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Table 4 Prospective associations (hazard ratios) between leptin and adiponectin with incident type 2 diabetes stratified by abdominal obesity (as measured by waist circumference*)

From: Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

Abdominally non-obese (n = 1057)
Type 2 diabetes cases (n = 91)
  Continuous AdipokinesModel 1Model 2
HR95% CIPHR95% CIP
   Log Plasma leptin (ng/mL)1.55(1.02, 2.36)0.040.92(0.58, 1.45)0.73
   Log Plasma adiponectin (ng/mL)0.86(0.60, 1.23)0.401.18(0.80, 1.73)0.41
Abdominally obese (n = 1599)
Type 2 diabetes cases (n = 364)
  Continuous AdipokinesModel 1Model 2
HR95% CIpHR95% CIP
   Log Plasma leptin (ng/mL)1.04(0.81, 1.34)0.750.82(0.63, 1.07)0.14
   Log Plasma adiponectin (ng/mL)0.53(0.44, 0.63)<.00010.66(0.54, 0.80)<.0001
  1. *Waist circumference was dichotomized with sex-specific cut points as abdominally obese (men with waist circumference ≥ 102 cm and women with waist circumference ≥ 88 cm) and abdominally non-obese (men with waist circumference < 102 cm and women with waist circumference < 88 cm)
  2. †Model 1: Adjusted for sex, age, BMI, systolic blood pressure, antihypertension medication, triglycerides, HDL-cholesterol, antihyperlipidemic medication, smoking, alcohol consumption, physical activity, and education level
  3. ‡Model 2: Adjusted for model 1 variables and HOMA-IR