Table 3 Genotype frequencies of studied SNPs of the KISS1 gene, in PCOS patients and controls
SNPs | Genotypes | Frequency | OR (95%CI) | χ2 | p-value | ||
|---|---|---|---|---|---|---|---|
PCOS patients n (%) | Controls n (%) | Total n (%) | |||||
rs372790354 G/A | GG | 86 (82.7%) | 92 (84.4%) | 178 (83.6%) | Reference | ||
GA | 13 (12.5%) | 17 (15.6%) | 30 (14.1%) | 0.07 (0.01–1.38) | 5.51 | 0.018* | |
AA | 5 (4.8%) | 0 (0.0%) | 5 (2.3%) | 1.17 (0.64–215) | 5.20 | 0.022* | |
Total | 104 (100.0%) | 109 (100.0%) | 213 (100.0%) | Â | |||
rs12998 G/A | GG | 87 (83.7%) | 88 (80.7%) | 175 (82.2%) | Reference | ||
GA | 12 (11.5%) | 17 (15.6%) | 29 (13.6%) | 0.56 (0.13–2.55) | 0.56 | 0.454 | |
AA | 5 (4.8%) | 4 (3.7%) | 9 (4.2%) | 1.26 (0.33–4.86) | 0.12 | 0.732 | |
Total | 104 (100.0%) | 109 (100.0%) | 213 (100.0%) | Â | |||
rs35431622 A/T | AA | 97 (93.3%) | 101 (92.7%) | 198 (92.96%) | Reference | ||
AT | 7 (6.7%) | 8 (7.3%) | 15 (7.04%) | 0.91 (0.32–2.61) | 0.03 | 0.862 | |
TT | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | – | – | – | |
Total | 104 (100.0%) | 109 (100.0%) | 213 (100.0%) | Â | |||