Table 1 The related information about the patient
From: Insulin autoimmune syndrome induced by exogenous insulin injection: a four-case series
Characteristic | Patient1 | Patient2 | Patient3 | Patient4 |
|---|---|---|---|---|
History of DM (years) | 14 | 11 | 4 | 3 |
Current Age | 79 | 71 | 79 | 52 |
BMI | 26.57 kg/m2 | 26.35 kg/m2 | 26.23 kg/m2 | 20.78 kg/m2 |
Original Treatment | Metformin | Acarbose | Nov 30:36–16; Metformin | Gansulin 50R: 16–12 |
Insulin (type and dose) | Insulin pump Lispro | Nov30 12–8 units BID | Nov 30 36–16 units BID | Gansulin 50R 16–12 units BID |
Other drug used | n.a. | Amiodarone | Meloxicam; Diclofenac; | Benazepril Hydrochloride |
Additional disease | Gout; Renal insufficiency | Hypertension; Coronary heart disease | Hypertension; Arthralgia | Hypertension; Rheumatic arthritis; |
Autoantibodies (detected) | AIA(+) TG (+)35.47μg/L TGA(−) | AIA(+) ANA(−) dsDNA(−) Sm(−) RF(−) SSA(−) SSB(−) | AIA(+) TGA(+) 5.93 IU/mL↑ ANA(+) 1:40 dsDNA(−) Sm(−) RF(−) SSA(−) SSB(−) | ANA(+) 1:40 MPO-ANCA(+) 326.4 AU/mLCCP(+) 249.88 RU/mL RF (+)65.50 IU/ml↑ TG(+) 348.65 μg/L dsDNA(−) Sm(−) SSA(−) SSB(−) |
Endocrine | ||||
 IGF-1 | n.a. | 199.7 ng/mL↓ | 1209.0 ng/mL↑ | 78.2 ng/ml - |
 GH | n.a. | 0.4 ng/ml | 0.75 ng/ml | 0.4 ng/ml |
 TSH | 5.36mIU/L | 4.33miu/L | 1.29miu/L | 1.32miu/L |
 free T4 | 12.5 pmol/L | 11.41 pmol/L | 11.57 pmol/L | 15.21 pmol/L |
 ACTH(8 am-4 pm-0 am) | 32.06–39.16-47.01 pg/mL | 30.6–20.4-49.2 pg/ml | 41.6–16.5-9.9 pg/ml | 29.5–10-16.9 pg/ml |
 GC(8 am-4 pm-0 am) | 411–406-168 nmol/L | 294.64–267.93-449.96 nmol/l | 414.65–195.04-71.57 nmol/l | 493.75–206.77-315.97 nmol/l |
Pancreatic magnetic resonance | n.a. | Normal | Focal cystic change | n.a. |