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Table 3 Univariable and multivariable logistic regression analyses for the composite primary outcome (CVD or death) at a median of 3.7 years’ follow-up

From: Skin autofluorescence predicts new cardiovascular disease and mortality in people with type 2 diabetes

Analysis n OR 95% CI P-value
Univariable
 SAF (AU) 2349 2.59 2.10–3.20 1.3 × 10−18
 Age (years) 2349 1.06 1.05–1.08 4.4 × 10−25
 Male sex (y/n) 2349 1.49 1.17–1.90 0.001
 BMI (kg/m2) 2349 1.00 0.97–1.02 0.697
 Waist circumference (cm) 2347 1.01 1.00–1.02 0.025
 Glucose (mmol/l) 2333 0.99 0.94–1.05 0.859
 HbA1c (mmol/mol) 2334 1.01 1.00–1.02 0.092
 SBP (mmHg) 2343 1.00 0.99–1.00 0.138
 DBP (mmHg) 2343 0.97 0.96–0.99 5.2 × 10−5
 HR (/min) 2343 0.99 0.98–1.00 0.013
 Cholesterol (mmol/l) 2341 0.91 0.82–1.01 0.070
 Triacylglycerol (mmol/l) 2341 0.99 0.89–1.09 0.781
 eGFR (ml/min/1.73m2) 2342 0.97 0.97–0.98 6.0 × 10−14
 Former smoking (y/n) 2335 1.30 1.02–1.64 0.033
 Current smoking (y/n) 2335 1.19 0.89–1.60 0.246
 Statin (y/n) 2349 1.44 1.14–1.83 0.002
 BP-lowering therapy (y/n) 2349 2.28 1.77–2.94 1.7 × 10−10
 Baseline CVD (y/n) 2349 6.67 5.04–8.83 2.8 × 10−40
Multivariable model 1 2310    
 SAF (AU)   1.41 1.10–1.82 0.008
 Age (years)   1.05 1.03–1.07 5.9 × 10−8
 Male sex (y/n)   1.16 0.84–1.62 0.368
 BMI (kg/m2)   0.96 0.90–1.01 0.126
 Waist (cm)   1.02 1.00–1.05 0.031
 Glucose (mmol/l)   0.99 0.90–1.08 0.784
 HbA1c (mmol/mol)   1.01 1.00–1.03 0.124
 SBP (mmHg)   0.99 0.98–1.00 0.051
 DBP (mmHg)   0.99 0.97–1.01 0.411
 HR (/min)   1.01 1.00–1.02 0.081
 Cholesterol (mmol/l)   1.08 0.93–1.25 0.331
 Triacylglycerol (mmol/l)   1.01 0.89–1.15 0.848
 eGFR (ml/min/1.73m2)   1.00 0.99–1.01 0.845
 Former smoking (y/n)   0.95 0.69–1.30 0.738
 Current smoking (y/n)   1.69 1.13–2.53 0.010
 Statin (y/n)   0.72 0.51–1.01 0.054
 BP-lowering therapy (y/n)   1.33 0.97–1.82 0.075
 Baseline CVD (y/n)   5.25 3.71–7.42 7.4 × 10−21
Multivariable model 2 2327    
 SAF (AU)   1.48 1.15–1.90 0.002
 Age (years)   1.06 1.04–1.07 8.2 × 10−14
 Waist (cm)   1.02 1.00–1.02 0.005
 SBP (mmHg)   0.99 0.98–1.00 0.003
 Current smoking (y/n)   1.83 1.31–2.56 4.4 × 10−4
 Statin (y/n)   0.70 0.53–0.94 0.016
 Baseline CVD (y/n)   5.30 3.84–7.33 4.8 × 10−24
  1. Baseline risk factors were used to predict the median 3.7 year risk of the composite outcome of new CVD events and death
  2. SAF, age, glucose, HbA1c, waist circumference, systolic and diastolic BP, HR, cholesterol, triacylglycerol and eGFR were defined as continuous variables. Male sex, current smoking, statin use, use of BP-lowering therapy and baseline CVD were defined as categorical variables
  3. DBP, diastolic BP; SBP, systolic BP; HR, heart rate; y/n, yes/no