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Table 3 Prospective associations (hazard ratios) between leptin and adiponectin with incident type 2 diabetes stratified by BMI groups

From: Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

BMI < 25 kg/m2 (n = 416)
Type 2 diabetes cases (n = 28)
  Continuous AdipokinesModel 1*Model 2
HR95% CIPHR95% CIP
   Log Plasma leptin (ng/mL)1.42(0.65, 3.10)0.381.14(0.50, 2.60)0.75
   Log Plasma adiponectin (ng/mL)1.01(0.49, 2.10)0.981.10(0.52, 2.33)0.80
BMI ≥ 25 - < 30 kg/m2 (n = 929)
Type 2 diabetes cases (n = 119)
  Continuous AdipokinesModel 1*Model 2
HR95% CIPHR95% CIP
   Log Plasma leptin (ng/mL)1.33(0.89, 2.01)0.171.00(0.65, 1.53)0.99
   Log Plasma adiponectin (ng/mL)0.63(0.46, 0.87)<.010.77(0.55, 1.08)0.13
BMI ≥ 30 kg/m2 (n = 1311)
Type 2 diabetes cases (n = 308)
  Continuous AdipokinesModel 1*Model 2
HR95% CIpHR95% CIP
   Log Plasma leptin (ng/mL)1.09(0.83, 1.42)0.550.88(0.66, 1.16)0.37
   Log Plasma adiponectin (ng/mL)0.54(0.44, 0.66)<.00010.69(0.56, 0.86)<.001
  1. *Model 1: Adjusted for sex, age, waist circumference, systolic blood pressure, antihypertension medication, triglycerides, HDL-cholesterol, antihyperlipidemic medication, smoking, alcohol consumption, physical activity, and education level
  2. †Model 2: Adjusted for model 1 variables and HOMA-IR