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Table 1 The related information about the patient

From: Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series

CharacteristicPatient1Patient2Patient3Patient4
History of DM (years)141143
Current Age79717952
BMI26.57 kg/m226.35 kg/m226.23 kg/m220.78 kg/m2
Original TreatmentMetforminAcarboseNov 30:36–16;
Metformin
Gansulin 50R: 16–12
Insulin (type and dose)Insulin pump
Lispro
Nov30
12–8 units BID
Nov 30
36–16 units BID
Gansulin 50R
16–12 units BID
Other drug usedn.a.AmiodaroneMeloxicam;
Diclofenac;
Benazepril Hydrochloride
Additional diseaseGout;
Renal insufficiency
Hypertension;
Coronary heart disease
Hypertension;
Arthralgia
Hypertension;
Rheumatic arthritis;
Autoantibodies (detected)AIA(+)
TG (+)35.47μg/L
TGA(−)
AIA(+)
ANA(−)
dsDNA(−)
Sm(−)
RF(−)
SSA(−)
SSB(−)
AIA(+)
TGA(+) 5.93 IU/mL↑
ANA(+) 1:40
dsDNA(−)
Sm(−)
RF(−)
SSA(−)
SSB(−)
ANA(+) 1:40
MPO-ANCA(+) 326.4 AU/mLCCP(+) 249.88 RU/mL
RF (+)65.50 IU/ml↑
TG(+) 348.65 μg/L
dsDNA(−)
Sm(−)
SSA(−)
SSB(−)
Endocrine
 IGF-1n.a.199.7 ng/mL↓1209.0 ng/mL↑78.2 ng/ml -
 GHn.a.0.4 ng/ml0.75 ng/ml0.4 ng/ml
 TSH5.36mIU/L4.33miu/L1.29miu/L1.32miu/L
 free T412.5 pmol/L11.41 pmol/L11.57 pmol/L15.21 pmol/L
 ACTH(8 am-4 pm-0 am)32.06–39.16-47.01 pg/mL30.6–20.4-49.2 pg/ml41.6–16.5-9.9 pg/ml29.5–10-16.9 pg/ml
 GC(8 am-4 pm-0 am)411–406-168 nmol/L294.64–267.93-449.96 nmol/l414.65–195.04-71.57 nmol/l493.75–206.77-315.97 nmol/l
Pancreatic magnetic resonancen.a.NormalFocal cystic changen.a.
  1. Abbreviations n.a not available, IGF-1 insulin like growth factor receptor 1 GH growth hormone TSH thyroid stimulating hormone T4 thyroxine, ACTH adrenocorticotropic hormone, GC glucocorticoid, BID twice a day, AIA anti-immunoglobulin antibodies, TG thyroglobulin, TGA anti-thyroid-globulin antibody, ANA anti-nuclear immune body, dsDNA anti-double stranded DNA antibody, Sm anti-Sm antibody, RF Human rheumatoid factor, MPO Human Mouse myeloperoxidase, ANCA anti-neutrophil cytoplasmic antibody, CCP anti-cyclic peptide containing citrulline, SSA Sjögren’s syndrome A, SSB Sjögren’s syndrome B