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Table 4 Plasma concentrations of inflammatory factors and TMAO in subgroups of non-PCOS and PCOS without HA cases

From: PCOS without hyperandrogenism is associated with higher plasma Trimethylamine N-oxide levels

 ControlPCOS-N
BMI < 24BMI ≥ 24BMI < 24BMI ≥ 24
IFN-α (pg/ml)2.61 (2.01–3.11)3.91 (2.75–4.70)3.04 (2.78–4.15)3.54 (1.88–4.44)
IFN-γ (pg/ml)2.73 (2.27–3.44)5.38 (4.16–6.50)a3.97 (3.21–5.14)5.10 (4.16–6.48)a
TNF-α (pg/ml)2.73 (2.27–3.24)3.44 (2.51–3.67)3.17 (2.32–3.44)3.04 (2.78–4.15)
MCP-1 (pg/ml)118.44 (93.42–231.53)157.41 (122.61–211.24)149.68 (126.77–196.24)167.63 (130.55–223.05)
IL-6 (pg/ml)3.78 (3.66–9.00)3.78 (3.66–6.46)3.78 (3.66–7.22)5.18 (3.66–15.09)
IL-8 (pg/ml)10.40 (9.01–16.01)11.83 (9.03–15.76)9.30 (9.00–12.64)11.27 (9.30–18.57)
IL-10 (pg/ml)6.65 (3.72–7.01)5.48 (3.72–7.87)5.31 (3.72–7.66)4.67 (3.84–8.61)
IL-17A (pg/ml)1.30 (0.94–1.64)1.94 (1.90–2.24)a1.90 (1.03–2.01)2.25 (1.89–2.82)ac
IL-18 (pg/ml)255.89 (175.33–351.69)354.17 (272.48–431.46)209.55 (174.31–272.67)405.12 (299.34–546.30)ac
IL-33 (pg/ml)37.71 (20.57–74.61)36.79 (18.86–45.30)37.99 (24.70–43.98)30.18 (7.36–67.58)
Plasma TMAO (μmol/L)1.65 (0.75–2.09)1.64 (1.15–2.59)2.18 (1.77–3.86)3.01 (1.59–7.17)a
  1. Data are presented as median (interquartile range). aP < 0.05 versus control-normal weight participants, bP < 0.05 versus control-obese weight participants, cP < 0.05 versus PCOS-normal weight participants. IFN-α Interferon alpha, IFN-γ Interferon gamma, TNF-α Tumor necrosis factor alpha, MCP-1 Monocyte chemoattractant protein-1, IL-6 Interleukin 6, IL-8 Interleukin 8, IL-10 Interleukin 10, IL-17A Interleukin 17A, IL-18 Interleukin 18, IL-33 Interleukin 33, TMAO Trimethylamine N-oxide