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Table 4 Total testosterone, fasting insulin, and homeostasis model assessment of insulin resistance according to the groups and the genotypes of vitamin D receptor gene polymorphisms

From: Vitamin D receptor and binding protein polymorphisms in women with polycystic ovary syndrome: a case control study

Variables

Groups

VDR polymorphisms

Genotypes

Adjusted mean

95% CI

P for group

P for genotype

P for interaction

TT

Control

rs10735810

GG

45.88

44.09~47.67

< 0.001

0.024

0.043

AG

46.07

44.51~47.64

AA

45.64

43.07~48.22

PCOS

GG

73.67

71.01~76.32

AG

79.11

76.80~81.42

AA

75.51

71.51~79.51

Fasting insulina

Control

rs10875695

AC

1.41

1.04~1.91

< 0.001

0.087

0.011

CC

1.06

0.74~1.51

AA

3.12

1.77~5.50

PCOS

AC

5.74

4.46~7.39

CC

7.33

5.51~9.76

AA

6.07

3.91~9.41

HOMA-IRa

Control

rs10875695

AC

0.30

0.22~0.41

< 0.001

0.100

0.009

CC

0.22

0.16~0.32

AA

0.66

0.38~1.18

PCOS

AC

1.22

0.95~1.57

CC

1.55

1.17~2.07

AA

1.25

0.81~1.95

  1. Adjusted for age and body mass index
  2. VDR vitamin D receptor, CI confidence interval, TT total testosterone, PCOS polycystic ovary syndrome, HOMA-IR homeostasis model assessment of insulin resistance
  3. aLogarithmic transformations were applied for analyses and adjusted means are geometric means after adjustment for age and body mass index
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BMC Endocrine Disorders

ISSN: 1472-6823

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