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Table 2 Demographic and metabolic characteristics of 9059 participants with monophasic versus multiphasic OGTT-glucose response curve in different glycemic status

From: The shape of the glucose response curve during an oral glucose tolerance test heralds β–cell function in a large Chinese population

 

NGT(n = 5156)

Prediabetes(n = 2568)

DM(n = 1334)

Monophasic

(n = 4253)

Multiphasic

(n = 903)

P

Monophasic

(n = 2362)

Multiphasic

(n = 206)

P

Monophasic

(n = 1293)

Multiphasic

(n = 41)

P

Age (years)

35.1 ± 12.3

33.9 ± 12.5

0.008

41.3 ± 13.6

40.1 ± 15.4

0.213

45.2 ± 13.7

46.3 ± 13.9

0.598

Sex (male/female), n%

963 (22.6)/3290 (77.4)

159 (17.6)/744 (82.4)

0.001

682 (28.9)/1680 (71.1)

53 (25.7)/153 (74.3)

0.338

455 (35.2)/838 (64.8)

7 (17.1)/34 (82.9)

0.016

FBG (mmol/L)

5.1 ± 0.5

5.1 ± 0.4

< 0.001

5.6 ± 0.6

5.5 ± 0.6

< 0.001

7.0 ± 1.7

6.4 ± 1.2

0.943

30 min (mmol/L)

8.5 ± 1.3

7.9 ± 1.3

< 0.001

9.9 ± 1.5

9.3 ± 1.3

< 0.001

11.9 ± 2.4

12.0 ± 2.2

0.962

2hPG (mmol/L)

6.1 ± 0.9

5.6 ± 1.2

< 0.001

7.8 ± 1.7

8.8 ± 1.2

< 0.001

13.8 ± 3.3

12.6 ± 2.7

0.017

FINS

13.8 ± 8.0

13.0 ± 7.7

0.008

15.6 ± 8.5

15.2 ± 8.4

0.578

17.0 ± 10.4

15.3 ± 8.0

0.301

30 min INS

112.0 ± 61.6

124.1 ± 68.0

< 0.001

91.9 ± 54.4

127.9 ± 63.5

< 0.001

61.7 ± 42.8

87.9 ± 53.6

0.003

2 h INS

88.1 ± 57.0

66.7 ± 50.5

< 0.001

133.8 ± 68.7

115.9 ± 67.8

< 0.001

119.9 ± 73.7

100.6 ± 64.3

0.098

Glucose AUC

(mg·dL −1· h −1)

1197.1 ± 158.0

1094.1 ± 152.8

< 0.001

1563.7 ± 163.9

1398.0 ± 158.4

< 0.001

2219.0 ± 462.6

2010.2 ± 368.5

0.004

Insulin AUC

(mg·dL −1· h − 1)

15,411.0±7733.0

13,198.7±7054.3

< 0.001

18,336.3±8582.0

17,218.6±8506.1

0.073

15,514.8±8888.9

14,599.2±7349.0

0.514

HOMA-IR

3.2 ± 1.9

3.0 ± 1.8

0.002

3.9 ± 2.3

3.7 ± 2.1

0.199

5.4 ± 4.1

4.4 ± 2.8

0.138

Matsuda Index

3.3 ± 1.9

4.1 ± 2.6

< 0.001

2.5 ± 1.6

2.8 ± 1.5

0.004

2.3 ± 1.8

2.6 ± 1.4

0.419

Insulinogenic index

33.1 ± 26.6

46.4 ± 39.6

< 0.001

19.2 ± 13.5

32.9 ± 26.7

< 0.001

9.4 ± 7.8

13.9 ± 10.3

< 0.001

Disposition index

15.1 ± 16.0

17.0 ± 18.2

0.001

11.7 ± 11.7

16.5 ± 17.0

< 0.001

6.9 ± 8.5

7.6 ± 7.1

0.594

  1. Values are reported as the mean ± SD or n (%). NGT normal glucose tolerance, DM diabetes mellitus, FBG fasting blood glucose, 30 min GLU glucose at 30 min, 2 h GLU glucose at 120 min, FINS fasting insulin, 30 min INS insulin at 30 min, 2 h INS insulin at 1200 min, AUC area under the curve
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BMC Endocrine Disorders

ISSN: 1472-6823

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