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Table 3 Prospective associations (hazard ratios) between leptin and adiponectin with incident type 2 diabetes stratified by BMI groups

From: Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study

BMI < 25 kg/m2 (n = 416)

 Type 2 diabetes cases (n = 28)

  Continuous Adipokines

Model 1*

Model 2†

HR

95% CI

P

HR

95% CI

P

   Log Plasma leptin (ng/mL)

1.42

(0.65, 3.10)

0.38

1.14

(0.50, 2.60)

0.75

   Log Plasma adiponectin (ng/mL)

1.01

(0.49, 2.10)

0.98

1.10

(0.52, 2.33)

0.80

BMI ≥ 25 - < 30 kg/m2 (n = 929)

 Type 2 diabetes cases (n = 119)

  Continuous Adipokines

Model 1*

Model 2†

HR

95% CI

P

HR

95% CI

P

   Log Plasma leptin (ng/mL)

1.33

(0.89, 2.01)

0.17

1.00

(0.65, 1.53)

0.99

   Log Plasma adiponectin (ng/mL)

0.63

(0.46, 0.87)

<.01

0.77

(0.55, 1.08)

0.13

BMI ≥ 30 kg/m2 (n = 1311)

 Type 2 diabetes cases (n = 308)

  Continuous Adipokines

Model 1*

Model 2†

HR

95% CI

p

HR

95% CI

P

   Log Plasma leptin (ng/mL)

1.09

(0.83, 1.42)

0.55

0.88

(0.66, 1.16)

0.37

   Log Plasma adiponectin (ng/mL)

0.54

(0.44, 0.66)

<.0001

0.69

(0.56, 0.86)

<.001

  1. *Model 1: Adjusted for sex, age, waist circumference, systolic blood pressure, antihypertension medication, triglycerides, HDL-cholesterol, antihyperlipidemic medication, smoking, alcohol consumption, physical activity, and education level
  2. †Model 2: Adjusted for model 1 variables and HOMA-IR