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Table 1 Subject characteristics of the KCNQ1 R670K carrier (KCNQ1) and KCNE1 G60D carrier (KCNE1) and their BMI, sex and age matched control participants. Subject characteristics and fasting baseline of glucose and hormone levels of the mutation carriers and their matched control participants (n = 6), and baseline of ECG (n = 4), mean ± SD

From: Gain-of-function mutation in the voltage-gated potassium channel gene KCNQ1 and glucose-stimulated hypoinsulinemia - case report

 KCNQ1KCNE1Control
SexMaleMaleMale
Age484948 ± 1
BMI (kg/m2)28.020.724.7 ± 4.3
Fat percentage25.614.221.8 ± 5.8
HbA1c (mmol/mol)31.034.034.0 ± 3.6
Hgb (mmol/l)9.09.18.9 ± 0.8
Cholesterol (mmol/l)4.05.94.7 ± 0.7
Creatinine (μmol/l)627177 ± 7
ECG characteristics in fasting state
 QTcB (ms)434.6449.5410.5 ± 26.8
 QTcF (ms)427.8458.8417.9 ± 17.2
 Heart rate (beats/min.)66.453.554.7 ± 10.7
Fasting glucose and hormone levels
 Serum C-peptide (pmol/l)774403576 ± 301
 Serum Insulin (pmol/l)882142 ± 47
 Plasma total GIP (pmol/l)1579 ± 2
 Plasma total GLP-1 (pmol/l)181412 ± 2
 Plasma Glucagon (pmol/l)737 ± 4
 Plasma Glucose (mmol/l)5.65.25.1 ± 0.4