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Table 3 Blood steroid profiles of patients with PA or PASCS

From: Clinical characterization of patients with primary aldosteronism plus subclinical Cushing’s syndrome

 PA (n = 45)PASCS (n = 14)PA vs. PASCS
Mean ± SD
Median [IQR]
Mean ± SD
Median [IQR]
P value
PAC, pg/mL208.0 [273.0–159.8]255.0 [713.3–153.5]<  0.005
PRA, ng/mL/h0.2 [0.3–0.1]0.15 [0.3–0.1]NS
PAC/PRA ratio1258.3 [1956.3–643.1]1450.0 [5010.0–529.4]<  0.005
PRA in the furosemide upright posture challenge test, ng/mL/h0.4 [0.7–0.2]0.2 [0.8–0.15]NS
PAC in the saline infusion test, pg/mL160.0 ± 166.5313.5 ± 364.8NS
PAC/PRA ratio in the captopril challenge test730.7 ± 745.73028.5 ± 3648.9<  0.001
PAC in the captopril challenge test, pg/mL149.0 ± 94.2348.6 ± 340.1<  0.005
Cortisol, μg/dL12.4 ± 4.316.4 ± 6.6<  0.05
ACTH, pg/mL23.1 ± 13.618.2 ± 18.8NS
DHEAS, μg/dL111.5 ± 75.178.5 ± 129.8NS
ACTH in the CRH challenge test, pg/mL57.1 ± 10.818.9 ± 8.9<  0.005
  1. Values are expressed as mean ± SD in the upper row or median [IQR] in the lower row
  2. PA primary aldosteronism, PASCS primary aldosteronism plus subclinical Cushing’s syndrome, SD standard deviation, IQR interquartile range, PAC plasma aldosterone concentration, PRA plasma renin activity, NS not significant, ACTH adrenocorticotropic hormone, DHEAS dehydroepiandrosterone sulfate, CRH corticotropin-releasing hormone