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Table 6 Relationship between log Adiponectin and Fetal ultrasound markers

From: Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial

Ultrasound Measure

Unadjusted Estimate (95% CI)

Unadjust p value

Adjusted Estimate (95% CI)

Adjust p value

EFW

 

0.010

 

0.008*

 - 28 Weeks

−5.36 (−42.08, 31.35)

0.775

−8.77 (−45.68, 28.14)

0.641

 - 36 Weeks

−94.09 (− 158.68, −29.51)

0.004

−100.85 (−164.98, −36.71)

0.002

SSFM

 

0.110

 

0.101*

 - 28 Weeks

0.11 (−0.05, 0.28)

0.179

0.12 (−0.05, 0.30)

0.160

 - 36 Weeks

−0.12 (− 0.38, 0.13)

0.343

− 0.12 (− 0.38, 0.13)

0.354

AFM

 

0.634

 

0.651*

 - 28 Weeks

−0.05 (− 0.26, 0.16)

0.651

− 0.00 (− 0.21, 0.21)

0.988

 - 36 Weeks

−0.13 (− 0.43, 0.17)

0.393

−0.08 (− 0.39, 0.23)

0.607

MTFM

 

0.688

 

0.517*

 - 28 Weeks

0.00 (−0.23, 0.24)

0.970

−0.01 (− 0.25, 0.23)

0.943

 - 36 Weeks

−0.11 (− 0.69, 0.46)

0.705

−0.20 (− 0.79, 0.39)

0.509

MTLM

 

0.035

 

0.013*

 - 28 Weeks

0.09 (−0.11, 0.29)

0.377

0.09 (−0.12, 0.29)

0.405

 - 36 Weeks

−0.33 (− 0.70, 0.03)

0.074

− 0.41 (− 0.77, − 0.05)

0.027

AC

 

0.012

 

0.010*

 - 28 Weeks

−0.04 (− 0.31, 0.23)

0.768

− 0.04 (− 0.31, 0.23)

0.779

 - 36 Weeks

−0.51 (− 0.82, − 0.21)

0.001

−0.53 (− 0.83, − 0.22)

<.001

BPD

 

0.056

 

0.056*

 - 28 Weeks

0.06 (−0.00, 0.12)

0.055

0.04 (−0.02, 0.11)

0.176

 - 36 Weeks

−0.02 (− 0.08, 0.04)

0.545

− 0.04 (− 0.10, 0.02)

0.244

HC

 

0.042

 

0.043*

 - 28 Weeks

0.09 (−0.13, 0.30)

0.429

0.10 (−0.12, 0.32)

0.363

 - 36 Weeks

−0.20 (− 0.41, 0.02)

0.071

− 0.18 (− 0.39, 0.03)

0.095

FL

 

0.061

 

0.088*

 - 28 Weeks

0.03 (−0.02, 0.08)

0.272

0.02 (−0.03, 0.08)

0.406

 - 36 Weeks

−0.03 (− 0.08, 0.02)

0.179

− 0.04 (− 0.08, 0.01)

0.160

EFW z score

 

0.986

 

0.938*

 - 28 Weeks

−0.24 (− 0.37, − 0.10)

<.001

−0.23 (− 0.37, − 0.10)

<.001

 - 36 Weeks

−0.24 (− 0.38, − 0.09)

0.001

−0.24 (− 0.38, − 0.10)

<.001

AC z score

 

0.427

 

0.371*

 - 28 Weeks

−0.22 (− 0.36, − 0.08)

0.002

−0.21 (− 0.35, − 0.07)

0.004

 - 36 Weeks

−0.30 (− 0.47, − 0.13)

<.001

−0.30 (− 0.46, − 0.13)

<.001

BPD z score

 

0.685

 

0.609*

 - 28 Weeks

0.04 (−0.18, 0.26)

0.749

−0.01 (− 0.23, 0.21)

0.949

 - 36 Weeks

−0.02 (− 0.19, 0.16)

0.861

−0.07 (− 0.26, 0.11)

0.434

HC z score

 

0.759

 

0.702*

 - 28 Weeks

−0.10 (− 0.27, 0.06)

0.204

− 0.08 (− 0.24, 0.08)

0.316

 - 36 Weeks

−0.13 (− 0.29, 0.02)

0.086

−0.12 (− 0.27, 0.03)

0.124

FL z score

 

0.530

 

0.645*

 - 28 Weeks

−0.06 (− 0.23, 0.11)

0.514

− 0.07 (− 0.24, 0.11)

0.454

 - 36 Weeks

−0.12 (− 0.29, 0.04)

0.150

−0.11 (− 0.28, 0.05)

0.176

  1. Results are expressed as the expected difference (ratio) and 95% confidence intervals
  2. Adjusted analyses including BMI category (< 30 vs ≥30), study centre, parity (0 vs ≥1), age at consent, smoking status and SEIFA IRSD quintile
  3. * p value for test of time-by-log Adiponectin interaction to test whether the association between fetal ultrasound measure and log Adiponectin are different at 36 weeks to the association at 28 weeks
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BMC Endocrine Disorders

ISSN: 1472-6823

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