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Table 2 Average cumulative number of DDDs of thyroid hormones dispensed to patients 1 year before and after the first dispense of LDN. Patients stratified based on the number of LDN dispenses: LDN × 1 (N = 260), LDN × 2–3 (N = 198) and LDN × 4+ (N = 440). LDN: Low dose naltrexone. DDD: Defined daily dose

From: No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study

 

Dispensed drugs (DDD)

Difference (DDD)

 

Before

After

Mean

95% CI difference

p

Levothyroxine (LT4)

 LDN × 1

225.4

223.1

−2.3

(−15.9 to 11.2)

0.737

 LDN × 2–3

245.9

248.9

3.0

(−15.6 to 21.5)

0.754

 LDN × 4+

239.0

242.9

3.9

(−7.1 to 14.9)

0.490

Triiodothyronine (T3)

 LDN × 1

10.4

10.5

0.1

(−2.8 to 3.1)

0.932

 LDN × 2–3

8.1

5.9

−2.2

(−5.1 to 0.7)

0.139

 LDN × 4+

11.4

11.1

−0.3

(−2.9 to 2.3)

0.818