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Table 5 Baseline characteristics and outcome in non-lateralized group according to contralateral suppression

From: Clinical outcomes of primary aldosteronism based on lateralization index and contralateral suppression index after adrenal venous sampling in real-world practice: a retrospective cohort study

 

Non-lateralized group (N = 20)

p-value

Contralateral suppression (N = 9)

Non-contralateral suppression (N = 11)

Initial DDD

1.7 (0.5–4.8)

1.6 (0.0–3.7)

0.741

Post DDD

0.8 (0.0–2.3)

1.1 (0.0–4.6)

0.194

Change in DDD %

−34.0 (−100 − + 135)

−16.1 (0.0 − + 230)

0.046

Lateralization index, baseline

2.1 (1.3–2.6)

1.9 (1.0–2.4)

0.823

Lateralization index, post ACTH

2.0 (1.0–2.4)

1.6 (1.0–2.8)

0.431

Contralateral suppression index*

0.5 (0.3–0.9)

2.4 (1.3–5.1)

0.035

PAC (ng/dL)

44.1 (25.4–227.2)

36.5 (21.4–119.2)

0.758

Plasma renin activity (ng/dL)

0.38 (0.10–1.43)

0.16 (0.10–0.39))

0.014

ARR

307.4 (38.4–1192.0)

404.21 (62.1–1263.1)

0.933

Post-therapeutic SBP (mmHg)

125.8 (115–148)

128.2 (107–160)

0.991

Post-therapeutic DBP (mmHg)

82.4 (70–103)

89.8 (60–120)

0.896

Post PAC (ng/dL)

20.0 (5.4–40.5)

19.0 (5.3–48.6)

0.654

Post Plasma renin activity (ng/ml/h)

1.4 (0.27–3.50)

4.51 (0.10–21.25)

0.076

Post ARR

22.1 (1.6.4)

40.7 (4.5–131.8)

0.135

Clinical outcomes

 Complete clinical success

3/9 (33.3)

1/11 (9.1)

0.001

 Partial clinical success

5/9 (55.6)

7/11 (63.6)

0.699

 Absent clinical success

1/9 (11.1)

3/11 (27.2)

0.052

  1. *The contralateral suppression index was defined as uninvolved adrenal A/C ratio compared to A/C ratio of IVC post than 1.0
  2. DDD defined daily dose, LI lateralization index, PAC plasma aldosterone concentration, ARR plasma aldosterone concentration/renin activity, SBP systolic blood pressure, DBP diastolic blood pressure