Skip to main content

Table 2 Average cumulative number of DDDs of thyroid hormones dispensed to patients 1 year before and after the first dispense of LDN. Patients stratified based on the number of LDN dispenses: LDN × 1 (N = 260), LDN × 2–3 (N = 198) and LDN × 4+ (N = 440). LDN: Low dose naltrexone. DDD: Defined daily dose

From: No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study

  Dispensed drugs (DDD) Difference (DDD)  
Before After Mean 95% CI difference p
Levothyroxine (LT4)
 LDN × 1 225.4 223.1 −2.3 (−15.9 to 11.2) 0.737
 LDN × 2–3 245.9 248.9 3.0 (−15.6 to 21.5) 0.754
 LDN × 4+ 239.0 242.9 3.9 (−7.1 to 14.9) 0.490
Triiodothyronine (T3)
 LDN × 1 10.4 10.5 0.1 (−2.8 to 3.1) 0.932
 LDN × 2–3 8.1 5.9 −2.2 (−5.1 to 0.7) 0.139
 LDN × 4+ 11.4 11.1 −0.3 (−2.9 to 2.3) 0.818