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Table 3 Cox regressions analysis for independent factors associated with SPK transplant outcomes

From: Short and long-term metabolic outcomes in patients with type 1 and type 2 diabetes receiving a simultaneous pancreas kidney allograft

VariablesReferenceLevelsUnivariate AnalysisMultivariate Analysis
HR (95%CI)p-valueHR (95%CI)p-value
Patient death
 DiabetesT1DMT2DM1.35 (0.23–6.01)0.70  
 Recipient age< 45 years> 45 years3.2 (1.1–8.7)0.022.4 (0.9–6.1)0.07
 Recipient GenderMaleFemale0.5 (0.15–1.37)0.16  
 Coronary heart diseaseNoYes3.15 (1.06–9.38)0.04  
 Arterial obstructive diseaseNoYes3.26 (1.1–9.99)0.04  
 Pretransplant dialysisPre-emptive> 1 year2.9 (1.2–7.2)< 0.014.5 (1.5–15.2)0.01
 Donor age< 45 years> 45 years2.3 (0.8–6.1)0.021.3 (1.1–5.1)0.04
 BMI recipient< 25> 252.23 (0.67–7.5)0.19  
 Donor CODNo CVDCVD1.1 (0.3–2.7)0.98  
 CalcineurininhibitorCNITacrolimus0.41 (0.5–3.2)0.38  
 Donor genderMaleFemale3.98 (0.88–17.92)0.07  
 Donor BMI< 25 kg/m2> 25 kg/m22.29 (0.68–7.77)0.18  
Pancreas Graft Loss
 DiabetesT1DMT2DM1.34 (0.6–2.6)0.46  
 Recipient age< 45 years> 45 years5.38 (1.99–14.51)< 0.013.89 (1.40–10.78)0.01
 Coronary heart diseaseNoYes1.21 (0.50–2.94)0.68  
 Arterial obstructive DiseaseNoYes1.48 (0.51–3.72)0.44  
 Pretransplant dialysisPre-emptive> 1 year1.19 (0.42–3.44)0.74  
 Donor age< 45 years> 45 years2.69 (0.80–9.1)0.11  
 Recipient BMI< 25> 254.24 (1.57–11.43)< 0.013.40 (1.21–9.59)0.02
 CIT Pancreas< 12 h> 12 h2.62 (1.13–6.07)0.033.25 (1.25–8.45)0.02
 HLA-Mismatch05 to 61.1 (1.0–3.2)< 0.011.3 (1.1–5.2)< 0.01
 Infectious complicationsNoYes1.3 (0.4–3.9)0.06  
 Surgical complicationsNoYes5.9 (1.8–19.4)< 0.014.8 (2.3–11.6)< 0.01
 Recipient genderMaleFemale0.55 (0.24–1.24)0.15  
 Donor genderMaleFemale1.36 (0.58–3.22)0.48  
 Induction TherapyNoneATG0.6 (0.3–1.5)0.38  
 Donor BMI< 25> 254.89 (2.1–11.45)< 0.013.59 (1.45–8.92)0.01
Kidney Graft Loss
 DiabetesT1DMT2DM1.1 (0.3–3.1))0.95  
 Recipient age< 45 years> 45 years1.2 (0.5–2.8)0.62  
 Coronary heart diseaseNoYes2.1 (0.3–1.6)0.19  
 Arterial obstructive diseaseNoYes2.2 (0.6–5.6)0.19  
 Pretransplant dialysisPre-emptive> 1 year1.1 (0.3–1.9)< 0.011.2 (1.1–1.6)< 0.01
 Donor age< 45 years> 45 years1.8 (0.8–6.8)0.022.3 (0.5–7.2)0.05
 BMI Recipient< 25> 251.3 (0.4–2.9)0.70  
 HLA Mismatch05to61.2 (1.0–3.2)< 0.011.4 (1.2–6.2)< 0.01
 CIT Kidney< 11 h> 11 h1.7 (0.8–3.66)0.16  
 Recipient genderMaleFemale0.72 (0.3–1.4)0.43  
 Infectious complicationsNoYes1.4 (0.6–3.4)0.39  
 RejectionNoYes1.3 (0.6–2.7)0.47  
 Donor BMI< 25> 250.91 (0.3–2.4)0.85  
 Donor CODOthersCVD1.1 (0.5–2.5)0.80  
 DGF KidneyNoYes1.8 (0.6–5.2)0.26  
 Surgical complicationsNoYes1.9 (0.7–2.1)0.08  
 Induction TherapyNoneATG1.1 (0.5–2.5)0.80