Table 1 Characteristics of studies included in meta-analysis of overall T1DM
Study author | Year | Country | Ethnicity | Sex cases/controls | Total cases/control | Age case/control (Mean) | Genotyping method | Quality score |
|---|---|---|---|---|---|---|---|---|
FokI (rs2228570) | ||||||||
Ban et al. [33] | 2001 | Japan | Asian | M = 50/60 F = 100/150 | 108 / 250 | 26.0 ± 3.8 / NR | RFLP-PCR | 7 |
Fassbender et al. [34] | 2002 | Germany | European | M = 42/33 F = 27/30 | 75 / 57 | 34.1 ± 11.1 / 33.5 ± 10.1 | RFLP-PCR | 6 |
Gyorffy et al. [35] | 2002 | Hungary | European | M = 57/50 F = 53/50 | 107 / 103 | 23.5 ± 5.11 / NR | RFLP-PCR | 7 |
Turpeinen (Turku) et al. [36] | 2003 | Finland | European | M = NR F=NR | 274 / 808 | NR / NR | Mini sequencing | 8 |
Turpeinen (Tampere) et al. [36] | 2003 | Finland | European | M = NR F=NR | 55 / 457 | NR / NR | Mini sequencing | 8 |
Turpeinen (Oulu) et al. [36] | 2003 | Finland | European | M = NR F=NR | 249 / 795 | NR / NR | Mini sequencing | 8 |
Audi (barcellona) et al. [37] | 2004 | Spain | European | M = 69/86 F = 153/122 | 155 / 275 | NR / NR | Mini sequencing | 7 |
Audi (navarra) et al. [37] | 2004 | Spain | European | M = 40/46 F = 58/58 | 86 / 116 | NR / NR | Mini sequencing | 7 |
San Pedro et al. [38] | 2005 | Spain | European | M = NR F=NR | 71 / 88 | 14.5 ± 9.9 / NR | RFLP-PCR | 6 |
Zemunik et al. [39] | 2005 | Croatia | European | M = 72/62 F=NR | 134 / 232 | 8.6 ± 4.3 / NR | RFLP-PCR | 7 |
Capoluongo et al. [40] | 2006 | Italy | European | M = 135/111 F = 135/111 | 246 / 246 | 39.3 ± 11.1 / 39.6 ± 9.1 | RFLP-PCR | 8 |
Lemos et al. [41] | 2008 | Portugal | European | M = 113/94 F = 143/106 | 207 / 249 | 27.5 ± 10.2 / 36.8 ± 13.8 | RFLP-PCR | 8 |
Israni et al. [42] | 2009 | India | Asian | M = 131/135 F = 116/81 | 236 / 197 | 15.1 ± 7.30 / 30.1 ± 10.2 | RFLP-PCR | 7 |
Mory et al. [43] | 2009 | Brazil | American | M = NR F=NR | 177 / 182 | 17.2 ± 5.4 / 12.2 ± 8.1 | RFLP-PCR | 7 |
Panierakis et al. [15] | 2009 | Greece | European | M = NR F = 52/44 | 100 / 96 | NR / NR | Mini sequencing | 6 |
Yavuz et al. [44] | 2011 | turkey | European | M = 60/57 F = 73/61 | 117 / 134 | 27.6 ± 7.3 / 26.2 ± 5.3 | RFLP-PCR | 6 |
Yokota et al. [45] | 2012 | Japan | Asian | M = NR F=NR | 108 / 220 | NR / NR | NR | 7 |
Bonakdaran et al. [46] | 2012 | Iran | Asian | M = 28/41 F = 19/26 | 69 / 45 | NR / NR | RFLP-PCR | 6 |
Sahin et al. [47] | 2012 | Turkey | European | M = NR F=NR | 85 / 80 | NR / NR | NR | 6 |
Mohammadnejad et al. [48] | 2012 | Iran | Asian | M = 32/55 F = 50/50 | 87 / 100 | 27.93 ± 10.86 / 28.58 ± 7.40 | RFLP-PCR | 6 |
Vedralova et al. [49] | 2012 | Czech | European | M = NR F=NR | 116 / 113 | 67.0 ± 12.44 / 45.0 ± 7.31 | RFLP-PCR | 6 |
Greer et al. [50] | 2012 | Australia | Australian | M = NR F=NR | 50 / 55 | NR / NR | RFLP-PCR | 6 |
Hamed et al. [51] | 2013 | Egypt | African | M = 64/68 F = 18/22 | 132 / 40 | 8.5 ± 3.3 / 9.0 ± 1.5 | RFLP-PCR | 6 |
Abd-Allah et al. [52] | 2014 | Egypt | African | M = 42/78 F = 42/78 | 120 / 120 | 11.7 ± 2.8 / 11.1 ± 2.6 | RFLP-PCR | 7 |
Kafoury et al. [53] | 2014 | Egypt | African | M = 25/35 F=NR | 60 / 60 | 11.2 ± 3.7 / 27.2 ± 6.4 | RFLP-PCR | 6 |
Nasreen et al. [54] | 2016 | Pakistan | Asian | M = 25/19 F = 23/21 | 44 / 44 | 14.81 ± 2.7 / 17.92 ± 2.8 | RFLP-PCR | 6 |
Mukhtar et al. [55] | 2017 | Pakistan | Asian | M = NR F=NR | 102 / 100 | 13/2 / 13/8 | RFLP-PCR | 6 |
Ali et al. [56] | 2018 | Saudi Arabia | Asian | M = 54/46 F = 43/59 | 100 / 102 | 10.33 ± 3.15 / > 35 | RFLP-PCR | 7 |
Rasoul et al. [57] | 2019 | Kuwait | Asian | M = NR F=NR | 253 / 214 | 8.5 ± 5.5 / 8.9 ± 5.2 | RFLP-PCR | 8 |
TaqI (rs731236) | ||||||||
Chang et al. [58] | 2000 | China | Asian | M = 71/86 F = 156/92 | 157 /248 | 23.5 ± 5.11 / 32.4 ± 6.6 | RFLP-PCR | 8 |
Fassbender et al. [34] | 2002 | Germany | European | M = 57/50 F = 53/50 | 75 /57 | 5.8 ± 2.3 / NR | RFLP-PCR | 6 |
Gyorffy et al. [35] | 2002 | Hungary, | European | M = 57/50 F = 53/50 | 107 / 103 | 23.5 ± 5.11 / NR | RFLP-PCR | 7 |
Skrabic et al. [59] | 2003 | Croatia | European | M = 72/62 F = 60/72 | 134 / 132 | 8.69 ± 4.3 / 8.24 ± 4.9 | RFLP-PCR | 7 |
Bianco et al. [60] | 2004 | Italy | European | M = NR F=NR | 31 / 36 | NR / NR | RFLP-PCR | 6 |
San Pedro et al. [38] | 2005 | Spain | European | M = NR F=NR | 71 / 88 | 14.5 ± 9.9 / NR | RFLP-PCR | 6 |
Garcia et al. [61] | 2007 | Chile | American | M = 120/96 F = 106/97 | 216 / 203 | 9.3 ± 4.2 / 10.3 ± 2.5 | RFLP-PCR | 8 |
Lemos et al. [41] | 2008 | Portugal | European | M = NR F=NR | 205 / 232 | 27.5 ± 10.2 / 36.8 ± 13.8 | RFLP-PCR | 8 |
Israni et al. [42] | 2009 | India | Asian | M = 131/135 F = 116/81 | 236 / 197 | 15.1 ± 7.30 / 30.1 ± 10.2 | RFLP-PCR | 7 |
Panierakis et al. [15] | 2009 | Greece | European | M = NR F = 52/44 | 100 / 96 | NR / NR | Mini sequencing | 6 |
Yavuz et al. [44] | 2011 | Turkey | European | M = 60/57 F = 73/61 | 117 / 134 | 27.6 ± 7.3 / 26.2 ± 5.3 | RFLP-PCR | 6 |
Bonakdaran et al. [46] | 2012 | Iran | Asian | M = 28/41 F = 19/26 | 69 / 45 | NR / NR | RFLP-PCR | 6 |
Mohammadnejad et al. [48] | 2012 | Iran | Asian | M = 32/55 F = 50/50 | 87 / 100 | 27.93 ± 10.86 / 28.58 ± 7.40 | RFLP-PCR | 6 |
Greer et al. [50] | 2012 | Australia | Australian | M = NR F=NR | 50 / 55 | NR / NR | RFLP-PCR | 6 |
Abd-Allah et al. [52] | 2014 | Egypt | African | M = 42/78 F = 42/78 | 120 / 120 | 11.7 ± 2.8 / 11.1 ± 2.6 | RFLP-PCR | 7 |
Cheon et al. [62] | 2015 | Korea | Asian | M = 35/46 F = 53/60 | 81 / 113 | 10.28 ± 3.73 / 9.98 ± 3.56 | RFLP-PCR | 6 |
Khalid et al. [63] | 2016 | Saudi Arabia | Asian | M = NR F=NR | 100 / 50 | 11.48 ± 3.39 / 9.50 ± 4.23 | RFLP-PCR | 6 |
Iyer et al. [64] | 2017 | Saudi Arabia | Asian | M = 25/25 F = 25/25 | 50 / 50 | 25.37 ± 4.07 / 23.44 ± 5.38 | RFLP-PCR | 6 |
Rasoul et al. [57] | 2019 | Kuwait | Asian | M = NR F=NR | 253 / 214 | 8.5 ± 5.5 / 8.9 ± 5.2 | RFLP-PCR | 8 |
Ahmed et al. [65] | 2019 | Egypt | African | M = 24/25 F = 26/25 | 50 / 50 | 11.16 ± 3.27 / 10.97 ± 2.77 | RFLP-PCR | 6 |
BsmI (rs1544410) | ||||||||
Hauache et al. [66] | 1998 | Brazil | American | M = NR F = 31/63 | 78 / 94 | 15.5 ± 6.0 / 49 ± 11 | RFLP-PCR | 6 |
Chang et al. [58] | 2000 | China | Asian | M = 71/86 F = 156/92 | 157 / 248 | 23.5 ± 5.11 / 32.4 ± 6.6 | RFLP-PCR | 8 |
Fassbender et al. [34] | 2002 | Germany | European | M = 57/50 F = 53/50 | 75 / 57 | 5.8 ± 2.3 / NR | RFLP-PCR | 6 |
Gyorffy et al. [35] | 2002 | Hungary | European | M = 57/50 F = 53/50 | 107 / 103 | 23.5 ± 5.11 / NR | RFLP-PCR | 7 |
Motohashi et al. [67] | 2002 | Japan | Asian | M = 96/107 F = 101/121 | 203 / 222 | 34.6 ± 16.9 / 44.4 ± 13.7 | RFLP-PCR | 8 |
Skrabic et al. [59] | 2003 | Croatia | European | M = 72/62 F = 60/72 | 134 / 132 | 8.69 ± 4.3 / 8.24 ± 4.9 | RFLP-PCR | 7 |
Turpeinen (Turku) et al. [36] | 2003 | Finland | European | M = NR F=NR | 220 / 844 | NR / NR | Mini sequencing | 8 |
Turpeinen (Tampere) et al. [36] | 2003 | Finland | European | M = NR F=NR | 58 / 1175 | NR / NR | Mini sequencing | 8 |
Turpeinen (Oulu) et al. [36] | 2003 | Finland | European | M = NR F=NR | 226 / 818 | NR / NR | Mini sequencing | 8 |
Audi (barcellona) et al. [37] | 2004 | Spain | European | M = 69/84 F = 153/121 | 153 / 274 | NR / NR | Mini sequencing | 7 |
Audi (navarra) et al. [37] | 2004 | Spain | European | M = 40/49 F = 58/58 | 89 /116 | NR / NR | Mini sequencing | 7 |
Bianco et al. [60] | 2004 | Italy | European | M = NR F=NR | 31 / 36 | NR / NR | RFLP-PCR | 6 |
San Pedro et al. [38] | 2005 | Spain | European | M = NR F=NR | 71 / 88 | 14.5 ± 9.9 / NR | RFLP-PCR | 6 |
Capoluongo et al. [40] | 2006 | Italy | European | M = 135/111 F = 135/111 | 246 / 246 | 39.3 ± 11.1 / 39.6 ± 9.1 | RFLP-PCR | 8 |
Garcia et al. [61] | 2007 | Chile | American | M = NR F = 106/97 | 208 / 203 | 9.3 ± 4.2 / 10.3 ± 2.5 | RFLP-PCR | 8 |
Lemos et al. [41] | 2008 | Portugal | European | M = NR F=NR | 207 / 248 | 27.5 ± 10.2 / 36.8 ± 13.8 | RFLP-PCR | 8 |
Shimada et al. [68] | 2008 | Japan | Asian | M = 357/417 F=NR | 774 / 599 | 29/8 / NR | RFLP-PCR | 8 |
Israni et al. [42] | 2009 | India | Asian | M = 131/135 F = 116/81 | 236 / 197 | 15.1 ± 7.30 / 30.1 ± 10.2 | RFLP-PCR | 7 |
Mory et al. [43] | 2009 | Brazil | American | M = NR F=NR | 177 / 182 | 17.2 ± 5.4 / 12.2 ± 8.1 | RFLP-PCR | 7 |
Panierakis et al. [15] | 2009 | Greece | European | M = NR F = 52/44 | 100 / 96 | NR / NR | Mini sequencing | 6 |
Yavuz et al. [44] | 2011 | Turkey | European | M = 60/57 F = 73/61 | 117 / 134 | 27.6 ± 7.3 / 26.2 ± 5.3 | RFLP-PCR | 6 |
Tawfeek et al. [69] | 2011 | Arabic Saudi | Asian | M = 0/30 F = 0/14 | 30 / 14 | 35.7 ± 5.33 / 33.2 ± 4.06 | RFLP-PCR | 6 |
Bonakdaran et al. [46] | 2012 | Iran | Asian | M = 28/41 F = 19/26 | 69 / 45 | NR / NR | RFLP-PCR | 6 |
Vedralova et al. [49] | 2012 | Czech | European | M = NR F=NR | 104 / 83 | 67.0 ± 12.44 / 45.0 ± 7.31 | RFLP-PCR | 6 |
Mohammadnejad et al. [48] | 2012 | Iran | Asian | M = 32/55 F = 50/50 | 87 / 100 | 27.93 ± 10.86 / 28.58 ± 7.40 | RFLP-PCR | 6 |
Moubarak et al. [70] | 2013 | Syria | Asian | M = 25/30 F = 24/26 | 55 / 50 | 13.75 ± 6.91 / 39.86 ± 11.66 | RFLP-PCR | 6 |
Abd-Allah et al. [52] | 2014 | Egypt | Africian | M = 42/78 F = 42/78 | 120 / 120 | 11.7 ± 2.8 / 11.1 ± 2.6 | RFLP-PCR | 7 |
Kafoury et al. [53] | 2014 | Egypt | Africian | M = 25/35 F=NR | 60 / 56 | 11.2 ± 3.7 / 27.2 ± 6.4 | RFLP-PCR | 6 |
Cheon et al. [62] | 2015 | Korea | Asian | M = 35/46 F = 53/60 | 81 / 113 | 10.28 ± 3.73 / 9.98 ± 3.56 | RFLP-PCR | 6 |
Khalid et al. [63] | 2016 | Saudi Arabia | Asian | M = NR F=NR | 100 / 50 | 11.48 ± 3.39 / 9.50 ± 4.23 | RFLP-PCR | 6 |
Iyer et al. [64] | 2017 | Saudi Arabia | Asian | M = 25/25 F = 25/25 | 50 / 50 | 25.37 ± 4.07 / 23.44 ± 5.38 | RFLP-PCR | 6 |
Ali et al. [56] | 2018 | Saudi Arabia | Asian | M = 54/46 F = 43/59 | 100 / 102 | 10.33 ± 3.15 / > 35 | RFLP-PCR | 7 |
Rasoul et al. [57] | 2019 | Kuwait | Asian | M = NR F=NR | 253 / 214 | 8.5 ± 5.5 / 8.9 ± 5.2 | RFLP-PCR | 8 |
Ahmed et al. [65] | 2019 | Egypt | African | M = 24/25 F = 26/25 | 50 / 50 | 11.16 ± 3.27 / 10.97 ± 2.77 | RFLP-PCR | 6 |
ApaI (rs7975232) | ||||||||
Chang et al. [58] | 2000 | China | Asian | M = 71/86 F = 156/92 | 157 / 248 | 23.5 ± 5.11 / 32.4 ± 6.6 | RFLP-PCR | 8 |
Gyorffy et al. [35] | 2002 | Hungary | European | M = 57/50 F = 53/50 | 107 / 103 | 23.5 ± 5.11 / NR | RFLP-PCR | 7 |
Skrabic et al. [59] | 2003 | Croatia | European | M = 72/62 F = 60/72 | 134 / 132 | 8.69 ± 4.3 / 8.24 ± 4.9 | RFLP-PCR | 7 |
Turpeinen (Turku) et al. [36] | 2003 | Finland | European | M = NR F=NR | 198 / 797 | NR / NR | Mini sequencing | 8 |
Turpeinen (Tampere) et al. [36] | 2003 | Finland | European | M = NR F=NR | 56 / 450 | NR / NR | Mini sequencing | 8 |
Turpeinen (Oulu) et al. [36] | 2003 | Finland | European | M = NR F=NR | 239 / 843 | NR / NR | Mini sequencing | 8 |
Bianco et al. [60] | 2004 | Italy | European | M = NR F=NR | 31 / 36 | NR / NR | RFLP-PCR | 6 |
San Pedro et al. [38] | 2005 | Spain | European | M = NR F=NR | 71 / 88 | 14.5 ± 9.9 / NR | RFLP-PCR | 6 |
Garcia et al. [61] | 2007 | Chile | American | M = NR F = 106/97 | 213 / 203 | 9.3 ± 4.2 / 10.3 ± 2.5 | RFLP-PCR | 8 |
Lemos et al. [41] | 2008 | Portugal | European | M = NR F=NR | 205 / 232 | 27.5 ± 10.2 / 36.8 ± 13.8 | RFLP-PCR | 8 |
Israni et al. [42] | 2009 | India | Asian | M = 131/135 F = 116/81 | 236 / 197 | 15.1 ± 7.30 / 30.1 ± 10.2 | RFLP-PCR | 7 |
Panierakis et al. [15] | 2009 | Greece | European | M = NR F = 52/44 | 100 / 96 | NR / NR | Mini sequencing | 6 |
Yavuz et al. [44] | 2011 | Turkey | European | M = 60/57 F = 73/61 | 117 / 136 | 27.6 ± 7.3 / 26.2 ± 5.3 | RFLP-PCR | 6 |
Bonakdaran et al. [46] | 2012 | Iran | Asian | M = 28/41 F = 19/26 | 69 / 45 | NR / NR | RFLP-PCR | 6 |
Mohammadnejad et al. [48] | 2012 | Iran | Asian | M = 32/55 F = 50/50 | 87 / 100 | 27.93 ± 10.86 / 28.58 ± 7.40 | RFLP-PCR | 6 |
Greer et al. [50] | 2012 | Australia | Australian | M = NR F=NR | 50 / 55 | NR / NR | RFLP-PCR | 6 |
Abd-Allah et al. [52] | 2014 | Egypt | African | M = 42/78 F = 42/78 | 120 / 120 | 11.7 ± 2.8 / 11.1 ± 2.6 | RFLP-PCR | 7 |
Cheon et al. [62] | 2015 | Korea | Asian | M = 35/46 F = 53/60 | 81 / 113 | 10.28 ± 3.73 / 9.98 ± 3.56 | RFLP-PCR | 6 |
Khalid et al. [63] | 2016 | Saudi Arabia | Asian | M = NR F=NR | 100 / 50 | 11.48 ± 3.39 / 9.50 ± 4.23 | RFLP-PCR | 6 |
Nasreen et al. [54] | 2016 | Pakistan | Asian | M = 25/19 F = 23/21 | 44 / 44 | 14.81 ± 2.7 / 17.92 ± 2.8 | RFLP-PCR | 6 |
Iyer et al. [64] | 2017 | Saudi Arabia | Asian | M = 25/25 F = 25/25 | 50 / 50 | 25.37 ± 4.07 / 23.44 ± 5.38 | RFLP-PCR | 6 |
Mukhtar et al. [55] | 2017 | Pakistan | Asian | M = NR F=NR | 102 / 100 | 13/2 / 13/8 | RFLP-PCR | 6 |
Rasoul et al. [57] | 2019 | Kuwait | Asian | M = NR F=NR | 252 / 214 | 8.5 ± 5.5 / 8.9 ± 5.2 | RFLP-PCR | 8 |
Ahmed et al. [65] | 2019 | Egypt | African | M = 24/25 F = 26/25 | 50 / 50 | 11.16 ± 3.27 / 10.97 ± 2.77 | RFLP-PCR | 6 |