From: A patient with extensive cerebral calcification due to pseudohypoparathyroidism: a case report
Our case report | Ye Sel Kim etal | Perera et al | Song CY etal | |
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Clinical presentation | Progressive slowness of speech, unsteady gait, acute onset altered behavior, generalized seizure | Focal Seizures | Behavioral changes | Clinical manifestations of acute parkinsonism |
Radiological Findings | Extensive cerebral cortical,cerebellar, bilateral basalganglia and thalamic calcification | Cortical and sub-cortical calcifications with basalganglia,thalami and cerebellar calcifications. | Normal CT brain | Basal ganglia calcifications |
Important biochemistry | Hypocalcemia,hyperphosphatemia,elevated serum intact PTH, marginally low Vitamin D levels | Hypocalcemia,Hyperphosphatemia elevated serum intact PTH | Hypocalcemia,high normal serumphosphate levels,marked elevation of serum intact PTH levels. | Hypocalcemia and hyperphophatemia |
Diagnosis | Pseudohypoparathyroidism | Pseudohypoparathyroidism | Pseudohypoparathyroidism | Pseudohypoparathyroidism |
Outcome | Responded to calcium and vitamin D supplementation. | Clinical and biochemical response to Calcium and vitamin D Suplimentation | Not available | Marked improvement of dyskinesias with calcium supplimentation |
Other Remarks | First reported case of PHP with cortical calcifications in Sri lanka | Rare presentation of PHP with cortical and subcortical calcifications |