Table 3 Comparison of genotypic/ allelic distribution of non-coding SELP variants between vascular risk categories
SELP SNPs | Very high risk category N (%) | High risk category N (%) | Moderate risk category N (%) | Odds ratio (95% CI) | p value | ||||
|---|---|---|---|---|---|---|---|---|---|
Very high risk vs. high risk | High risk vs. moderate risk | Very high risk vs. moderate risk | pa | pb | pc | ||||
rs3917655 genotypes | |||||||||
GG | 30 (55.55) | 56 (51.37) | 46 (53.48) | 1 | 1 | 1 | Â | Â | Â |
GA | 20 (37.03) | 46 (42.20) | 34 (39.53) | 0.81 (0.40 to 1.61) | 1.11 (0.61 to 2.00) | 0.90 (0.44 to 1.85) | 0.550 | 0.720 | 0.771 |
AA | 4 (7.40) | 7 (6.42) | 6 (6.97) | 1.07 (0.29 to 3.93) | 0.96 (0.30 to 3.05) | 1.02 (0.26 to 3.93) | 0.920 | 0.940 | 0.970 |
Alleles | |||||||||
G | 80 (74.07) | 158 (72.47) | 126 (73.25) | 1 | 1 | 1 | Â | Â | Â |
A | 28 (25.93) | 60 (27.53) | 46 (26.75) | 0.92 (0.54 to 1.55) | 1.04 (0.66 to 1.63) | 0.96 (0.55 to 1.65) | 0.750 | 0.860 | 0.870 |
rs3917657 genotypes | |||||||||
CC | 38 (70.37) | 81 (74.31) | 69 (80.23) | 1 | 1 | 1 | Â | Â | Â |
CT | 15 (27.77) | 26 (23.8) | 15 (17.44) | 1.23 (0.58 to 2.58) | 1.47 (0.72 to 3.00) | 1.81 (0.80 to 4.11) | 0.581 | 0.282 | 0.150 |
 CT + TT | 16 (29.62) | 28 (26.16) | 17 (19.76) | 1.22 (0.59 to 2.51) | 1.40 (0.71 to 2.77) | 1.71 (0.78 to 3.76) | 0.593 | 0.331 | 0.183 |
Alleles | |||||||||
C | 91 (84.25) | 188 (86.23) | 153 (88.95) | 1 | 1 | 1 | Â | Â | Â |
T | 17 (15.75) | 30 (13.77) | 19 (11.05) | 1.17 (0.61 to 2.23) | 1.28 (0.69 to 2.37) | 1.50 (0.74 to 3.04) | 0.630 | 0.420 | 0.250 |
rs3917739 genotypes | |||||||||
GG | 6 (11.11) | 11 (10.09) | 14 (16.27) | 1 | 1 | 1 | Â | Â | Â |
GA | 28 (51.85) | 52 (47.70) | 31 (36.04) | 0.99 (0.33 to 2.95) | 2.13 (0.86 to 5.28) | 2.11 (0.71 to 6.23) | 0.980 | 0.101 | 0.171 |
AA | 20 (37.03) | 46 (42.20) | 41 (47.67) | 0.79 (0.26 to 2.45) | 1.43 (0.58 to 3.49) | 1.14 (0.38 to 3.40) | 0.690 | 0.432 | 0.810 |
Alleles | |||||||||
G | 40 (37.03) | 74 (33.94) | 59 (34.30) | 1 | 1 | 1 | Â | Â | Â |
A | 68 (62.97) | 144 (66.06) | 113 (65.7) | 0.87 (0.54 to 1.41) | 1.02 (0.66 to 1.54) | 0.89 (0.54 to 1.46) | 0.581 | 0.940 | 0.643 |
rs3917843 genotypes | |||||||||
GG | 35 (64.81) | 81 (74.31) | 66 (76.74) | 1 | 1 | 1 | Â | Â | Â |
GA | 19 (35.18) | 24 (22.01) | 19 (22.09) | 1.83 (0.89 to 3.76) | 0.97 (0.49 to 1.92) | 1.88 (0.88to 4.01) | 0.099 | 0.934 | 0.100 |
 GA + AA | 19 (35.18) | 28 (26.16) | 20 (23.25) | 1.57 (0.78 to 3.17) | 1.14 (0.59 to 2.20) | 1.79 (0.84 to 3.79) | 0.209 | 0.695 | 0.127 |
Alleles | |||||||||
G | 89 (82.40) | 186 (85.32) | 151 (87.79) | 1 | 1 | 1 | Â | Â | Â |
A | 19 (17.6) | 32 (14.68) | 21 (12.21) | 1.24 (0.66 to 2.31) | 1.23 (0.68 to 2.23) | 1.53 (0.78 to 3.01) | 0.496 | 0.480 | 0.212 |
rs2235302 genotypes | |||||||||
GG | 21 (38.88) | 42 (38.53) | 35 (40.69) | 1 | 1 | 1 | Â | Â | Â |
GA | 31 (57.40) | 55 (50.45) | 42 (48.83) | 1.13 (0.57 to 2.23) | 1.09 (0.59 to 1.99) | 1.23 (0.60 to 2.50) | 0.730 | 0.770 | 0.561 |
AA | 2 (3.70) | 12 (11.00) | 9 (10.46) | 0.33 (0.07 to 1.63) | 1.11 (0.42 to 2.94) | 0.37 (0.07 to 1.88) | 0.171 | 0.832 | 0.230 |
Alleles | |||||||||
G | 73 (67.59) | 139 (63.76) | 112 (65.11) | 1 | 1 | 1 | Â | Â | Â |
A | 35 (32.41) | 79 (36.24) | 60 (34.89) | 0.84 (0.52 to 1.37) | 1.06 (0.69 to 1.61) | 0.89 (0.53 to 1.49) | 0.490 | 0.783 | 0.673 |
rs3917779 genotypes | |||||||||
CC | 53 (98.24) | 107 (98.15) | 79 (91.86) | 1 | 1 | 1 | Â | Â | Â |
 CT | 1 (1.76) | 2 (1.85) | 7 (8.14) | 1.00 (0.08 to 11.38) | 0.21 (0.04 to 1.04) | 4.70 (0.56 to 39.28) | 0.620 | 0.056 | 0.150 |
 CT + TT | 1 (1.76) | 2 (1.85) | 7 (8.14) | 1.00 (0.08 to 11.38) | 0.21 (0.04 to 1.04) | 4.70 (0.56 to 39.28) | 0.620 | 0.056 | 0.150 |
Alleles | |||||||||
C | 107 (99.07) | 216 (99.08) | 165 (95.93) | 1 | 1 | 1 | Â | Â | Â |
T | 1 (0.93) | 2 (0.92) | 7 (4.07) | 2.01 (0.12 to 32.44) | 0.21 (0.04 to 1.06) | 4.54 (0.55 to 37.42) | 0.622 | 0.059 | 0.160 |
rs3917854 genotypes | |||||||||
GG | 8 (28.57) | 23 (52.27) | 19 (42.22) | 1 | 1 | 1 | Â | Â | Â |
GA | 14 (50) | 16 (36.36) | 17 (37.77) | 2.51 (0.86 to 7.39) | 0.77 (0.312 to 1.94) | 1.95 (0.66 to 5.80) | 0.093 | 0.589 | 0.226 |
AA | 6 (21.4) | 5 (11.36) | 9 (20) | 3.45 (0.82 to 14.47) | 0.46 (0.13 to 1.60) | 1.58 (0.42 to 5.94) | 0.090 | 0.222 | 0.495 |
Alleles | |||||||||
G | 30 (53.57) | 62 (70.45) | 55 (61.11) | 1 | 1 | 1 | Â | Â | Â |
A | 26 (46.43) | 26 (29.55) | 35 (38.89) | 2.07 (1.03 to 4.15) | 0.66 (0.35 to 1.23) | 1.36 (0.69 to 2.67) | 0.041a | Â | 0.369 |