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Table 3 Main results of pooled ORs in meta-analysis of Vitamin D Receptor gene polymorphisms

From: Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis

Group

Genetic Model

Case/Control

Test of Association

Test of Heterogenicity

Test of publication bias

(Begg’s test)

(Egger’s test)

OR

95%CI (P value)

I2 (%)

P

Z

P

T

P

FokI (rs2228570)

Overall

Dominant model

3723 / 5578

0.92

0.79–1.08 (0.31)

< 0.001

< 0.001

0.28

0.78

0.79

0.43

Recessive model

3723 / 5578

0.98

0.71–1.35 (0.91)

< 0.001

< 0.001

1.43

0.15

1.28

0.21

Allelic model

3723 / 5578

0.96

0.81–1.14 (0.65)

< 0.001

< 0.001

0.71

0.47

0.87

0.39

ff vs. FF

3723 / 5578

0.96

0.69–1.35 (0.83)

< 0.001

< 0.001

1.70

0.09

1.78

0.08

Ff vs. FF

3723 / 5578

0.94

0.79–1.12 (0.49)

< 0.001

< 0.001

1.19

0.23

1.23

0.22

European

Dominant model

3723 / 5578

0.86

0.74–1.00 (0.05)

0.268

0.268

−0.15

0.88

0.33

0.74

Recessive model

2077 / 3849

1.00

0.77–1.30 (0.98)

0.011

0.011

0.60

0.54

1.15

0.27

Allelic model

2077 / 3849

0.93

0.82–1.06 (0.28)

0.015

0.015

- 0.05

0.96

0.69

0.50

ff vs. FF

2077 / 3849

0.90

0.67–1.20 (0.46)

0.046

0.046

0.27

0.78

1.01

0.33

Ff vs. FF

2077 / 3849

0.86

0.75–0.99 (0.04)

0.435

0.435

0.74

0.45

0.59

0.56

Asian

Dominant model

2077 / 3849

0.76

0.55–1.05 (0.09)

0.015

0.015

- 0.74

0.45

−0.31

0.76

Recessive model

1107 / 1272

0.93

0.23–3.68 (0.91)

< 0.001

< 0.001

1.65

0.09

3.26

0.02

Allelic model

1107 / 1272

0.78

0.46–1.33 (0.36)

< 0.001

< 0.001

− 0.25

0.80

0.04

0.97

ff vs. FF

1107 / 1272

0.87

0.25–3.01 (0.82)

< 0.001

< 0.001

1.95

0.05

3.01

0.03

Ff vs. FF

1107 / 1272

0.84

0.53–1.34 (0.47)

< 0.001

< 0.001

0.49

0.62

0.50

0.63

African

Dominant model

1107 / 1272

2.06

1.20–3.53 (0.008)

0.225

0.225

- 0.52

0.60

−0.19

0.88

Recessive model

312 /220

2.14

1.03–4.43 (0.04)

0.382

0.382

- 0.52

0.60

−0.60

0.65

Allelic model

312 /220

1.77

1.06–2.97 (0.02)

0.057

0.057

0.52

0.60

0.23

0.85

ff vs. FF

312 /220

3.11

1.44–6.69 (0.004)

0.493

0.493

- 1.57

0.11

−1.65

0.34

Ff vs. FF

312 /220

1.81

1.13–2.91 (0.01)

0.337

0.337

- 0.52

0.60

0.03

0.98

TaqI (rs731236)

Overall

Dominant model

1873 / 1895

1.06

0.78 – 1.45 (0.70)

78.3

< 0.001

− 0.45

0.65

−1.61

0.12

Recessive model

1873 / 1895

0.91

0.66 – 1.26(0.58)

59.1

0.001

−1.93

0.05

−1.93

0.07

Allelic model

1873/ 1895

1.02

0.81 – 1.29 (0.86)

81.9

< 0.001

−0.24

0.80

− 0.96

0.34

tt vs. TT

1873 / 1895

0.90

0.58 – 1.39 (0.62)

72.9

< 0.001

−2.14

0.03

−2.65

0.01

Tt vs.TT

1873 / 18995

1.12

0.84– 1.49 (0.45)

70.7

< 0.001

−0.39

0.69

−1.04

0.31

European

Dominant model

840 / 878

0.82

0.59–1.13 (0.23)

49.1

0.056

−1.48

0.13

−1.88

0.11

Recessive model

840 / 878

0.78

0.50–1.21 (0.26)

55.1

0.029

−1.24

0.21

−0.95

0.38

Allelic model

840 / 878

0.92

0.76–1.11 (0.36)

9.6

0.356

−1.73

0.08

−1.27

0.25

tt vs. TT

840 / 878

0.75

0.44–1.27 (0.28)

61.1

0.012

−1.73

0.08

−1.68

0.14

Tt vs.TT

840 / 878

0.87

0.64–1.20 (0.40)

39.8

0.114

− 0.99

0.32

−1.10

0.31

Asian

Dominant model

1033 / 1017

1.40

0.75 – 2.58 (0.28)

85.7

< 0.001

0

1

−1.08

0.31

Recessive model

1033 / 1017

1.05

0.51 – 2.16 (0.88)

74.5

0.008

−2.44

0.01

−3.55

0.02

Allelic model

1033 / 1017

1.27

0.75 – 2.14 (0.36)

88.7

< 0.001

0

1

−0.75

0.45

tt vs. TT

1033 / 1017

1.03

0.37 – 2.85 (0.95)

85.4

< 0.001

−1.69

0.09

−3.10

0.03

Tt vs.TT

1033 / 1017

1.46

0.83 – 2.58 (0.19)

80.1

< 0.001

− 0.83

0.40

− 0.77

0.46

BsmI (rs1544410)

Overall

Dominant model

4826 / 7159

1.02

0.80– 1.30 (0.88)

76.3

< 0.001

−0.25

0.80

0.48

0.63

Recessive model

4826 / 7159

0.94

0.80 – 1.10 (0.45)

52.9

< 0.001

0.13

0.89

0.20

0.84

Allelic model

4826 / 7159

0.99

0.86 – 1.15 (0.92)

77.6

< 0.001

0.21

0.83

0.16

0.87

bb vs. BB

4826 / 7159

0.96

0.75– 1.23 (0.74)

59.8

< 0.001

−0.59

−0.55

−0.69

0.49

Bb vs. BB

4826 / 7159

1.07

0.88 – 1.29 (0.52)

53.9

< 0.001

−0.19

0.84

−0.58

0.56

European

Dominant model

1938 / 4450

0.94

0.71–1.24 (0.66)

71.0

< 0.001

−0.25

0.80

0.89

0.39

Recessive model

1938 / 4450

1.00

0.85–1.19 (0.95)

20.7

0.223

−0.25

0.80

−0.63

0.54

Allelic model

1938 / 4450

1.00

0.89–1.13 (0.93)

41.7

0.046

−0.35

0.72

−0.75

0.46

bb vs. BB

1938 / 4450

0.99

0.80–1.23 (0.92)

16.1

0.273

0.05

0.96

−0.57

0.57

Bb vs. BB

1938 / 4450

1.05

0.89–1.25 (0.56)

15.0

0.286

−0.45

0.65

−0.99

0.34

Asian

Dominant model

2195 /2004

1.05

0.61 – 1.79 (0.87)

77.8

< 0.001

− 0.12

0.90

−0.38

0.71

Recessive model

2195 /2004

1.02

0.73 – 1.40 (0.92)

65.7

< 0.001

−0.38

0.70

0.18

0.86

Allelic model

2195 /2004

1.00

0.72 – 1.38 (0.97)

85

< 0.001

0.38

0.70

0.24

0.81

bb vs. BB

2195 /2004

1.07

0.55 – 2.09 (0.84)

76.8

< 0.001

−0.12

0.90

−0.42

0.68

Bb vs. BB

2195 /2004

1.07

0.67 – 1.71(0.77)

63.5

< 0.001

0.12

0.90

−0.49

0.63

American

Dominant model

463 / 479

0.57

0.39–0.84 (0.004)

0.0

0.755

1.57

0.11

14.1

0.04

Recessive model

463 / 479

0.62

0.41–0.94 (0.02)

50.5

0.133

0.52

0.60

0.38

0.76

Allelic model

463 / 479

0.66

0.54–0.81 (< 0.001)

0.0

0.549

0.52

0.60

0.80

0.57

bb vs. BB

463 / 479

0.52

0.34–0.80 (0.003)

0.0

0.876

0.52

0.60

0.06

0.96

Bb vs. BB

463 / 479

0.66

0.41–1.05 (0.08)

13.2

0.316

0.52

0.60

1.56

0.36

African

Dominant model

230 / 226

2.41

0.63–9.18 (0.19)

81

0.065

−0.52

0.60

−0.15

0.90

Recessive model

230 / 226

0.99

0.52–1.89 (0.96)

26.8

0.242

−1

0.31

0.18

0.23

Allelic model

230 / 226

1.63

0.65–4.08 (0.29)

86.3

0.031

−0.52

0.60

0.05

0.96

bb vs. BB

230 / 226

1.18

0.26–5.25 (0.83)

67.0

0.082

−1

0.31

0.15

0.35

Bb vs. BB

230 / 226

2.40

0.81–7.17 (0.11)

63.9

0.141

−0.52

0.60

−0.16

0.89

ApaI (rs7975232)

Overall

Dominant model

2436 / 4074

1.03

0.82–1.29 (0.79)

66.2

< 0.001

0.25

0.80

0.62

0.54

Recessive model

2436 / 4074

1.03

0.90–1.17 (0.68)

48.4

0.005

0.24

0.81

0.20

0.84

Allelic model

2436 / 4074

1.05

0.90–1.23 (0.52)

72.7

< 0.001

0.99

0.32

0.98

0.34

aa vs. AA

2436 / 4074

1.02

0.77–1.33 (0.90)

52.9

0.002

−0.18

0.85

−0.56

0.57

Aa vs. AA

2436 / 4074

0.91

0.80–1.04 (0.18)

25.5

0.355

−0.03

0.97

0.05

0.97

European

Dominant model

1258/ 2913

0.91

0.70–1.18 (0.47)

49.1

0.039

−0.98

0.32

−1.24

0.25

Recessive model

1258/ 2913

1.09

0.92–1.30 (0.32)

56.9

0.013

−0.63

0.53

−0.28

0.78

Allelic model

1258/ 2913

0.99

0.81–1.21 (0.90)

68.6

0.001

−1.16

0.24

−0.62

0.54

aa vs. AA

1258/ 2913

1.02

0.72–1.45 (0.91)

53.1

0.024

−1.70

0.08

−1.03

0.33

Aa vs. AA

1258/ 2913

0.90

0.75–1.09 (0.29)

29.5

0.174

−1.70

0.08

−2.23

0.05

Asian

Dominant model

1178 / 1161

1.27

0.78–2.05 (0.34)

77.4

< 0.001

1.70

0.08

0.90

0.39

Recessive model

1178 / 1161

0.91

0.71–1.15 (0.42)

52.0

0.027

1.88

0.06

1.26

0.24

Allelic model

1178 / 1161

1.15

0.82–1.62 (0.40)

82.2

< 0.001

1.34

0.18

1.69

0.13

aa vs. AA

1178 / 1161

1.14

0.63–2.04 (0.66)

64.8

0.002

1.34

0.18

0.23

0.82

Aa vs. AA

1178 / 1161

0.92

0.72–1.18 (0.52)

6.8

0.379

1.46

0.14

1.35

0.22