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Table 5 Demographic and metabolic characteristics of 9059 participants with OGTT insulin peak at 30 min, 60 min versus 120 min

From: The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

 

OGTT insulin peak at 30 min

(n = 2935)

OGTT insulin peak at 60 min

(n = 3729)

OGTT insulin peak at 120 min

(n = 2279)

OGTT insulin peak at 180 min

(n = 116)

P

Age (years)

36.1 ± 13.5

37.9 ± 13.1

41.3 ± 13.9

39.7 ± 14.4

<0.001

Sex (male/female), n%

610 (20.8)/2325 (79.2)

1073 (28.8)/2656 (71.2)

611 (26.8)/1668 (73.2)

25 (21.2)/91 (78.8)

<0.001

FBG(mmol/L)

5.2 ± 1.0

5.5 ± 1.0

5.9 ± 1.2

6.3 ± 1.6

<0.001

30 min GLU(mmol/L)

8.6 ± 1.7

9.4 ± 2.0

10.1 ± 2.0

10.2 ± 2.6

<0.001

2 h GLU(mmol/L)

6.9 ± 2.4

7.1 ± 2.6

10.3 ± 3.3

12.9 ± 4.2

<0.001

FINS

13.7 ± 7.9

14.8 ± 8.8

15.5 ± 8.8

17.2 ± 11.2

<0.001

30 min INS

133.0 ± 66.1

95.4 ± 54.9

71.3 ± 43.7

56.4 ± 35.1

<0.001

2 h INS

85.5 ± 59.7

89.6 ± 56.4

147.2 ± 70.6

117.0 ± 62.9

<0.001

Glycemic status(%)

 NGT(%)

2211 (75.3)

2514 (67.4)

424 (18.6)

7 (5.3)

 

 IFG/IGT/IFG + IGT(%)

549 (18.7)

893 (24.0)

1089 (47.8)

38 (32.7)

< 0.001

 DM(%)

175 (6.0)

322 (8.6)

766 (33.6)

71 (61.9)

 

Glucose AUC (mg·dL −1· h −1)

1239.8 ± 329.6

1389.2 ± 362.0

1738.5 ± 440.9

2070.4 ± 580.7

<0.001

Insulin AUC(mg·dL −1· h − 1)

14,403.2 ± 7536.1

16,046.0 ± 8141.5

17,980.4 ± 8741.5

17,006.3 ± 8977.3

<0.001

HOMAIR

3.3 ± 2.1

3.7 ± 2.6

4.2 ± 2.8

5.1 ± 4.5

<0.001

Matsuda Index

3.5 ± 2.2

2.9 ± 1.9

2.6 ± 1.8

2.8 ± 2.6

<0.001

Insulinogenic index

41.8 ± 33.4

23.9 ± 19.4

15.1 ± 13.5

11.7 ± 10.2

<0.001

Disposition index

17.4 ± 17.6

12.7 ± 13.5

9.0 ± 10.7

6.7 ± 7.1

<0.001

  1. Values are reported as the mean ± SD or n (%). FBG fasting blood glucose, 30 min GLU glucose at 30 min, 2 h GLU glucose at 120 min, FINS fasting insulin, 30 min INS insulin at 30 min, 2 h INS insulin at 1200 min, NGT normal glucose tolerance, IFG impaired fasting glucose, IGT impaired glucose tolerance, DM diabetes mellitus, AUC area under the curve