Association between decreased thyroid stimulating hormone and hyperuricemia in type 2 diabetic patients with early-stage diabetic kidney disease

Table 2 Multiple regression of TSH associated with SUA in type 2 diabetic patients with early-stage DKD

Parameters	β	SE	95% CI	Standardized β	P
Model 1^a	−39.52	4.99	−47.35 ~ − 27.69	−7.52	< 0.001
Model 2^b	−34.91	5.06	−44.86 ~ − 24.95	−0.40	< 0.001
Model 3^c	−25.69	3.90	−33.38 ~ − 18.00	−0.29	< 0.001

Abbreviations: SE Standard error, CI Confidence interval, TSH Thyroid stimulating hormone, SUA Serum uric acid, DKD Diabetic kidney disease
The results were based on hierarchical multivariate linear regression taking TSH as a continuous variable in the models (n = 254). ^aModel 1: unadjusted model; ^bModel 2: basic adjusting model, adjusted for age and gender; ^cModel 3: fully adjusted model, additionally adjusting for body mass index (BMI), systolic blood pressure (SBP), triglycerides (TG), fasting blood glucose (FBG), fasting insulin (FINS), estimated glomerular filtration rate (eGFR), and urinary albumin-to-creatinine ratio (UACR)

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