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Table 3 The number of users of thyroid hormones dispensed 1 year before and after the first dispense of LDN. The groups are stratified based on the number of LDN dispenses: LDN × 1 (N = 260), LDN × 2–3 (N = 198) and LDN × 4+ (N = 440). LDN: Low dose naltrexone

From: No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study

  Number of users Difference
Before After  
N % N % % points 95%CI p
Levothyroxine (LT4)
 LDN ×  1 243 (93.5) 240 (92.3) −1.2 (−3.7 to 1.3) 0.366
 LDN ×  2–3 191 (96.5) 187 (94.4) −2.0 (−4.0 to −0.1) 0.045
 LDN × 4+ 420 (95.5) 420 (95.5) 0.0 (−1.5 to 1.5) 1.000
Triiodothyronine (T3)
 LDN × 1 28 (10.8) 24 (9.2) −1.5 (−4.1 to 1.1) 0.248
 LDN × 2–3 15 (7.6) 11 (5.6) −2.0 (−5.1 to 1.1) 0.206
 LDN × 4+ 51 (11.6) 55 (12.5) 0.9 (−1.2 to 3.0) 0.394