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Table 2 Associations of GDM, thyroid disorders, and interaction between GDM and thyroid disorders on development of T2DM using a pooled logistic analysis

From: Assessment of the simultaneous effect of hypothyroidism and thyroid autoimmunity with gestational diabetes on the incidence of type 2 diabetes

Variables

Unadjusted model

Model 1

Model 2

Model 3

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

Thyroid disorder

1.14 (0.82, 1.58)

0.44

1.13 (0.81, 1.57)

0.46

1.08 (0.77, 1.51)

0.64

1.24 (0.87, 1.75)

0.22

GDM

1.54 (1.06, 2.25)

0.02

1.67 (1.14, 2.45)

0.01

1.40 (0.94, 2.07)

0.09

1.42 (0.95, 2.12)

0.08

GDM × Thyroid disorder

1.27 (0.66, 2.43)

0.47

1.32 (0.69, 2.54)

0.40

1.16 (0.58, 2.31)

0.67

1.41 (0.71, 2.80)

0.33

  1. Model 1: adjusted for age
  2. Model 2: adjusted for age, BMI, educational status, smoking and family history of DM
  3. Model 3: adjusted for serum triglycerides, serum total-cholesterol, serum HDL-cholesterol, systolic blood pressure, diastolic blood pressure, and fasting plasma glucose
  4. Thyroid disorders: Clinical, subclinical hypothyroidism, and thyroid autoimmunity, GDM: gestational diabetes, T2DM: type 2 diabetes mellitus,
  5. OR odds ratio, CI confidence interval
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BMC Endocrine Disorders

ISSN: 1472-6823

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