Table 3 Cox regressions analysis for independent factors associated with SPK transplant outcomes
Variables | Reference | Levels | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|---|
HR (95%CI) | p-value | HR (95%CI) | p-value | |||
Patient death | ||||||
 Diabetes | T1DM | T2DM | 1.35 (0.23–6.01) | 0.70 |  |  |
 Recipient age | < 45 years | > 45 years | 3.2 (1.1–8.7) | 0.02 | 2.4 (0.9–6.1) | 0.07 |
 Recipient Gender | Male | Female | 0.5 (0.15–1.37) | 0.16 |  |  |
 Coronary heart disease | No | Yes | 3.15 (1.06–9.38) | 0.04 |  |  |
 Arterial obstructive disease | No | Yes | 3.26 (1.1–9.99) | 0.04 |  |  |
 Pretransplant dialysis | Pre-emptive | > 1 year | 2.9 (1.2–7.2) | < 0.01 | 4.5 (1.5–15.2) | 0.01 |
 Donor age | < 45 years | > 45 years | 2.3 (0.8–6.1) | 0.02 | 1.3 (1.1–5.1) | 0.04 |
 BMI recipient | < 25 | > 25 | 2.23 (0.67–7.5) | 0.19 |  |  |
 Donor COD | No CVD | CVD | 1.1 (0.3–2.7) | 0.98 |  |  |
 Calcineurininhibitor | CNI | Tacrolimus | 0.41 (0.5–3.2) | 0.38 |  |  |
 Donor gender | Male | Female | 3.98 (0.88–17.92) | 0.07 |  |  |
 Donor BMI | < 25 kg/m2 | > 25 kg/m2 | 2.29 (0.68–7.77) | 0.18 |  |  |
Pancreas Graft Loss | ||||||
 Diabetes | T1DM | T2DM | 1.34 (0.6–2.6) | 0.46 |  |  |
 Recipient age | < 45 years | > 45 years | 5.38 (1.99–14.51) | < 0.01 | 3.89 (1.40–10.78) | 0.01 |
 Coronary heart disease | No | Yes | 1.21 (0.50–2.94) | 0.68 |  |  |
 Arterial obstructive Disease | No | Yes | 1.48 (0.51–3.72) | 0.44 |  |  |
 Pretransplant dialysis | Pre-emptive | > 1 year | 1.19 (0.42–3.44) | 0.74 |  |  |
 Donor age | < 45 years | > 45 years | 2.69 (0.80–9.1) | 0.11 |  |  |
 Recipient BMI | < 25 | > 25 | 4.24 (1.57–11.43) | < 0.01 | 3.40 (1.21–9.59) | 0.02 |
 CIT Pancreas | < 12 h | > 12 h | 2.62 (1.13–6.07) | 0.03 | 3.25 (1.25–8.45) | 0.02 |
 HLA-Mismatch | 0 | 5 to 6 | 1.1 (1.0–3.2) | < 0.01 | 1.3 (1.1–5.2) | < 0.01 |
 Infectious complications | No | Yes | 1.3 (0.4–3.9) | 0.06 |  |  |
 Surgical complications | No | Yes | 5.9 (1.8–19.4) | < 0.01 | 4.8 (2.3–11.6) | < 0.01 |
 Recipient gender | Male | Female | 0.55 (0.24–1.24) | 0.15 |  |  |
 Donor gender | Male | Female | 1.36 (0.58–3.22) | 0.48 |  |  |
 Induction Therapy | None | ATG | 0.6 (0.3–1.5) | 0.38 |  |  |
 Donor BMI | < 25 | > 25 | 4.89 (2.1–11.45) | < 0.01 | 3.59 (1.45–8.92) | 0.01 |
Kidney Graft Loss | ||||||
 Diabetes | T1DM | T2DM | 1.1 (0.3–3.1)) | 0.95 |  |  |
 Recipient age | < 45 years | > 45 years | 1.2 (0.5–2.8) | 0.62 |  |  |
 Coronary heart disease | No | Yes | 2.1 (0.3–1.6) | 0.19 |  |  |
 Arterial obstructive disease | No | Yes | 2.2 (0.6–5.6) | 0.19 |  |  |
 Pretransplant dialysis | Pre-emptive | > 1 year | 1.1 (0.3–1.9) | < 0.01 | 1.2 (1.1–1.6) | < 0.01 |
 Donor age | < 45 years | > 45 years | 1.8 (0.8–6.8) | 0.02 | 2.3 (0.5–7.2) | 0.05 |
 BMI Recipient | < 25 | > 25 | 1.3 (0.4–2.9) | 0.70 |  |  |
 HLA Mismatch | 0 | 5to6 | 1.2 (1.0–3.2) | < 0.01 | 1.4 (1.2–6.2) | < 0.01 |
 CIT Kidney | < 11 h | > 11 h | 1.7 (0.8–3.66) | 0.16 |  |  |
 Recipient gender | Male | Female | 0.72 (0.3–1.4) | 0.43 |  |  |
 Infectious complications | No | Yes | 1.4 (0.6–3.4) | 0.39 |  |  |
 Rejection | No | Yes | 1.3 (0.6–2.7) | 0.47 |  |  |
 Donor BMI | < 25 | > 25 | 0.91 (0.3–2.4) | 0.85 |  |  |
 Donor COD | Others | CVD | 1.1 (0.5–2.5) | 0.80 |  |  |
 DGF Kidney | No | Yes | 1.8 (0.6–5.2) | 0.26 |  |  |
 Surgical complications | No | Yes | 1.9 (0.7–2.1) | 0.08 |  |  |
 Induction Therapy | None | ATG | 1.1 (0.5–2.5) | 0.80 |  |  |