From: Predictors of dopamine agonist resistance in prolactinoma patients
Study population | Responsive group | Resistant group | ||
---|---|---|---|---|
Demographic factors | Patients | 69 | 58 | 11 |
Women | 52 | 46 | 6 | |
Men | 17 | 12 | 5 | |
Endocrinological factors | Baseline PRL [median (interquartile range)] | 116.98 μg/l (294,46) | 105.66 μg/l (284,17) | 259.77 μg/l (842,24) |
PRL after 3 months: Reduction [mean (standard deviation)] | 83.3% (20.56) | 67.5% (31,75) | ||
PRL after 3 months: Normalization | 62.0% | 70.5% | 0.0% | |
PRL after 4 months: Reduction [mean (standard deviation)] | 82.7% (22,85) | 87.4% (18,95) | 63.8% (30,32) | |
PRL after 4 months: Normalization | 79.0% | 87.5% | 0.0% | |
MRI factors | Tumour volume [median (interquartile range)] | 0.18 cm3 (1,32) | 0.13 cm3 (0,88) | |
Microadenoma | 54.4% | 59.6% | 27.3% | |
Macroadenoma | 45.6% | 40.4% | 72.7% | |
Contrast capitation [mean (standard deviation)] | 1.93 (0,81) | 1.88 (0,70) | 2.40 (1,43) | |
Presence of cystic/hemorraghic/necrotic component | 26.7% | 20.7% | 71.4% |