Table 6 Demographic and metabolic characteristics of 502 participants with stable versus unstable OGTT-glucose response curve
Stable | Unstable | P value | |||
|---|---|---|---|---|---|
Monophasic | Multiphasic | Monophasic to Multiphasic | Multiphasic to Monophasic | ||
N | 371 | 9 | 55 | 67 | |
Age (years) | 35.5 ± 12.3 | 37.0 ± 11.3 | 32.9 ± 13.2 | 35.1 ± 14.6 | 0.535 |
Sex (male/female, %) | 62 (16.7)/309 (83.3) | 2 (22.2)/7 (77.8) | 9 (16.4)/46 (83.6) | 9 (13.4)/58 (86.6) | 0.878 |
FBG(mmol/L) | 5.6 ± 0.9 | 5.1 ± 0.6 | 5.2 ± 0.6 | 5.2 ± 0.5 | < 0.001 |
30 min GLU(mmol/L) | 9.2 ± 1.7 | 8.2 ± 1.4 | 8.5 ± 1.3 | 8.3 ± 1.4 | < 0.001 |
2 h GLU(mmol/L) | 8.1 ± 2.7 | 5.6 ± 1.2 | 6.5 ± 1.6 | 6.5 ± 1.7 | < 0.001 |
FINS | 17.7 ± 9.2 | 11.1 ± 5.3 | 15.4 ± 10.0 | 16.8 ± 9.7 | 0.075 |
30 min INS | 111.2 ± 65.3 | 152.8 ± 69.7 | 131.2 ± 74.8 | 150.2 ± 67.7 | < 0.001 |
2 h INS | 128.8 ± 72.2 | 69.3 ± 46.7 | 101.7 ± 66.9 | 97.0 ± 65.7 | < 0.001 |
Glycemic status(n,%) | |||||
NGT | 181 (48.8) | 9 (100) | 42 (76.4) | 51 (76.1) | |
IFG/IGT/IFG + IGT | 145 (39.1) | 0 | 12 (21.8) | 16 (23.9) | < 0.001 |
DM | 45 (12.1) | 0 | 1 (1.8) | 0 | |
Glucose AUC (mg·dL −1· h −1) | 1461.3 ± 366.0 | 1100.2 ± 83.1 | 1230.5 ± 231.0 | 1184.8 ± 208.6 | < 0.001 |
Insulin AUC (mg·dL −1· h − 1) | 19,184.5 ± 8734.1 | 13,817.2 ± 5128.2 | 17,677.0 ± 90,944.7 | 18,637.6 ± 8730.2 | 0.068 |
HOMA-IR | 4.4 ± 2.6 | 2.6 ± 1.2 | 3.6 ± 2.4 | 3.9 ± 2.3 | 0.012 |
Matsuda Index | 2.4 ± 1.6 | 3.8 ± 2.3 | 3.1 ± 2.0 | 3.1 ± 2.0 | < 0.001 |
Insulinogenic index | 29.6 ± 28.3 | 52.8 ± 34.1 | 37.7 ± 23.7 | 55.2 ± 56.7 | < 0.001 |
Disposition index | 17.2 ± 17.3 | 16.3 ± 7.0 | 19.2 ± 18.2 | 24.3 ± 20.4 | 0.025 |