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Table 3 Stratification of hormonal, antropometric, clinical, radiologic, biochemical and metabolic parameters in ACS patients by age

From: The prevalence and characteristics of non-functioning and autonomous cortisol secreting adrenal incidentaloma after patients’ stratification by body mass index and age

Variable Age (years) P value
< 40
N = 3
40–49
N = 11
50–59
N = 40
60–69
N = 37
70–79
N = 36
> 79
N = 15
Basal serum cortisol (nmol/l) b 339 (239-) 372 (320.5–565.5) 444 (362.5–510.5) 478.5 (372–606.5) 475 (451–604) 0.123
Serum cortisol after ODST (nmol/l)a 56 (54.1-) 62.3 (52–92.7) 70.25 (57.45–93.18) 67.9 (54.95–94.35) 62.95 (56.8–84.28) 67 (52.4–76.4) 0.774
Basal DHEAS (μmol/L) b 1.85 (0.5–3) 0.9 (0.43–1.8) 0.9 (0.5–1) 0.44 (0.38–1.03) 0.9 (0.4–1.68) 0.445
DHEAS after ODST (μmol/L) b 0.8 (0.2–1.2) 0.5 (0.3–1.1) 0.5 (0.3–0.85) 0.5 (0.2–0.7) 1 (0.25–1.8) 0.716
Aldosteron (nmol/l) b 0.31 (0.13–0.62) 0.2 (0.11–0.28) 0.21 (0.14–0.42) 0.21 (0.07–0.35) 0.23 (0.14–0.27) 0.870
Plasma Renin Activity – PRA (μg/l/h) b 0.21 (0.06–2.69) 0.49 (0.15–1.06) 0.68 (0.34–2.98) 0.94 (0.34–2.32) 0.61 (0.18–1.97) 0.719
TSH (mE/l) 4.51 (2.4-) 0.39 (0.34–1.31) 1.37 (0.71–2.36) 6.15 (5.73–7.48) 0.8 (0.48–5.85) 1.26 (0.51–3.15) 0.001
Pairwise comparisons
40–49 vs. 60–69 P = 0.002
50–59 vs. 60–69 P = 0.021
60–69 vs. 70–79 P = 0.025
Body mass (kg) 75 (74.6-) 67.3 (62.3–75) 83.1 (67.5–92.2) 73 (62.3–89.3) 76 (67.7–80.8) 70.15 (64.48–82.85) 0.061
BMI (kg/m2) 27.76 (25.81-) 25.27 (22.58–26.91) 28.91 (25.61–31.9) 29.34 (22.98–32.12) 27.59 (26.13–33.46) 28.55 (25.61–30.92) 0.227
Systolic blood pressure (mm Hg) 122 (119–122) 120 (115–140) 140.5 (125.75–150.75) 145 (112–150) 146.5 (131.25–164.5) 150 (135–160) 0.038
Diastolic blood pressure (mm Hg) 82 (76–82) 75 (75–90) 80 (75–90) 73 (68–85) 75 (70–80) 74 (65–82) 0.037
Heart rate 91 (51–91) 80.5 (70.25–94.5) 78 (65–84.75) 77 (67–84) 70 (66.25–84.5) 82 (71.75–90.5) 0.637
Fasting glucose (mmol/liter) 4.7 (4.6-) 4.6 (4.28–5.1) 5.15 (4.93–5.98) 5.5 (5.1–6.38) 5.4 (5–5.98) 6.15 (5.33–6.55) 0.003
Pairwise comparisons
40–49 vs. 60–69 P = 0.021
40–49 vs. > 79 P = 0.006
Total cholesterol (mmol/liter) 5.4 (5.3-) 5.05 (5-) 5.7 (4.7–6.5) 5 (4.1–5.9) 4.6 (4–5.2) 5 (3.6–5.3) 0.019
Pairwise comparisons
50–59 vs. 70–79 P = 0.014
HDL (mmol/liter) 1.3 (1-) 1.45 (1.3-) 1.2 (1–1.6) 1.3 (1.1–1.9) 1.2 (1.1–1.5) 1.05 (0.75–1.1) 0.125
LDL (mmol/liter) 3.6 (3.2-) 2.85 (2.7-) 3.6 (2.9–4.4) 3 (2.5–3.5) 2.7 (2.1–3) 2.7 (1.4–3.7) 0.021
Pairwise comparisons
50–59 vs. 70–79 P = 0.010
Triglycerides (mmol/liter) 2.7 (1.2-) 1.55 (1.1-) 1.6 (1–2) 1.6 (1.2–2) 1.7 (1.2–2.1) 1.9 (1.15–2.85) 0.660
Creatinine (mmol/liter) 69 (64-) 69 (59–74) 67.5 (60.5–74.75) 80 (71–90) 74 (67–92) 79.5 (68.5–96) 0.006
Pairwise comparisons
50–59 vs. 60–69 P = 0.023
Sodium (mmol/liter) 141 (137-) 141 (139–143) 142 (140–144) 142 (141–143) 142 (141–144) 141.5 (139.75–144) 0.630
  1. afor 70 patients, data were provided as below 27.6, for 20 below 28 and for 1 below 31.3
  2. bdata available for only 1 patient or no patients
  3. Data are given as Median (25–75%)