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Table 1 Clinical and biochemical characteristics of the study subjects from different groups

From: Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders

Variables

NGT (n = 64)

IGT (n = 64)

P value

Agea

52.98 ± 6.39

53.58 ± 6.82

0.357

Sex, male/female (%)

32/32

32/32

1.000

BMI (kg/m2)a

25.15 ± 2.25

24.18 ± 2.62*

0.033

WHR

0.88 ± 0.06

0.88 ± 0.06

0.697

SBP (mmHg)

122.88 ± 14.04

125.05 ± 15.06

0.607

DBP (mmHg)

75.59 ± 11.89

73.09 ± 10.68

0.986

ALT (U/L)a

17.00 (14.00–23.00)

25.00 (16.25–29.75)*

0.003

AST (U/L)a

22.00 (18.00–24.00)

23.00 (20.00–26.75)

0.058

GGT (U/L)a

25.00 (18.00–36.75)

29.00 (21.00–43.00)

0.212

HbA1c (%)

5.63 ± 0.49

5.69 ± 0.43

0.280

TC (mmol/L)

5.27 ± 0.86

5.25 ± 0.95

0.611

TG (mmol/L)a

1.45 ± 0.87

1.80 ± 1.84

0.062

LDL cholesterol (mmol/L)

3.46 ± 0.86

3.37 ± 0.88

0.962

HDL cholesterol (mmol/L)a

1.28 ± 0.38

1.23 ± 0.37

0.618

SAT (cm2)a

170.75 (139.35–216.08)

152.55 (126.98–200.88)

0.120

VAT (cm2)a

86.97 (57.43–111.90)

94.22 (69.67–120.93)

0.363

VAT/SATa

0.47 (0.33–0.76)

0.52 (0.44–0.74)

0.084

BFR (%)a

25.30 (19.50–32.20)

26.30 (21.10–31.10)

0.940

LUR (%)

25.00 ± 8.07

24.61 ± 7.76

0.305

RUR (%)

24.48 ± 7.94

23.88 ± 7.71

0.396

LLR (%)

26.95 ± 9.56

26.25 ± 10.19

0.280

RLR (%)

26.92 ± 9.51

26.02 ± 10.47

0.169

FPG (mmol/L)a

5.20 (4.83–5.60)

5.10 (4.80–5.50)

0.460

2 h-PG (mmol/L)a

6.10 (5.00–6.90)

8.90 (8.40–9.60)*

0.000

FINS (μU/mL)a

7.96 (5.22–9.83)

8.64 (5.97–11.33)

0.157

HOMA-IRa

1.74 (1.19–2.41)

2.03 (1.38–2.61)

0.263

HOMA-βa

87.00 (64.55–119.05)

107.39 (70.54–146.16)

0.087

QUICKIa

0.35 (0.33–0.37)

0.34 (0.33–0.36)

0.230

Matsuda ISI

6.12 ± 3.36

4.72 ± 2.91*

0.013

Betatrophin (pg/mL)a

708.52 (562.72–895.82)

729.72 (543.09–1022.67)

0.443

  1. BMI Body mass index, WHR Waist-to-hip ratio, SBP Systolic blood pressure, DBP Diastolic blood pressure, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-glutamyl transpeptidase, TC Total cholesterol, TG Triglyceride, LDL Low-density lipoprotein cholesterol, HDL High-density lipoprotein cholesterol, SAT Subcutaneous adipose tissue, VAT Visceral adipose tissue, VAT/SAT Ratio visceral adipose tissue-to-subcutaneous adipose tissue ratio, BFR Body fat ratio, LUR Left upper limb fat ratio, RUR Right upper limb fat ratio, LLR Left lower limb fat ratio, RLR Right lower limb fat ratio, FPG Fasting plasma glucose, 2 h-PG 2 h-plasma glucose during oral glucose tolerance test, FINS Fasting blood insulin, HOMA-β Homeostasis model of β cell function, HOMA-IR Homeostasis Model of insulin resistance, QUICKI Quantitative insulin sensitivity check index, Matsuda ISI Matsuda insulin sensitivity index. Data are presented as the mean ± SD (normally distributed) or median (25th and 75th percentiles; non-normally distributed). Differences between groups were analyzed by ANOVA followed by the LSD test. Gender distribution differences were analyzed by χ2 analysis. * p < 0.05 vs. the NGT group. aNon-normally distributed data were transformed logarithmically for statistical analysis