 1.778 ± 0.793 | 2.019 ± 0.548 | 3.233 ± 0.290 | 1.058 ± 0.192 |
DM | 6.119 ± 0.984** | 6.219 ± 1.517** | 8.029 ± 1.563** | 6.875 ± 0.259** | 6.425 ± 1.179** |
DM + ART(50 mg/kg) | 3.189 ± 1.451*## | 1.796 ± 0.820## | 2.062 ± 0.401## | 3.330 ± 0.494## | 2.203 ± 1.602## |
DM + ART(100 mg/kg) | 2.435 ± 0.489## | 2.809 ± 1.092## | 7.787 ± 0.713** | 5.002 ± 0.702*# | 7.929 ± 0.827** |
DM + INS | 3.165 ± 0.636*## | 6.673 ± 2.364** | 4.900 ± 1.164**## | 4.095 ± 1.682## | 4.056 ± 1.613*# |