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Table 3 The relationship between classic and non-classic insulin resistance

From: Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series

SubjectClassic IASNon-classic IAS
Clinical manifestationPostprandial hypoglycemiaFasting hypoglycemia
Diagnosishigh titers of autoantibodies against endogenous insulin, without exposure to exogenous insulinhigh titers of autoantibodies against exogenous insulin exposure
Medical TreatmentGlucocorticoids (30-60 mg per day) and immunosuppressanta small dose of prednisone (15 mg per day) in combination with a suitable dose of insulin
serum insulin levelsserum insulin concentration > 1000 pmolserum insulin concentration > 1000 pmol