Skip to main content

Table 2 Main clinicopathological characteristics of all relevant studies

From: Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies

First author (Ref.) T2DM without DPN T2DM with DPN
N (M/F) Age (yrs.) LDL (mmol/L) SBP (mmHg) P-value* N (M/F) Age (yrs.) LDL (mmol/L) SBP (mmHg) P-value**
Zhao W. et al. [4] 365 (230/135) 59.48 2.75 ± 0.86 130.29 ± 15.93 0.01 104 (53/51) 66.94 2.62 ± 0.82 135.81 ± 17.65 0.133
Wu F. et al. [5] 560 (338/222) 53.20 2.84 ± 0.96 129.10 ± 17.30 <0.01 574 (307/267) 61.00 2.66 ± 0.95 134.4 ± 18.40 0.002
ALMA R. et al. [6] 12 (6/6) 53.60 2.20 ± 0.70 NA NA 70 (46/24) 60.23 2.30 ± 1.25 NA NA
Yang J. et al. [7] 1287 (626/661) 58.61 2.78 ± 1.01 132.06 ± 20.54 0.03 224 (117/107) 66.58 2.75 ± 0.99 134.72 ± 22.25 0.438
Bilir B. et al. [8] 53 (24/29) 58.85 3.59 ± 1.40 128.97 ± 11.73 NA 46 (23/23) 56.91 3.15 ± 0.99 131.62 ± 14.25 NA
Sharon L. et al. [9] 1767 (866/901) 57.20 2.76 ± 0.83 137.60 ± 18.70 < 0.01 214 (135/79) 60.10 2.71 ± 0.81 146.00 ± 20.60 0.45
Yong J. et al. [10] 90 (50/40) 54.90 2.90 ± 0.88 NA NA 90 (46/44) 54.10 2.73 ± 0.82 NA 0.18
Su J. et al. [11] 461 (248/213) 56.00 2.67 ± 0.82 134.00 ± 17.00 0.10 102 (51/51) 58.40 2.60 ± 0.86 137.00 ± 19.00 0.44
Zhang Y. et al. [12] 642 (342/300) 60.03 2.92 ± 0.96 134.29 ± 19.14 0.00 417 (247/170) 61.66 2.95 ± 1.15 142.50 ± 22.39 0.60
Won J. et al. [13] 2661 (1346/1315) 59.40 2.60 ± 0.09 127.00 ± 14.40 0.39 1338 (593/745) 62.70 2.40 ± 0.90 127.50 ± 15.50 0.02
Lin X. et al. [53] 123 (NA) 52.83 3.19 ± 0.94 135.52 ± 17.84 < 0.05 77 (NA) 60.79 3.39 ± 1.28 143.12 ± 22.72 > 0.05
Qiao X. et al. [54] 128 (53/75) 62.30 2.96 ± 0.77 133.00 ± 16.00 0.03 57 (26/31) 64.50 2.98 ± 1.09 141.00 ± 13.00 0.90
Sadosky A. et al. [34] 288,328 (134,761/153580) 61.40 2.62 ± 0.85 NA NA 35,050 (17,166/17871) 64.80 2.37 ± 0.84 NA 0.00
YM. S. et al. [55] 785 (403/382) 54.60 2.52 ± 0.81 132.00 ± 15.00 0.07 197 (94/103) 57.10 2.5 ± 0.88 135.00 ± 17.00 0.76
Khawaja N. et al. [56] 607 (201/195) 62.70 2.61 ± 0.78 142.40 ± 18.10 <0.01 396 (279/328) 57.80 2.64 ± 0.80 138.30 ± 17.50 <0.01
Zhang Q. et al. [57] 159 (79/80) 59.75 2.68 ± 0.95 133.30 ± 18.14 0.03 95 (48/47) 64.02 2.54 ± 1.16 138.85 ± 21.18 0.29
Jangh M. et al. [58] 202 (NA) 49.40 3.39 ± 1.03 125.00 ± 21.30 <0.05 608 (NA) 53.80 3.37 ± 0.95 129.20 ± 23.40 0.90
Kim S. et al. [59] 761 (360/401) 62.50 2.44 ± 0.84 128.00 ± 16.00 0.41 577 (233/344) 63.60 2.45 ± 0.88 127.00 ± 15.00 0.98
Bansal D. et al. [14] 1420 (701/719) 52.50 2.79 ± 1.03 NA NA 586 (288/298) 57.10 2.379 ± 1.20 NA <0.01
Buraczy M. et al. [15] 838 (400/438) 62.90 2.80 ± 1.09 NA NA 406 (194/212) 63.00 2.80 ± 1.05 NA 1.00
Luo Y. et al. [16] 178 (107/71) 53.00 2.70 ± 0.90 NA NA 234 (126/108) 59.00 2.60 ± 0.90 NA 0.43
Ren Z. et al. [17] 385 (191/194) 66.40 2.50 ± 0.80 133.00 ± 18.00 0.46 402 (204/198) 63.80 2.60 ± 0.80 132.00 ± 18.00 0.15
Andersen S. et al. [44] 1178 (693/485) 60.90 3.42 ± 0.12 148.00 ± 21.00 <0.05 78 (42/36) 60.60 3.10 150.50 ± 14.23 <0.05
Anastasi T. et al. [45] 274 (143/131) 63.30 3.34 ± 1.40 141.20 ± 19.70 <0.01 107 (77/30) 66.10 3.00 ± 1.10 150.40 ± 22.90 0.02
Xu T. et al. [46] 397 (111/286) 62.34 3.07 ± 0.90 137.14 ± 19.72 0.27 160 (50/90) 62.38 3.13 ± 1.07 135.04 ± 21.36 0.50
Zhu T. et al. [52] 32 (16/16) 54.38 2.64 ± 0.76 126.96 ± 11.30 NA 32 (15/17) 56.00 2.94 ± 1.23 128.97 ± 11.97 NA
Deng W. et al. [51] 80 (43/37) 60.68 2.71 ± 0.63 127.86 ± 16.36 0.08 122 (72/49) 60.69 2.76 ± 0.70 132.64 ± 20.26 0.92
Thainá R. et al. [50] 258 (101/157) 66.00 2.94 ± 1.01 142.00 ± 22.00 0.07 168 (61/107) 70.00 3.04 ± 0.99 146.00 ± 23.00 0.36
Miric D. et al. [35] 51 (20/31) 61.50 3.88 ± 1.32 NA NA 29 (13/16) 62.90 4.01 ± 1.45 NA NA
Hussain G. et al. [42] 22 (10/12) 51.90 2.29 ± 0.34 132.82 ± 10.63 NA 64 (28/36) 54.68 2.50 ± 0.59 140.00 ± 39.14 <0.05
Li L. et al. [43] 2246 (1148/1098) 57.00 3.10 ± 1.19 135.70 ± 18.85 <0.01 1113 (459/654) 62.30 3.09 ± 1.12 139.27 ± 19.15 0.82
Pai Y. et al. [36] 2223 (1280/943) 61.90 2.64 ± 0.81 NA NA 624 (381/243) 71.40 2.51 ± 0.80 NA 0.02
Xu F. et al. [48] 45 (21/24) 58.70 2.70 ± 0.80 139.00 ± 18.00 0.19 45 (25/20) 59.80 2.30 ± 0.60 134.00 ± 18.00 0.01
Wang H. et al. [37] 78 (34/44) 60.59 3.03 ± 0.68 NA NA 129 (54/75) 61.53 2.96 ± 0.88 NA NA
Wang H. et al. [40] 150 (73/77) 60.80 3.60 ± 2.20 135.00 ± 19.70 NA 101 (51/50) 61.80 3.00 ± 1.90 127.00 ± 16.50 NA
Pai Y. et al. [39] 351 (186/165) 72.50 2.54 ± 0.72 133.20 ± 15.00 0.15 275 (147/128) 73.50 2.49 ± 0.73 131.25 ± 14.90 0.93
Mao F. et al. [22] 686 (398/288) 57.73 NA 127.81 ± 13.10 0 264 (157/107) 63.78 NA 131.82 ± 15.33 NA
Hoque S. et al. [33] 304 (NA) 49.68 NA 127.12 ± 12.62 0.20 96 (NA) 51.93 NA 129.33 ± 14.66 NA
  1. *P-values is calculated LDL mean between the T2DM with and without DPN
  2. **P-values is calculated SBP mean between the T2DM with and without DPN
  3. Abbreviations: N, number; M, male; F, femal; T2DM, type-2 diabetes mellitus; DPN, diabetic peripheral neuropathy; LDL, low-density lipoprotein; SBP, systolic blood pressure; mmol/L, millimole per liter; mmHg, millimeter of Mercury; NA, not avalibale