Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children

Mohany, Khalid M.; Al rugaie, Osamah; Al-wutayd, Osama; Al-Nafeesah, Abdullah; Saleem, Tahia H.

doi:10.1186/s12902-020-00628-y

Table 2 Correlation of circulating microRNAs relative expressions and serum betatrophin levels with the other studied parameters in the three groups

From: Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children

			BMI percentile	Cholesterol (mg/dL)	Glucose (mg/dL)	HDLc (mg/dL)	LDLc (mg/L)	HbA1c (%)	TAG (mg/dL)	Insulin (μg/mL)	C-Peptide (ng/mL)
G1 (healthy, n = 50)	miR-486R	r	0.282^*	0.205	0.323^*	0.078	0.167	0.271	0.190	−0.293^*	− 0.176
	miR-486R	p	0.048	0.154	0.022	0.590	0.247	0.057	0.186	0.039	0.223
	miR-146bR	r	−0.056	−0.014	0.049	0.126	−0.043	−0.171	0.075	−0.135	− 0.156
	miR-146bR	p	0.701	0.921	0.736	0.383	0.765	0.235	0.604	0.351	0.279
	miR-15bR	r	0.254	0.088	0.130	0.104	0.067	0.377^**	0.073	−0.450^**	−0.235
	miR-15bR	p	0.075	0.546	0.368	0.472	0.645	0.007	0.616	0.001	0.100
	Betatrophin (ng/mL)	r	0.335^*	−0.087	0.339^*	− 0.196	− 0.013	0.316**	− 0.275	0.064	0.053
	Betatrophin (ng/mL)	p	0.017	0.548	0.016	0.172	0.930	0.049	0.063	0.661	0.713
G2 (obese, n = 35)	miR-486R	r	0.335^*	0.073	0.691^**	−0.510^**	0.238	0.785^**	−0.022	− 0.554^**	− 0.424^*
	miR-486R	p	0.049	0.675	0.000	0.002	0.168	0.000	0.902	0.001	0.011
	miR-146bR	r	0.673*	−0.288	0.397^*	−0.362^*	− 0.154	0.493^**	− 0.205	− 0.314**	− 0.332*
	miR-146bR	p	0.000	0.094	0.018	0.033	0.378	0.003	0.237	0.046	0.041
	miR-15bR	r	0.454*	−0.291	0.483^**	−0.359^*	− 0.152	0.551^**	− 0.249	− 0.359^*	− 0.344^*
	miR-15bR	p	0.018	0.090	0.003	0.034	0.383	0.001	0.150	0.034	0.043
	Betatrophin (ng/mL)	r	0.376^*	−0.293	0.392^*	−0.242	− 0.206	0.363*	− 0.146	− 0.237	−0.124
	Betatrophin (ng/mL)	p	0.026	0.087	0.020	0.161	0.236	0.041	0.403	0.171	0.579
G3 (obese with T2DM, n = 35)	miR-486R	r	0.446^**	0.086	0.564^**	0.125	0.032	0.561^**	0.785^**	−0.371*	− 0.765^**
	miR-486R	p	0.007	0.621	0.000	0.473	0.855	0.000	0.000	0.021	0.000
	miR-146bR	r	0.588^**	−0.077	0.495^**	0.067	−0.127	0.395^*	0.421^*	−0.427**	− 0.502^**
	miR-146bR	p	0.000	0.661	0.003	0.703	0.466	0.019	0.012	0.012	0.002
	miR-15bR	r	0.388^*	−0.019	0.824^**	0.218	−0.102	0.669^**	0.283	−0.583^**	−0.355^*
	miR-15bR	p	0.021	0.912	0.000	0.209	0.558	0.000	0.099	0.000	0.036
	Betatrophin (ng/mL)	r	0.461^**	0.077	0.601^**	0.116	0.043	0.428*	0.458^**	−0.410*	− 0.425^*
	Betatrophin (ng/mL)	p	0.005	0.660	0.000	0.506	0.807	0.032	0.006	0.013	0.011

**Correlation is significant at the 0.01 level (2-tailed)
*Correlation is significant at the 0.05 level (2-tailed)
T2DM type 2 diabetes mellitus, BMI body mass index, HDLc high density lipoprotein cholesterol, LDLc low density lipoprotein cholesterol, HbA1c glycated hemoglobin, TAC triacylglycerol, microR-486R microRNA 486 relative expression, miR-146bR microRNA 146b relative expression, miR-15bR microRNA 15b relative expression.

Back to article page

ISSN: 1472-6823

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Endocrine Disorders

Contact us