Outcomes of endoscopic transsphenoidal surgery for Cushing's disease

BMC Endocrine Disorders

Table 1 Summary of demographics and post-operative outcomes

Number of patients undergoing ETSS	39
Number of ETSS procedures	43
Age	37 (8–75)
Female	30 (77%)
Tumour visible on pre-op MRI Microadenoma Macroadenoma	22 (56%) 18 4
Pre-operative IPSS	33 (85%)
Postoperative remission, initial ETSS
Standard criteria^a	34 (87%)
Strict criteria^b	22 (58%)
Postoperative remission, including 3 patients with early repeat ETSS
Standard criteria^a	36 (92%)
Strict criteria^b	23 (61%)
Postoperative hypopituitarism
Transient diabetes insipidus	13 (33%)
Permanent diabetes insipidus	9 (23%)
TSH deficiency	5 (13%)
Gonadotrophin deficiency	4 (10%)
Recurrence	1

Data expressed as median (range) and number (percentage).
^a 0800 h serum cortisol < 138 nmol/l within seven days of operation and improvement in clinical features of hypercortisolism
^b Day 3 0800 h serum cortisol concentration < 50 nmol/L. Day 3 cortisol was not measured in one patient due to intercurrent illness requiring treatment with intravenous glucocorticoids

ISSN: 1472-6823