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Table 2 Stratification of hormonal, antropometric, clinical, radiologic, biochemical and metabolic parameters in NFAI patients by age

From: The prevalence and characteristics of non-functioning and autonomous cortisol secreting adrenal incidentaloma after patients’ stratification by body mass index and age

Variable Age (years) P value
< 40
N = 5
40–49
N = 36
50–59
N = 86
60–69
N = 86
70–79
N = 68
> 79
N = 9
Basal serum cortisol (nmol/l) a a 371 (312–439) 375 (323–458) 403 (324.5–457.25) 392 (317–430) 0.489
Serum cortisol after ODST (nmol/l)a 28 (27.6–28) 30.3 (27.6–38) 35.35 (30.9–39.28) 34.05 (28.78–43.28) 36.85 (29.28–41.33) 30.3 (27.6–38.95) 0.183
Basal DHEAS (μmol/L) a 2.15 (1.7–2.8) 1.7 (1.2–3.2) 1.55 (0.83–2.1) 1.3 (0.81–2.1) 1.15 (0.53–2.45) 0.002
DHEAS after ODST (μmol/L) a 0.65 (0.4–1.2) 0.9 (0.4–1.8) 0.69 (0.3–1.2) 0.6 (0.34–0.93) 1.15 (0.23–1.95) 0.041
Aldosteron (nmol/l) a 0.18 (0.15–0.2) 0.14 (0.1–0.23) 0.17 (0.11–0.26) 0.2 (0.11–0.26) 0.1 (0.06–0.26) 0.278
Plasma Renin Activity – PRA (μg/l/h) a 0.41 (0.23–0.89) 0.39 (0.15–1.28) 0.27 (0.11–1.5) 0.54 (0.26–1.87) 0.31 (0.01–0.31) 0.421
TSH (mE/l) 1.35 (1.27–1.35) 1.39 (1.19–3.04) 2.11 (1.24–3.26) 6.5 (5.6–7.63) 1.33 (0.83–4.92) 0.46 (0.21–0.79) < 0.001
Pairwise comparisons
50–59 vs. > 79 P = 0.005
60–69 vs. > 79 P < 0.001
60–69 vs. 70–79 P = 0.003
40–49 vs. 60–69 P = 0.007
50–59 vs. 60–69 P = 0.024
Body mass (kg) 92.45 (54.75–143.95) 75.3 (65.9–86) 83.5 (72.3–93.85) 78.5 (73.5–90) 80.45 (65.7–88.9) 71 (63.5–82) 0.031
BMI (kg/m2) 35.45 (20.46–52.53) 28.57 (24.13–31.2) 29.04 (25.77–32.54) 28.56 (25.8–33.35) 28.2 (24.98–31.23) 28.04 (25.59–30.53) 0.715
Systolic blood pressure (mm Hg) 120 (118.5–160) 127.5 (120–140) 135 (120–145) 141.5 (126.5–151.5) 145 (126–155) 155 (152–170) < 0.001
Pairwise comparisons
40–49 vs. > 79 P = 0.003
50–59 vs. > 79 P = 0.007
Diastolic blood pressure (mm Hg) 85 (80–97.5) 77 (73–86.25) 78 (70–87) 75 (70–83.5) 74 (65–80) 88 (80–98) 0.002
Pairwise comparisons
70–79 vs. > 79 P = 0.014
Heart rate 94 (69.5–100.5) 80 (71.5–90) 73.5 (68–90.25) 72.5 (63.25–81.75) 75 (67–87.75) 70 (66–87) 0.258
Fasting glucose (mmol/liter) 4.5 (4.4–5.2) 4.9 (4.6–5.5) 5.3 (5–6.2) 5.55 (5.03–6.2) 5.4 (5–6.2) 5.6 (5.05–6.35) 0.003
Pairwise comparisons
40–49 vs. 60–69 P = 0.015
Total cholesterol (mmol/liter) 4.5 (3.93–5.83) 5.3 (4.88–5.83) 5.55 (4.5–6.4) 4.95 (4.33–5.5) 4.7 (4.1–5.7) 4.45 (3.58–5.58) 0.038
HDL (mmol/liter) 1.3 (0.95–1.95) 1.2 (1–1.43) 1.3 (1.1–1.5) 1.3 (1.1–1.58) 1.2 (1.1–1.6) 1.1 (0.95–1.15) 0.419
LDL (mmol/liter) 2.35 (1.9–3.55) 3.4 (3–3.9) 3.55 (2.7–4.3) 2.9 (2.33–3.58) 2.8 (2.2–3.5) 2.75 (1.95–3.65) 0.002
Pairwise comparisons
50–59 vs. 70–79 P = 0.008
50–59 vs. 60–69 P = 0.047
Triglycerides (mmol/liter) 1.3 (0.85–4.45) 1.6 (1.08–2.03) 1.7 (1.3–2.2) 1.5 (1.2–2.2) 1.3 (1.05–2.05) 1.55 (1.08–2.08) 0.417
Creatinine (mmol/liter) 68.5 (61.5–75.5) 62 (57–71.5) 71 (64–79) 69 (61–84) 77 (64–95) 72 (64.5–86.5) 0.006
Pairwise comparisons
40–49 vs. 70–79 P = 0.001
Sodium (mmol/liter) 142.5 (139.75–143) 141 (140–142.5) 142 (141–143) 142 (141–144) 142 (140.75–143) 143 (142.5–144) 0.058
  1. for 70 patients, data were provided as below 27.6, for 20 below 28 and for 1 below 31.3
  2. adata available for only 1 patient or no patients
  3. Data are given as Median (25–75%)