Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis

Zhai, Na; Bidares, Ramtin; Makoui, Masoud Hassanzadeh; Aslani, Saeed; Mohammadi, Payam; Razi, Bahman; Imani, Danyal; Yazdchi, Mohammad; Mikaeili, Haleh

doi:10.1186/s12902-020-00575-8

Table 4 Meta-regression analyses of potential source of heterogeneity

From: Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis

Heterogeneity Factor		Coefficient	SE	T	P-value	95% CI
Heterogeneity Factor						UL	LL
FokI (rs2228570)
Publication Year	Dominant model	0.037	0.021	1.74	0.09	- 0.006	0.082
	Recessive model	0.763	0.313	2.44	0.02	0.117	1.410
	Allelic model	0.037	0.018	2.07	0.04	0.001	0.074
	ff vs. FF	0.631	0.242	2.60	0.01	0.130	1.131
	Ff vs. FF	0.032	0.022	1.43	0.16	−0.014	0.078
Ethnicity	Dominant model	0.322	0.081	3.97	0.001	0.155	0.489
	Recessive model	−1.10	1.43	−0.77	0.44	−4.063	1.85
	Allelic model	0.231	0.073	3.15	0.004	0.080	0.382
	ff VS. FF	−0.591	1.134	−0.52	0.60	−2.932	1.749
	Ff vs. FF	0.217	0.097	2.23	0.03	0.017	0.416
TaqI (rs731236)
Publication Year	Dominant model	0.069	0.037	1.83	0.08	−0.010	0.148
	Recessive model	0.020	0.031	0.65	0.52	−0.046	0.087
	Allelic model	0.038	0.026	1.47	0.15	−0.016	0.093
	tt vs. TT	0.063	0.048	1.32	0.20	−0.039	0.166
	Tt vs.TT	0.064	0.037	1.72	0.10	−0.014	0.142
Ethnicity	Dominant model	−0.249	0.207	−1.20	0.24	−0.684	0.185
	Recessive model	−0.114	0.145	−0.79	0.44	− 0.424	0.194
	Allelic model	−0.145	0.123	−1.18	0.25	−0.404	0.113
	tt vs. TT	−0.167	0.253	−0.66	0.51	−0.707	0.373
	Tt vs.TT	−0.250	0.200	−1.25	0.22	−0.670	0.170
BsmI (rs1544410)
Publication Year	Dominant model	0.142	0.046	3.03	0.005	0.046	0.237
	Recessive model	0.031	0.024	1.29	0.20	−0.018	0.081
	Allelic model	0.063	0.025	2.54	0.01	0.012	0.115
	bb vs. BB	0.103	0.047	2.17	0.03	0.006	0.200
	Bb vs. BB	0.095	0.033	2.84	0.008	0.026	0.163
Ethnicity	Dominant model	0.482	0.265	1.82	0.07	−0.058	1.023
	Recessive model	−0.133	0.139	−0.96	0.34	−0.417	0.149
	Allelic model	0.152	0.143	1.07	0.293	−0.138	0.444
	bb vs. BB	−0.274	0.280	−0.98	0.33	−0.846	0.296
	Bb vs. BB	0.381	0.188	2.03	0.05	−0.002	0.764
ApaI (rs7975232)
Publication Year	Dominant model	0.098	0.054	1.81	0.08	−0.014	0.211
	Recessive model	0.005	0.030	0.18	0.86	−0.057	0.068
	Allelic model	0.052	0.032	1.64	0.11	−0.013	0.119
	aa vs. AA	0.042	0.042	0.98	0.33	−0.047	0.131
	Aa vs. AA	0.027	0.019	1.37	0.18	−0.014	0.069
Ethnicity	Dominant model	−0.130	0.290	−0.45	0.65	−0.733	0.471
	Recessive model	−0.086	0.175	−0.49	0.62	−0.452	0.279
	Allelic model	0.007	0.171	0.04	0.96	−0.348	0.362
	aa vs. AA	−0.279	0.243	−1.15	0.26	−0.785	0.226
	Aa vs. AA	0.033	0.103	0.32	0.74	−0.181	0.248

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