Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis

Zhai, Na; Bidares, Ramtin; Makoui, Masoud Hassanzadeh; Aslani, Saeed; Mohammadi, Payam; Razi, Bahman; Imani, Danyal; Yazdchi, Mohammad; Mikaeili, Haleh

doi:10.1186/s12902-020-00575-8

Table 2 Distribution of genotype and allele among T1DM patients and controls

From: Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-regression and updated meta-analysis

Study author	T1DM cases					Healthy control					P-HWE	MAF
Study author	FF	Ff	ff	F	f	FF	Ff	Ff	F	f	P-HWE	MAF
FokI (rs2228570)
Ban et al. [33]	50	52	6	152	64	82	138	30	302	198	0.01	0.396
Fassbender et al. [34]	35	30	10	100	50	19	30	8	68	46	0.48	0.403
Gyorffy et al. [35]	32	56	19	120	94	34	47	22	115	91	0.44	0.441
Turpeinen (Turku) et al. [36]	50	150	74	250	298	102	414	292	618	998	0.01	0.617
Turpeinen (Tampere) et al. [36]	7	28	20	42	68	61	226	170	348	566	0.29	0.619
Turpeinen (Oulu) et al. [36]	37	114	98	188	310	93	360	342	546	1044	0.9	0.656
Audi (barcellona) et al. [37]	69	68	18	206	104	105	142	28	352	198	0.04	0.36
Audi (navarra) et al. [37]	35	45	6	115	57	41	53	22	135	97	0.51	0.418
San Pedro et al. [38]	31	35	5	97	45	41	39	8	121	55	0.76	0.312
Zemunik et al. [39]	42	63	29	147	121	73	136	23	282	182	< 0.001	0.392
Capoluongo et al. [40]	89	112	45	290	202	91	127	28	309	183	0.09	0.371
Lemos et al. [41]	81	101	25	263	151	97	114	38	308	190	0.63	0.381
Israni et al. [42]	142	79	15	363	109	116	76	5	308	86	0.06	0.218
Mory et al. [43]	80	81	16	241	113	91	67	24	249	115	0.04	0.315
Panierakis et al. [15]	50	43	7	143	57	64	31	1	159	33	0.18	0.171
Yavuz et al. [44]	61	46	10	168	66	60	63	11	183	85	0.32	0.317
Yokota et al. [45]	50	46	12	146	70	59	20	141	138	302	< 0.001	0.686
Bonakdaran et al. [46]	38	25	6	101	37	18	20	7	56	34	0.71	0.377
Sahin et al. [47]	54	31	0	139	31	43	28	9	114	46	0.19	0.287
Mohammadnejad et al. [48]	49	33	5	131	43	55	40	5	150	50	0.5	0.25
Vedralova et al. [49]	38	60	18	136	96	25	76	12	126	100	< 0.001	0.442
Greer et al. [50]	21	21	8	63	37	28	22	5	78	32	0.82	0.29
Hamed et al. [51]	24	92	16	140	124	8	28	4	44	36	0.008	0.45
Abd-Allah et al. [52]	58	50	12	166	74	78	38	4	194	46	0.8	0.191
Kafoury et al. [53]	23	21	16	67	53	41	12	7	94	26	0.001	0.216
Nasreen et al. [54]	32	12	0	76	12	25	19	0	69	19	0.06	0.215
Mukhtar et al. [55]	84	13	5	181	23	100	0	0	200	0	< 0.001	0
Ali et al. [56]	64	33	3	161	39	79	21	2	179	25	0.66	0.122
Rasoul et al. [57]	178	30	45	386	120	146	67	1	359	69	0.02	0.161
Study author	T1DM cases					Healthy control					P-HWE	MAF
Study author	TT	Tt	tt	T	t	TT	Tt	tt	T	t	P-HWE	MAF
TaqI (rs731236)
Chang et al. [58]	142	15	0	299	15	233	14	1	480	16	0.13	0.032
Fassbender et al. [34]	34	31	10	99	51	19	20	18	58	56	0.02	0.491
Gyorffy et al. [35]	46	34	27	126	88	42	27	34	111	95	< 0.001	0.461
Skrabic et al. [59]	54	55	25	163	105	48	72	12	168	96	0.04	0.363
Bianco et al. [60]	10	18	3	38	24	11	20	5	42	30	0.39	0.416
San Pedro et al. [38]	24	36	11	84	58	31	43	14	105	71	0.88	0.403
Garcia et al. [61]	115	79	22	309	123	121	69	13	311	95	0.46	0.233
Lemos et al. [41]	70	94	41	234	176	91	95	46	277	187	0.02	0.403
Israni et al. [42]	91	112	33	294	178	80	98	19	258	136	0.15	0.345
Panierakis et al. [15]	34	59	7	127	73	10	64	22	84	108	< 0.001	0.562
Yavuz et al. [44]	37	58	22	132	102	41	66	27	148	120	0.96	0.447
Bonakdaran et al. [46]	34	28	7	96	42	20	17	8	57	33	0.21	0.366
Mohammadnejad et al. [48]	32	52	3	116	58	59	41	0	159	41	< 0.001	0.205
Greer et al. [50]	18	26	6	62	38	26	24	5	76	34	0.87	0.309
Abd-Allah et al. [52]	42	66	12	150	90	33	69	18	135	105	0.06	0.437
Cheon et al. [62]	66	15	0	147	15	105	8	0	218	8	0.69	0.035
Khalid et al. [63]	63	22	15	148	52	19	16	15	54	46	0.01	0.46
Iyer et al. [64]	19	14	17	52	48	16	16	18	48	52	0.01	0.52
Rasoul et al. [57]	96	96	61	288	218	156	36	22	348	80	< 0.001	0.186
Ahmed et al. [65]	0	42	8	42	58	0	40	10	40	60	< 0.001	0.6
Study author	T1DM cases					Healthy control					P-HWE	MAF
Study author	BB	Bb	bb	B	b	BB	Bb	bb	B	b	P-HWE	MAF
BsmI (rs1544410)
Hauache et al. [66]	13	39	26	65	91	12	43	39	67	121	0.97	0.643
Chang et al. [58]	4	16	137	24	290	1	16	231	18	478	0.22	0.963
Fassbender et al. [34]	14	35	26	63	87	18	25	14	61	53	0.37	0.464
Gyorffy et al. [35]	19	46	42	84	130	16	53	34	85	121	0.53	0.587
Motohashi et al. [67]	12	64	127	88	318	1	49	172	51	393	0.2	0.885
Skrabic et al. [59]	24	58	52	106	162	17	74	41	108	156	0.06	0.59
Turpeinen (Turku) et al. [36]	97	97	26	291	149	354	388	102	1096	592	0.78	0.35
Turpeinen (Tampere) et al. [36]	29	22	7	80	36	533	488	154	1554	796	0.01	0.338
Turpeinen (Oulu) et al. [36]	90	103	33	283	169	403	305	110	1111	525	< 0.001	0.32
Audi (barcellona) et al. [37]	21	73	59	115	191	46	147	81	239	309	0.13	0.563
Audi (navarra) et al. [37]	20	43	26	83	95	19	53	44	91	141	0.65	0.607
Bianco et al. [60]	13	14	4	40	22	14	17	5	45	27	0.96	0.375
San Pedro et al. [38]	15	40	16	70	72	17	44	27	78	98	0.9	0.556
Capoluongo et al. [40]	62	125	59	249	243	61	122	63	244	248	0.89	0.504
Garcia et al. [61]	21	110	77	152	264	14	74	115	102	304	0.65	0.748
Lemos et al. [41]	43	96	68	182	232	56	107	85	219	277	0.04	0.558
Shimada et al. [68]	32	165	577	229	1319	7	121	471	135	1063	0.8	0.887
Israni et al. [42]	79	120	37	278	194	56	94	47	206	188	0.53	0.477
Mory et al. [43]	60	57	60	177	177	38	74	70	150	214	0.62	0.587
Panierakis et al. [15]	23	57	20	103	97	38	43	15	119	73	0.62	0.38
Yavuz et al. [44]	20	57	40	97	137	14	59	61	87	181	0.96	0.675
Tawfeek et al. [69]	3	18	9	24	36	1	8	5	10	18	0.36	0.642
Bonakdaran et al. [46]	14	26	29	54	84	16	11	18	43	47	< 0.001	0.522
Vedralova et al. [49]	43	47	14	133	75	30	33	20	93	73	0.07	0.439
Mohammadnejad et al. [48]	11	36	40	58	116	9	45	46	63	137	0.66	0.685
Moubarak et al. [70]	7	25	23	39	71	14	26	10	54	46	0.74	0.46
Abd-Allah et al. [52]	27	68	25	122	118	48	52	20	148	92	0.36	0.383
Kafoury et al. [53]	8	13	39	29	91	4	11	41	19	93	0.02	0.83
Cheon et al. [62]	0	13	68	13	149	1	4	108	6	220	< 0.001	0.973
Khalid et al. [63]	51	32	17	134	66	19	21	10	59	41	0.35	0.41
Iyer et al. [64]	8	12	30	28	72	26	12	12	64	36	< 0.001	0.36
Ali et al. [56]	30	45	25	105	95	62	28	12	152	52	0.005	0.254
Rasoul et al. [57]	141	83	29	365	141	120	66	28	306	122	< 0.001	0.285
Ahmed et al. [65]	8	35	7	51	49	32	18	0	82	18	< 0.001	0.19
Study author	T1DM cases					Healthy control					P-HWE	MAF
Study author	AA	Aa	aa	A	a	AA	Aa	aa	A	a	P-HWE	MAF
ApaI (rs7975232)
Chang et al. [58]	16	76	65	108	206	13	105	130	131	365	0.16	0.735
Gyorffy et al. [35]	23	27	57	73	141	33	45	25	111	95	0.21	0.461
Skrabic et al. [59]	66	52	16	184	84	51	66	15	168	96	0.35	0.363
Turpeinen (Turku) et al. [36]	35	106	57	176	220	152	441	204	745	849	0.001	0.532
Turpeinen (Tampere) et al. [36]	13	23	20	49	63	69	229	152	367	533	0.25	0.592
Turpeinen (Oulu) et al. [36]	43	115	81	201	277	165	389	289	719	967	0.09	0.573
Bianco et al. [60]	18	11	2	47	15	11	20	5	42	30	0.39	0.416
San Pedro et al. [38]	15	37	19	67	75	28	43	17	99	77	0.94	0.437
Garcia et al. [61]	54	115	44	223	203	43	125	35	211	195	< 0.001	0.48
Lemos et al. [41]	55	100	50	210	200	68	101	63	237	227	0.04	0.489
Israni et al. [42]	85	133	18	303	169	60	110	27	230	164	0.03	0.416
Panierakis et al. [15]	37	57	6	131	69	23	58	15	104	88	0.03	0.458
Yavuz et al. [44]	36	58	23	130	104	35	70	31	140	132	0.72	0.485
Bonakdaran et al. [46]	13	52	4	78	60	18	26	1	62	28	0.01	0.311
Mohammadnejad et al. [48]	27	48	12	102	72	27	57	16	111	89	0.12	0.445
Greer et al. [50]	15	24	11	54	46	12	32	11	56	54	0.22	0.49
Abd-Allah et al. [52]	44	65	11	153	87	36	68	16	140	100	0.06	0.416
Cheon et al. [62]	5	32	44	42	120	9	34	70	52	174	0.1	0.769
Khalid et al. [63]	49	44	7	142	58	26	21	3	73	27	0.64	0.27
Nasreen et al. [54]	14	25	5	53	35	15	25	4	55	33	0.15	0.375
Iyer et al. [64]	17	16	17	50	50	18	16	16	52	48	0.01	0.48
Mukhtar et al. [55]	43	26	33	112	92	86	0	14	172	28	< 0.001	0.14
Rasoul et al. [57]	192	31	29	415	89	162	37	15	361	67	< 0.001	0.156
Ahmed et al. [65]	24	22	4	70	30	37	13	0	87	13	< 0.001	0.15

P-HWE P value for Hardy–Weinberg equilibrium, MAF minor allele frequency of control group

Back to article page

ISSN: 1472-6823

Contact us

General enquiries: journalsubmissions@springernature.com

BMC Endocrine Disorders

Contact us