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Table 4 Prospective associations (hazard ratios) between leptin and adiponectin with incident type 2 diabetes stratified by abdominal obesity (as measured by waist circumference*)

From: Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

Abdominally non-obese (n = 1057)

 Type 2 diabetes cases (n = 91)

  Continuous Adipokines

Model 1†

Model 2‡

HR

95% CI

P

HR

95% CI

P

   Log Plasma leptin (ng/mL)

1.55

(1.02, 2.36)

0.04

0.92

(0.58, 1.45)

0.73

   Log Plasma adiponectin (ng/mL)

0.86

(0.60, 1.23)

0.40

1.18

(0.80, 1.73)

0.41

Abdominally obese (n = 1599)

 Type 2 diabetes cases (n = 364)

  Continuous Adipokines

Model 1†

Model 2‡

HR

95% CI

p

HR

95% CI

P

   Log Plasma leptin (ng/mL)

1.04

(0.81, 1.34)

0.75

0.82

(0.63, 1.07)

0.14

   Log Plasma adiponectin (ng/mL)

0.53

(0.44, 0.63)

<.0001

0.66

(0.54, 0.80)

<.0001

  1. *Waist circumference was dichotomized with sex-specific cut points as abdominally obese (men with waist circumference ≥ 102 cm and women with waist circumference ≥ 88 cm) and abdominally non-obese (men with waist circumference < 102 cm and women with waist circumference < 88 cm)
  2. †Model 1: Adjusted for sex, age, BMI, systolic blood pressure, antihypertension medication, triglycerides, HDL-cholesterol, antihyperlipidemic medication, smoking, alcohol consumption, physical activity, and education level
  3. ‡Model 2: Adjusted for model 1 variables and HOMA-IR