Table 3 Univariable and multivariable logistic regression analyses for the composite primary outcome (CVD or death) at a median of 3.7 years’ follow-up
Analysis | n | OR | 95% CI | P-value |
|---|---|---|---|---|
Univariable | ||||
 SAF (AU) | 2349 | 2.59 | 2.10–3.20 | 1.3 × 10−18 |
 Age (years) | 2349 | 1.06 | 1.05–1.08 | 4.4 × 10−25 |
 Male sex (y/n) | 2349 | 1.49 | 1.17–1.90 | 0.001 |
 BMI (kg/m2) | 2349 | 1.00 | 0.97–1.02 | 0.697 |
 Waist circumference (cm) | 2347 | 1.01 | 1.00–1.02 | 0.025 |
 Glucose (mmol/l) | 2333 | 0.99 | 0.94–1.05 | 0.859 |
 HbA1c (mmol/mol) | 2334 | 1.01 | 1.00–1.02 | 0.092 |
 SBP (mmHg) | 2343 | 1.00 | 0.99–1.00 | 0.138 |
 DBP (mmHg) | 2343 | 0.97 | 0.96–0.99 | 5.2 × 10−5 |
 HR (/min) | 2343 | 0.99 | 0.98–1.00 | 0.013 |
 Cholesterol (mmol/l) | 2341 | 0.91 | 0.82–1.01 | 0.070 |
 Triacylglycerol (mmol/l) | 2341 | 0.99 | 0.89–1.09 | 0.781 |
 eGFR (ml/min/1.73m2) | 2342 | 0.97 | 0.97–0.98 | 6.0 × 10−14 |
 Former smoking (y/n) | 2335 | 1.30 | 1.02–1.64 | 0.033 |
 Current smoking (y/n) | 2335 | 1.19 | 0.89–1.60 | 0.246 |
 Statin (y/n) | 2349 | 1.44 | 1.14–1.83 | 0.002 |
 BP-lowering therapy (y/n) | 2349 | 2.28 | 1.77–2.94 | 1.7 × 10−10 |
 Baseline CVD (y/n) | 2349 | 6.67 | 5.04–8.83 | 2.8 × 10−40 |
Multivariable model 1 | 2310 | Â | Â | Â |
 SAF (AU) |  | 1.41 | 1.10–1.82 | 0.008 |
 Age (years) |  | 1.05 | 1.03–1.07 | 5.9 × 10−8 |
 Male sex (y/n) |  | 1.16 | 0.84–1.62 | 0.368 |
 BMI (kg/m2) |  | 0.96 | 0.90–1.01 | 0.126 |
 Waist (cm) |  | 1.02 | 1.00–1.05 | 0.031 |
 Glucose (mmol/l) |  | 0.99 | 0.90–1.08 | 0.784 |
 HbA1c (mmol/mol) |  | 1.01 | 1.00–1.03 | 0.124 |
 SBP (mmHg) |  | 0.99 | 0.98–1.00 | 0.051 |
 DBP (mmHg) |  | 0.99 | 0.97–1.01 | 0.411 |
 HR (/min) |  | 1.01 | 1.00–1.02 | 0.081 |
 Cholesterol (mmol/l) |  | 1.08 | 0.93–1.25 | 0.331 |
 Triacylglycerol (mmol/l) |  | 1.01 | 0.89–1.15 | 0.848 |
 eGFR (ml/min/1.73m2) |  | 1.00 | 0.99–1.01 | 0.845 |
 Former smoking (y/n) |  | 0.95 | 0.69–1.30 | 0.738 |
 Current smoking (y/n) |  | 1.69 | 1.13–2.53 | 0.010 |
 Statin (y/n) |  | 0.72 | 0.51–1.01 | 0.054 |
 BP-lowering therapy (y/n) |  | 1.33 | 0.97–1.82 | 0.075 |
 Baseline CVD (y/n) |  | 5.25 | 3.71–7.42 | 7.4 × 10−21 |
Multivariable model 2 | 2327 | Â | Â | Â |
 SAF (AU) |  | 1.48 | 1.15–1.90 | 0.002 |
 Age (years) |  | 1.06 | 1.04–1.07 | 8.2 × 10−14 |
 Waist (cm) |  | 1.02 | 1.00–1.02 | 0.005 |
 SBP (mmHg) |  | 0.99 | 0.98–1.00 | 0.003 |
 Current smoking (y/n) |  | 1.83 | 1.31–2.56 | 4.4 × 10−4 |
 Statin (y/n) |  | 0.70 | 0.53–0.94 | 0.016 |
 Baseline CVD (y/n) |  | 5.30 | 3.84–7.33 | 4.8 × 10−24 |