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Table 2 The hormonal results and functional measurements of the patient with EAS

From: Unusual ectopic ACTH syndrome in a patient with orbital neuroendocrine tumor, resulted false-positive outcome of BIPSS:a case report

A. Hormone tests

Items

Results

  

Normal Ranges

Units

 

2016

2017

  
 

Pre-operation

Post-operation

   

ACTH

138.1

< 1

19.64

50–78

ng/L

PTC-8:00

887.5

51.61

304.7

147.3–609.3

Umol/L

24 h-UFC (1)

3084.5

55.6

110–220

IU/L

(2)

3256.0

  

GH

0.23

0.126–9.88

ng/mL

PRL

25.75

34.77

ND

6.0–29.9

ng/mL

TSH

0.139

0.747

0.507

0.27–4.2

mU/l

FT3

2.82

6.01

4.19

3.6–7.5

pmol/L

FT4

13.35

14.56

15.67

12.0–22.0

pmol/L

Testosterone

0.44

Fillicular phase 2.4–12.6

Luteal phase 1.0–11.4

IU/L

DHEA-S

5.33

Fillicular phase 2.4–12.6

Luteal phase 3.5–12.5

IU/L

LH

6.3

1.6

Fillicular phase 1.7–7.7

Luteal phase

IU/L

FSH

6.3

2.0

Fillicular phase 12.4–233

Luteal phase 22.3–341

IU/L

E2

 

438.9

Fillicular phase 0.2–1.5

Luteal phase 1.7–27

IU/L

P

 

0.1

 

IU/L

B. 1 mg Overnight Dexamethasone Suppression Test

Items

Results

(2016)

Results

(2017)

Units

PTC-8:00 am

985.6

304.7

nmol/L

PTC-(secondary 8:00 am)

959.1

19.77

nmol/L

Suppression Rate

< 50

> 50

%

C. High-dose Dexamethasone Suppression Test

Items

Results

Units

PTC-8:00 am

978.9

nmol/L

PTC-(secondary 8:00 am)

820.3

nmol/L

Suppression Rate

< 50

%

D. Inferior Petrosal Sinus Sampling and Desmopressin Stimulating Test

ACTH

IPS

PV

IPS/PV Ratio

L (ng/L)

R (ng/L)

L

R

0 min

233.2

1120.2

134.5

1.73

8.33

3 min

347.1

> 2000

198.7

1.75

> 10.07

5 min

307.8

1377.0

234.2

1.31

5.88

10 min

262.8

1275.0

236.7

1.11

5.39

PRL

IPS

PV

IPS/PV Ratio

L (ng/L)

R (ng/L)

L

R

0 min

26.35

136.3

23.44

1.12

5.83

3 min

24.25

114.3

24.48

0.99

4.67

5 min

24.62

99.53

24.92

0.99

3.99

10 min

23.95

94.64

22.9

1.05

4.13

  1. ACTH: Adrenocorticotropic Hormone, PTC: Plasma total cortisol, IPS: Inferior Petrosal Sinus, L: left, R: right, PV: peripheral vein, PRL: prolactin, IPS/PV Ratio: The ratio of the ACTH concentration inthe inferior petrosal sinus and that in simultaneously drawn peripheral venous blood
  2. IPS / PV ≥ 2 (≥ 3 post CRH) –Pituitary Cushing Syndrome(Cushing’s disease, CD)
  3. IPS / PV < 2 – Ectopic Cushing’s Synd
  4. R-PS / L-PS ≥ 1,4 – Lateralization