Table 1 Comparison of different studied variables (mean ± SD) among G1, G2 and G3
G1 (healthy, n = 50) | G2 (obese, n = 35) | G3 (obese with T2DM, n = 35) | p-Value | ||||
|---|---|---|---|---|---|---|---|
G1Vs G2 Vs G3 | G2 Vs G1 | G3 Vs G1 | G3 Vs G2 | ||||
Age (years) | 9.31 ± 1.47 | 9 ± 1.77 | 9.59 ± 1.40 | 0.273 | 0.38 | 0.36 | 0.12 |
Gender | |||||||
• Male | 31 (62%) | 27 (77%) | 22 (63%) | 0.294 | 0.16 | 0.78 | 0.29 |
• Female | 19 (38%) | 8 (23%) | 13 (37%) | ||||
BMI percentile | 81.0 ± 1.2 | 96.8 ± 1.6 | 96.7 ± 1.4 | < 0.001 | < 0.001 | < 0.001 | 0.935 |
Glucose (mg/dL) | 96.46 ± 8.78 | 101 ± 15.40 | 116.65 ± 18.76 | 0.006 | 0.08 | 0.004 | 0.04 |
Insulin (μg/mL) | 10.16 ± 1.48 | 10.50 ± 0.69 | 11.20 ± 0.93 | 0.037 | 0.20 | 0.002 | 0.014 |
C-Peptide (ng/mL) | 2.98 ± 0.43 | 3.13 ± 0.21 | 3.21 ± 0.28 | 0.007 | 0.02 | 0.008 | 0.09 |
HbA1c (%) | 4.17 ± 0.21 | 4.85 ± 0.99 | 7.32 ± 2.62 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Cholesterol (mg/dL) | 188.79 ± 21.26 | 190.14 ± 26.75 | 196.45 ± 26.49 | 0.34 | 0.79 | 0.14 | 0.32 |
HDLc (mg/dL) | 39.30 ± 1.82 | 36.91 ± 8.12 | 35.61 ± 10.40 | 0.06 | 0.09 | 0.04 | 0.55 |
LDLc (mg/dL) | 127.43 ± 20.12 | 131.39 ± 25.95 | 135.72 ± 22.23 | 0.252 | 0.43 | 0.08 | 0.45 |
TAG (mg/dL) | 110.32 ± 22.43 | 111.17 ± 18.56 | 125.61 ± 20.65 | 0.001 | 0.80 | 0.002 | 0.001 |
miR-486R | 1.52 ± 0.38 | 2.11 ± 0.25 | 2.71 ± 0.29 | 0.002 | 0.003 | < 0.001 | 0.001 |
miR-146bR | 2.42 ± 0.58 | 3.01 ± 0.18 | 3.54 ± 0.24 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
miR-15bR | 3.82 ± 0.56 | 4.32 ± 0.27 | 5.10 ± 0.36 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |
Betatrophin (ng/mL) | 47.17 ± 6.85 | 54.54 ± 17.67 | 71.68 ± 29.63 | < 0.001 | < 0.001 | < 0.001 | < 0.001 |